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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2010 Volume 24 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C

  • Authors:
    • Dong-Oh Moon
    • Mun-Ock Kim
    • Taek-Jeong Nam
    • Se-Kwon Kim
    • Yung Hyun Choi
    • Gi-Young Kim
  • View Affiliations / Copyright

    Affiliations: Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea
  • Pages: 271-276
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/or_00000856
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Abstract

Although pectenotoxin-2 (PTX-2) is known to regulate the actin depolymerization and to induce apoptosis through downregulation of telomerase activity, little is known on its effect on the cell cycle regulation. Therefore, we investigated the effects of PTX-2 on G2/M arrest in human breast cancer cells (MDA-MB-231 and MCF-7). Treatment with PTX-2 significantly suppressed cell proliferation and induced G2/M phase arrest through down-regulation of cyclin B1 and cdc2 expression, but also through phosphorylation of cdc25C. We found increased phosphorylation of ATM and Chk1/2 in a PTX-2 dose-dependent manner. Furthermore, treatment with PTX-2 increased H2O2 generation with correlated G2/M arrest. Our results showed that ATM- and Chk1/2-mediated phosphorylation of cdc25C plays a major role in G2/M arrest, but not in H2O2 generation induced by PTX-2 treatment. We also observed that PTX-2-induced cell cycle arrest was not restricted to p53 status in human breast cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Moon D, Kim M, Nam T, Kim S, Choi YH and Kim G: Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C . Oncol Rep 24: 271-276, 2010.
APA
Moon, D., Kim, M., Nam, T., Kim, S., Choi, Y.H., & Kim, G. (2010). Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C . Oncology Reports, 24, 271-276. https://doi.org/10.3892/or_00000856
MLA
Moon, D., Kim, M., Nam, T., Kim, S., Choi, Y. H., Kim, G."Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C ". Oncology Reports 24.1 (2010): 271-276.
Chicago
Moon, D., Kim, M., Nam, T., Kim, S., Choi, Y. H., Kim, G."Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C ". Oncology Reports 24, no. 1 (2010): 271-276. https://doi.org/10.3892/or_00000856
Copy and paste a formatted citation
x
Spandidos Publications style
Moon D, Kim M, Nam T, Kim S, Choi YH and Kim G: Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C . Oncol Rep 24: 271-276, 2010.
APA
Moon, D., Kim, M., Nam, T., Kim, S., Choi, Y.H., & Kim, G. (2010). Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C . Oncology Reports, 24, 271-276. https://doi.org/10.3892/or_00000856
MLA
Moon, D., Kim, M., Nam, T., Kim, S., Choi, Y. H., Kim, G."Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C ". Oncology Reports 24.1 (2010): 271-276.
Chicago
Moon, D., Kim, M., Nam, T., Kim, S., Choi, Y. H., Kim, G."Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C ". Oncology Reports 24, no. 1 (2010): 271-276. https://doi.org/10.3892/or_00000856
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