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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2010 Volume 24 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2010 Volume 24 Issue 1

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Article

Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3

  • Authors:
    • Xuan Zhou
    • Junxia Zhang
    • Qiang Jia
    • Yu Ren
    • Yingyi Wang
    • Lei Shi
    • Ning Liu
    • Guangxiu Wang
    • Peiyu Pu
    • Yongping You
    • Chunsheng Kang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, P.R. China
  • Pages: 195-201
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/or_00000846
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Abstract

Extensive data indicate that miR-21 plays a critical role in gliomagenesis, however, knowledge is limited on the mechanism of action of miR-21, including cell proliferation, apoptosis, and migration. In this study, we showed that down-regulation of miR-21 expression by antisense oligonucleotides inhibited glioma cell proliferation and induced cell apoptosis. Moreover, reduction of miR-21 activated caspase 9 and 3, which may be mediated by modulating multiple potential target genes, such as TIMP3. Together, these findings indicate that miR-21 plays a key role in regulating cell apoptosis in gliomas and may serve as a target for effective therapies.

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Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Zhang J, Jia Q, Ren Y, Wang Y, Shi L, Liu N, Wang G, Pu P, You Y, You Y, et al: Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. Oncol Rep 24: 195-201, 2010.
APA
Zhou, X., Zhang, J., Jia, Q., Ren, Y., Wang, Y., Shi, L. ... Kang, C. (2010). Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. Oncology Reports, 24, 195-201. https://doi.org/10.3892/or_00000846
MLA
Zhou, X., Zhang, J., Jia, Q., Ren, Y., Wang, Y., Shi, L., Liu, N., Wang, G., Pu, P., You, Y., Kang, C."Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3". Oncology Reports 24.1 (2010): 195-201.
Chicago
Zhou, X., Zhang, J., Jia, Q., Ren, Y., Wang, Y., Shi, L., Liu, N., Wang, G., Pu, P., You, Y., Kang, C."Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3". Oncology Reports 24, no. 1 (2010): 195-201. https://doi.org/10.3892/or_00000846
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Zhang J, Jia Q, Ren Y, Wang Y, Shi L, Liu N, Wang G, Pu P, You Y, You Y, et al: Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. Oncol Rep 24: 195-201, 2010.
APA
Zhou, X., Zhang, J., Jia, Q., Ren, Y., Wang, Y., Shi, L. ... Kang, C. (2010). Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. Oncology Reports, 24, 195-201. https://doi.org/10.3892/or_00000846
MLA
Zhou, X., Zhang, J., Jia, Q., Ren, Y., Wang, Y., Shi, L., Liu, N., Wang, G., Pu, P., You, Y., Kang, C."Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3". Oncology Reports 24.1 (2010): 195-201.
Chicago
Zhou, X., Zhang, J., Jia, Q., Ren, Y., Wang, Y., Shi, L., Liu, N., Wang, G., Pu, P., You, Y., Kang, C."Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3". Oncology Reports 24, no. 1 (2010): 195-201. https://doi.org/10.3892/or_00000846
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