Neutrophil gelatinase-associated lipocalin immunoexpression in renal tumors: Correlation with histotype and histological grade

  • Authors:
    • Valeria Barresi
    • Antonio Ieni
    • Davide Bolignano
    • Carlo Magno
    • Michele Buemi
    • Gaetano Barresi
  • View Affiliations

  • Published online on: August 1, 2010     https://doi.org/10.3892/or_00000860
  • Pages: 305-310
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein with roles in iron trafficking as well as in carcinogenesis and progression of several human neoplasias. Although the renal proximal tubule represents a major source of NGAL synthesis under various injurious stimuli to the kidney, NGAL expression has been rarely evaluated in renal tumors up to now. In view of this, in the present study we analyzed the expression of this protein in renal tumors of different histotype and grade so as to evaluate whether a role for NGAL might be also proposed in the carcinogenesis of these neoplasms. NGAL immunoexpression was analyzed in 30 surgically resected renal tumors [18 clear cell, 5 papillary and 3 chromophobe renal cell carcinomas (RCCs), 2 urothelial carcinomas and 2 oncocytomas] and in the peritoneal metastasis of a clear cell RCC. A variable NGAL immunoexpression was found in 28/30 cases. High NGAL expression was significantly associated with the papillary and chromphobe histotypes (P=0.016) and with a higher histological grade of clear cell and papillary RCC (P=0.004). Moreover, NGAL expression was retained in the peritoneal metastasis of clear cell RCC. Our findings demonstrate that NGAL is expressed in several histotypes of renal tumors. Its highest expression in the papillary and chromophobe histotypes might be related to a higher need in iron uptake, which could be exploited in anti-cancer therapies with iron chelators against these neoplasias. Further studies are required to investigate the potential diagnostic utility of NGAL in the early diagnosis of metastatic progression of RCC.

Related Articles

Journal Cover

August 2010
Volume 24 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Barresi V, Ieni A, Bolignano D, Magno C, Buemi M and Barresi G: Neutrophil gelatinase-associated lipocalin immunoexpression in renal tumors: Correlation with histotype and histological grade . Oncol Rep 24: 305-310, 2010
APA
Barresi, V., Ieni, A., Bolignano, D., Magno, C., Buemi, M., & Barresi, G. (2010). Neutrophil gelatinase-associated lipocalin immunoexpression in renal tumors: Correlation with histotype and histological grade . Oncology Reports, 24, 305-310. https://doi.org/10.3892/or_00000860
MLA
Barresi, V., Ieni, A., Bolignano, D., Magno, C., Buemi, M., Barresi, G."Neutrophil gelatinase-associated lipocalin immunoexpression in renal tumors: Correlation with histotype and histological grade ". Oncology Reports 24.2 (2010): 305-310.
Chicago
Barresi, V., Ieni, A., Bolignano, D., Magno, C., Buemi, M., Barresi, G."Neutrophil gelatinase-associated lipocalin immunoexpression in renal tumors: Correlation with histotype and histological grade ". Oncology Reports 24, no. 2 (2010): 305-310. https://doi.org/10.3892/or_00000860