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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2010 Volume 24 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article Open Access

Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients

  • Authors:
    • Angelina Di Carlo
    • Angela Mariano
    • Daniela Terracciano
    • Matteo Ferro
    • Vittorino Montanaro
    • Mariano Marsicano
    • Giuseppe Di Lorenzo
    • Vincenzo Altieri
    • Vincenzo Macchia

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Medicina Sperimentale, Università di Roma ‘La Sapienza’, I-00161 Roma, Italy
  • Pages: 3-8
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/or_00000821
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Abstract

The matrix metalloproteinase family of enzymes is comprised of critically important extracellular proteases whose activity has been implicated in a number of key normal and pathological processes. The latter include growth, progression and metastasis as well as dysregulated angiogenesis that is associated with these events. The MMPs are secreted by all types of cells, and they also carve through the extracellular matrix, allowing cancer cells to take root and metastasize. Endogenous inhibitors typically hold MMPs in check but in cancer, the balance shifts against the inhibitors and in favor of MMPs, which ultimately spill over from blood into urine. By gelatin zymography we verified MMP activity in concentrated urine of patients with prostate disease. Of these patients, 30 had cancer, consisting of 13 with Gleason score 6, 12 with Gleason 7, 2 with Gleason 8, 3 with Gleason 9 and 8 had benign prostate hyperplasia. Zymography showed 4 dominant gelatinolityc bands of 240, 130, 92 and 72 kDa in prostate disease. The most abundant lytic activity is at 92 kDa (MMP-9), whereas MMP-2 is present in lesser quantities. Moreover, MMP-9 activity is enhanced in the urine from patients with benign prostate hyperplasia compared with cancer patients. No correlation between gelatinolytic activity and Gleason score or pathological findings was found.

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Copy and paste a formatted citation
Spandidos Publications style
Di Carlo A, Mariano A, Terracciano D, Ferro M, Montanaro V, Marsicano M, Di Lorenzo G, Altieri V and Macchia V: Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients. Oncol Rep 24: 3-8, 2010.
APA
Di Carlo, A., Mariano, A., Terracciano, D., Ferro, M., Montanaro, V., Marsicano, M. ... Macchia, V. (2010). Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients. Oncology Reports, 24, 3-8. https://doi.org/10.3892/or_00000821
MLA
Di Carlo, A., Mariano, A., Terracciano, D., Ferro, M., Montanaro, V., Marsicano, M., Di Lorenzo, G., Altieri, V., Macchia, V."Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients". Oncology Reports 24.1 (2010): 3-8.
Chicago
Di Carlo, A., Mariano, A., Terracciano, D., Ferro, M., Montanaro, V., Marsicano, M., Di Lorenzo, G., Altieri, V., Macchia, V."Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients". Oncology Reports 24, no. 1 (2010): 3-8. https://doi.org/10.3892/or_00000821
Copy and paste a formatted citation
x
Spandidos Publications style
Di Carlo A, Mariano A, Terracciano D, Ferro M, Montanaro V, Marsicano M, Di Lorenzo G, Altieri V and Macchia V: Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients. Oncol Rep 24: 3-8, 2010.
APA
Di Carlo, A., Mariano, A., Terracciano, D., Ferro, M., Montanaro, V., Marsicano, M. ... Macchia, V. (2010). Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients. Oncology Reports, 24, 3-8. https://doi.org/10.3892/or_00000821
MLA
Di Carlo, A., Mariano, A., Terracciano, D., Ferro, M., Montanaro, V., Marsicano, M., Di Lorenzo, G., Altieri, V., Macchia, V."Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients". Oncology Reports 24.1 (2010): 3-8.
Chicago
Di Carlo, A., Mariano, A., Terracciano, D., Ferro, M., Montanaro, V., Marsicano, M., Di Lorenzo, G., Altieri, V., Macchia, V."Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients". Oncology Reports 24, no. 1 (2010): 3-8. https://doi.org/10.3892/or_00000821
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