Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3

  • Authors:
    • Xuan Zhou
    • Junxia Zhang
    • Qiang Jia
    • Yu Ren
    • Yingyi Wang
    • Lei Shi
    • Ning Liu
    • Guangxiu Wang
    • Peiyu Pu
    • Yongping You
    • Chunsheng Kang
  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/or_00000846
  • Pages: 195-201
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Abstract

Extensive data indicate that miR-21 plays a critical role in gliomagenesis, however, knowledge is limited on the mechanism of action of miR-21, including cell proliferation, apoptosis, and migration. In this study, we showed that down-regulation of miR-21 expression by antisense oligonucleotides inhibited glioma cell proliferation and induced cell apoptosis. Moreover, reduction of miR-21 activated caspase 9 and 3, which may be mediated by modulating multiple potential target genes, such as TIMP3. Together, these findings indicate that miR-21 plays a key role in regulating cell apoptosis in gliomas and may serve as a target for effective therapies.

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July 2010
Volume 24 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhou X, Zhang J, Jia Q, Ren Y, Wang Y, Shi L, Liu N, Wang G, Pu P, You Y, You Y, et al: Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. Oncol Rep 24: 195-201, 2010.
APA
Zhou, X., Zhang, J., Jia, Q., Ren, Y., Wang, Y., Shi, L. ... Kang, C. (2010). Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. Oncology Reports, 24, 195-201. https://doi.org/10.3892/or_00000846
MLA
Zhou, X., Zhang, J., Jia, Q., Ren, Y., Wang, Y., Shi, L., Liu, N., Wang, G., Pu, P., You, Y., Kang, C."Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3". Oncology Reports 24.1 (2010): 195-201.
Chicago
Zhou, X., Zhang, J., Jia, Q., Ren, Y., Wang, Y., Shi, L., Liu, N., Wang, G., Pu, P., You, Y., Kang, C."Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3". Oncology Reports 24, no. 1 (2010): 195-201. https://doi.org/10.3892/or_00000846