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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2010 Volume 24 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk

  • Authors:
    • Weimin Gao
    • Marjorie Romkes
    • Shilong Zhong
    • Tomoko Nukui
    • Raj A. Persad
    • Patrick J.B. Smith
    • Robert Branch
    • Phouthone Keohavong

  • View Affiliations / Copyright

    Affiliations: The Institute of Environmental and Human Health (TIEHH) and Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409, USA
  • Pages: 257-262
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/or_00000854
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Abstract

Previous studies have suggested that certain genetic polymorphisms, specifically the Xeroderma pigmentosum group D (XPD) gene codon 751 and the X-ray repair cross-complementing group 1 (XRCC1) gene codon 399 polymorphisms, were associated with an increased risk of lung cancer, and, in some studies, with a greater risk for mutations in the p53 tumor suppressor gene in lung tumors. To evaluate whether these gene polymorphisms may be associated with an increased risk for bladder cancer or in association with p53 mutation status in bladder tumors, we screened for polymorphisms at XPD codons 751 and XRCC1 codon 399 in DNA isolated from blood of 194 bladder cancer patients and 313 healthy controls and for mutations in exons 4 to 8 of the p53 gene in bladder tumor DNA from 174 bladder cancer patients. There was a significantly higher prevalence of the XPD 751 Gln allele among the bladder cancer group, compared with the control group. No association was found between bladder cancer risk and the XRCC1 399 polymorphism. p53 mutations were found in 20.1% (35/174) patients. There was no difference in p53 mutation status among individuals with different genotypes. These results suggest that individuals who have the XPD 751 Gln allele may be at an increased risk for bladder cancer, although this may not lead to an increased risk for mutations in the p53 gene.

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Copy and paste a formatted citation
Spandidos Publications style
Gao W, Romkes M, Zhong S, Nukui T, Persad RA, Smith PJ, Branch R and Keohavong P: Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk. Oncol Rep 24: 257-262, 2010.
APA
Gao, W., Romkes, M., Zhong, S., Nukui, T., Persad, R.A., Smith, P.J. ... Keohavong, P. (2010). Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk. Oncology Reports, 24, 257-262. https://doi.org/10.3892/or_00000854
MLA
Gao, W., Romkes, M., Zhong, S., Nukui, T., Persad, R. A., Smith, P. J., Branch, R., Keohavong, P."Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk". Oncology Reports 24.1 (2010): 257-262.
Chicago
Gao, W., Romkes, M., Zhong, S., Nukui, T., Persad, R. A., Smith, P. J., Branch, R., Keohavong, P."Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk". Oncology Reports 24, no. 1 (2010): 257-262. https://doi.org/10.3892/or_00000854
Copy and paste a formatted citation
x
Spandidos Publications style
Gao W, Romkes M, Zhong S, Nukui T, Persad RA, Smith PJ, Branch R and Keohavong P: Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk. Oncol Rep 24: 257-262, 2010.
APA
Gao, W., Romkes, M., Zhong, S., Nukui, T., Persad, R.A., Smith, P.J. ... Keohavong, P. (2010). Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk. Oncology Reports, 24, 257-262. https://doi.org/10.3892/or_00000854
MLA
Gao, W., Romkes, M., Zhong, S., Nukui, T., Persad, R. A., Smith, P. J., Branch, R., Keohavong, P."Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk". Oncology Reports 24.1 (2010): 257-262.
Chicago
Gao, W., Romkes, M., Zhong, S., Nukui, T., Persad, R. A., Smith, P. J., Branch, R., Keohavong, P."Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk". Oncology Reports 24, no. 1 (2010): 257-262. https://doi.org/10.3892/or_00000854
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