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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2010 Volume 24 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2010 Volume 24 Issue 1

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Article

AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion

  • Authors:
    • Junxia Zhang
    • Lei Han
    • Anling Zhang
    • Yingyi Wang
    • Xiao Yue
    • Yongping You
    • Peiyu Pu
    • Chunsheng Kang

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Tianjin Medical University General Hospital and Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, P.R. China
  • Pages: 65-72
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/or_00000829
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Abstract

Recent data suggest that AKT2, one of AKT isoforms, plays an important role in tumorigenesis of human cancers. However, little evidence exists to show the mechanism of AKT2 involved in tumorigenesis. In this study, we show that AKT2 protein expression increased significantly in high grade gliomas in comparison to low grade gliomas and correlated with the expression of NFκB, BCL2, MMP2 and MMP9 by immunostaining. Further, down-regulation of AKT2 expression by antisense AKT2 induced glioma cell apoptosis mediated by NFκB and BCL2. In addition, decreased MMP2 and MMP9 expression in AKT2 knocked-down glioma cells was subsequently detected, consistent with the decreased invasion. These findings indicate that AKT2 expression is associated with more advanced and especially aggressive gliomas and critical for cell survival and invasion.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Han L, Zhang A, Wang Y, Yue X, You Y, Pu P and Kang C: AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion . Oncol Rep 24: 65-72, 2010.
APA
Zhang, J., Han, L., Zhang, A., Wang, Y., Yue, X., You, Y. ... Kang, C. (2010). AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion . Oncology Reports, 24, 65-72. https://doi.org/10.3892/or_00000829
MLA
Zhang, J., Han, L., Zhang, A., Wang, Y., Yue, X., You, Y., Pu, P., Kang, C."AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion ". Oncology Reports 24.1 (2010): 65-72.
Chicago
Zhang, J., Han, L., Zhang, A., Wang, Y., Yue, X., You, Y., Pu, P., Kang, C."AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion ". Oncology Reports 24, no. 1 (2010): 65-72. https://doi.org/10.3892/or_00000829
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Han L, Zhang A, Wang Y, Yue X, You Y, Pu P and Kang C: AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion . Oncol Rep 24: 65-72, 2010.
APA
Zhang, J., Han, L., Zhang, A., Wang, Y., Yue, X., You, Y. ... Kang, C. (2010). AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion . Oncology Reports, 24, 65-72. https://doi.org/10.3892/or_00000829
MLA
Zhang, J., Han, L., Zhang, A., Wang, Y., Yue, X., You, Y., Pu, P., Kang, C."AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion ". Oncology Reports 24.1 (2010): 65-72.
Chicago
Zhang, J., Han, L., Zhang, A., Wang, Y., Yue, X., You, Y., Pu, P., Kang, C."AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion ". Oncology Reports 24, no. 1 (2010): 65-72. https://doi.org/10.3892/or_00000829
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