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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2010 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2010 Volume 23 Issue 6

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Article

Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines

  • Authors:
    • Hui-Yan Luo
    • Wei Wei
    • Yan-Xia Shi
    • Xiao-Qin Chen
    • Yu-Hong Li
    • Feng Wang
    • Miao-Zhen Qiu
    • Fang-Hua Li
    • Shu-Li Yan
    • Mu-Sheng Zeng
    • Peng Huang
    • Rui-Hua Xu

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Oncology in Southern China and Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, P.R. China
  • Pages: 1735-1745
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/or_00000819
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Abstract

Hypoxia is recognized as an important factor contributing to cancer development and drug resistance. Cetuximab, a chimeric monoclonal antibody to EGFR, is known to inhibit HIF-1α expression levels and to enhance the cytotoxicity of chemotherapeutic agents. We demonstrated that hypoxia induced drug resistance in gastric cancer cells. Cetuximab enhanced oxaliplatin-induced cytotoxicity and apoptosis in normoxia and caused a reversal of drug resistance in hypoxia. Normoxic and hypoxic gastric cancer cells were treated with cetuximab, oxaliplatin or the combination and assessed for cell growth, proliferation, and apoptosis. Combination treatment resulted in a marked inhibition of HIF-1α expression levels in hypoxic cells and caused a significant reduction in the expression of activated phosphorylated AKT, ERK1/2, p-BAD and VEGF in both normoxia and hypoxia with greater levels of inhibition in hypoxia. In summary, cetuximab inhibits HIF-1α expression via the MAPK/ERK and PI3K/AKT signaling pathways and functions to overcome drug resistance induced by hypoxia. Cetuximab-oxaliplatin combination therapy may therefore emerge as an attractive treatment strategy for advanced gastric cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Luo H, Wei W, Shi Y, Chen X, Li Y, Wang F, Qiu M, Li F, Yan S, Zeng M, Zeng M, et al: Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines . Oncol Rep 23: 1735-1745, 2010.
APA
Luo, H., Wei, W., Shi, Y., Chen, X., Li, Y., Wang, F. ... Xu, R. (2010). Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines . Oncology Reports, 23, 1735-1745. https://doi.org/10.3892/or_00000819
MLA
Luo, H., Wei, W., Shi, Y., Chen, X., Li, Y., Wang, F., Qiu, M., Li, F., Yan, S., Zeng, M., Huang, P., Xu, R."Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines ". Oncology Reports 23.6 (2010): 1735-1745.
Chicago
Luo, H., Wei, W., Shi, Y., Chen, X., Li, Y., Wang, F., Qiu, M., Li, F., Yan, S., Zeng, M., Huang, P., Xu, R."Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines ". Oncology Reports 23, no. 6 (2010): 1735-1745. https://doi.org/10.3892/or_00000819
Copy and paste a formatted citation
x
Spandidos Publications style
Luo H, Wei W, Shi Y, Chen X, Li Y, Wang F, Qiu M, Li F, Yan S, Zeng M, Zeng M, et al: Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines . Oncol Rep 23: 1735-1745, 2010.
APA
Luo, H., Wei, W., Shi, Y., Chen, X., Li, Y., Wang, F. ... Xu, R. (2010). Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines . Oncology Reports, 23, 1735-1745. https://doi.org/10.3892/or_00000819
MLA
Luo, H., Wei, W., Shi, Y., Chen, X., Li, Y., Wang, F., Qiu, M., Li, F., Yan, S., Zeng, M., Huang, P., Xu, R."Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines ". Oncology Reports 23.6 (2010): 1735-1745.
Chicago
Luo, H., Wei, W., Shi, Y., Chen, X., Li, Y., Wang, F., Qiu, M., Li, F., Yan, S., Zeng, M., Huang, P., Xu, R."Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines ". Oncology Reports 23, no. 6 (2010): 1735-1745. https://doi.org/10.3892/or_00000819
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