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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2010 Volume 24 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells

  • Authors:
    • Jong-Hwan Park
    • Yeon-Hee Moon
    • Dong-Jae Kim
    • Soo-A Kim
    • Jee-Bum Lee
    • Sang-Gun Ahn
    • Jung-Hoon Yoon

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, College of Medicine, Konyang University, Daejon 302-718, Korea
  • Pages: 177-181
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/or_00000843
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Abstract

Photodynamic therapy has been developed as an alternative therapy of cancer. The aim of this study was to examine whether PDT with hexenyl ester of 5-aminolaevulinic acid (ALA-hx) inhibits the proliferation of the salivary gland adenocarcinoma SGT cells. Cell proliferation was examined by MTT assay. The gene expression of Coproporphyrinogen oxidase (CPO) and ROS production was also examined. Flow cytometry and in vivo Chorioallantoic membrane (CAM) assay was performed. ALA-hx PDT inhibited effectively the proliferation of SGT cells. Treatment of ALA-hx induced CPO mRNA expression and ROS was produced by ALA-hx PDT in SGT cells. Flow cytometry and LDH assay showed that ALA-hx PDT induced necrotic cell death rather than apoptosis in SGT cells. In vivo CAM assay showed that ALA-hx PDT induced tumor destruction by inducing necrosis. These results indicate that ALA-hx PDT effectively inhibits the proliferation of SGT cells by inducing necrosis.

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Copy and paste a formatted citation
Spandidos Publications style
Park J, Moon Y, Kim D, Kim S, Lee J, Ahn S and Yoon J: Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells. Oncol Rep 24: 177-181, 2010.
APA
Park, J., Moon, Y., Kim, D., Kim, S., Lee, J., Ahn, S., & Yoon, J. (2010). Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells. Oncology Reports, 24, 177-181. https://doi.org/10.3892/or_00000843
MLA
Park, J., Moon, Y., Kim, D., Kim, S., Lee, J., Ahn, S., Yoon, J."Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells". Oncology Reports 24.1 (2010): 177-181.
Chicago
Park, J., Moon, Y., Kim, D., Kim, S., Lee, J., Ahn, S., Yoon, J."Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells". Oncology Reports 24, no. 1 (2010): 177-181. https://doi.org/10.3892/or_00000843
Copy and paste a formatted citation
x
Spandidos Publications style
Park J, Moon Y, Kim D, Kim S, Lee J, Ahn S and Yoon J: Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells. Oncol Rep 24: 177-181, 2010.
APA
Park, J., Moon, Y., Kim, D., Kim, S., Lee, J., Ahn, S., & Yoon, J. (2010). Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells. Oncology Reports, 24, 177-181. https://doi.org/10.3892/or_00000843
MLA
Park, J., Moon, Y., Kim, D., Kim, S., Lee, J., Ahn, S., Yoon, J."Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells". Oncology Reports 24.1 (2010): 177-181.
Chicago
Park, J., Moon, Y., Kim, D., Kim, S., Lee, J., Ahn, S., Yoon, J."Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells". Oncology Reports 24, no. 1 (2010): 177-181. https://doi.org/10.3892/or_00000843
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