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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2010 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2010 Volume 23 Issue 6

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Article

Differential roles of leptin in regulating cell migration in thyroid cancer cells

  • Authors:
    • Shih-Ping Cheng
    • Pen-Hui Yin
    • Yuan-Ching Chang
    • Chen-Hsen Lee
    • Shih-Yuan Huang
    • Chin-Wen Chi
  • View Affiliations / Copyright

    Affiliations: Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
  • Pages: 1721-1727
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/or_00000817
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Abstract

Excess body weight is associated with a moderately increased risk of thyroid cancer. Adipocyte-derived hormone, leptin, has been shown to enhance cell growth and migration in many cancer types. Limited evidence suggests that leptin has direct actions on the thyroid gland, but there are no data available on the effect of leptin on thyroid cancer cells. We evaluated the action of leptin on gene expression, cell growth, cell cycle, and cell migration in anaplastic (ARO), follicular (WRO) and papillary (CGTH-W3) thyroid carcinoma cell lines. Expression of long-form leptin receptors was observed in all thyroid cancer cell lines. Leptin stimulation did not alter the expression levels of leptin, leptin receptor and sodium-iodide symporter. Cell growth and cell cycle were not changed after leptin treatment. However, leptin was able to promote cell migration of papillary thyroid cancer cells, but inhibited migration of anaplastic and follicular cancer cells. In summary, our study suggests that leptin modulates cell migration of thyroid cancer cells in a cell type-specific manner.

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Copy and paste a formatted citation
Spandidos Publications style
Cheng S, Yin P, Chang Y, Lee C, Huang S and Chi C: Differential roles of leptin in regulating cell migration in thyroid cancer cells . Oncol Rep 23: 1721-1727, 2010.
APA
Cheng, S., Yin, P., Chang, Y., Lee, C., Huang, S., & Chi, C. (2010). Differential roles of leptin in regulating cell migration in thyroid cancer cells . Oncology Reports, 23, 1721-1727. https://doi.org/10.3892/or_00000817
MLA
Cheng, S., Yin, P., Chang, Y., Lee, C., Huang, S., Chi, C."Differential roles of leptin in regulating cell migration in thyroid cancer cells ". Oncology Reports 23.6 (2010): 1721-1727.
Chicago
Cheng, S., Yin, P., Chang, Y., Lee, C., Huang, S., Chi, C."Differential roles of leptin in regulating cell migration in thyroid cancer cells ". Oncology Reports 23, no. 6 (2010): 1721-1727. https://doi.org/10.3892/or_00000817
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng S, Yin P, Chang Y, Lee C, Huang S and Chi C: Differential roles of leptin in regulating cell migration in thyroid cancer cells . Oncol Rep 23: 1721-1727, 2010.
APA
Cheng, S., Yin, P., Chang, Y., Lee, C., Huang, S., & Chi, C. (2010). Differential roles of leptin in regulating cell migration in thyroid cancer cells . Oncology Reports, 23, 1721-1727. https://doi.org/10.3892/or_00000817
MLA
Cheng, S., Yin, P., Chang, Y., Lee, C., Huang, S., Chi, C."Differential roles of leptin in regulating cell migration in thyroid cancer cells ". Oncology Reports 23.6 (2010): 1721-1727.
Chicago
Cheng, S., Yin, P., Chang, Y., Lee, C., Huang, S., Chi, C."Differential roles of leptin in regulating cell migration in thyroid cancer cells ". Oncology Reports 23, no. 6 (2010): 1721-1727. https://doi.org/10.3892/or_00000817
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