Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047

  • Authors:
    • Hyo-Soon Jeong
    • Jung-Hyun Kim
    • Hye Yeon Choi
    • Eung-Ryoung Lee
    • Ssang-Goo Cho
  • View Affiliations

  • Published online on: August 1, 2010     https://doi.org/10.3892/or_00000866
  • Pages: 351-356
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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit the enzyme cyclooxygenase (COX), are known to have a potent anti-tumorigenic activity in various cancers. However, the responsible molecular mechanisms of COX inhibition in breast cancer cells remain to be completely elucidated. We examined the effect of the selective COX-1 inhibitor, FR122047 and the selective COX-2 inhibitor, SC791 on cell growth and apoptosis in human breast cancer MCF-7 cells which exhibited a high basal level of COX-1 expression. Compared to SC791, FR122047 treatment led to a distinct suppression of cell growth in MCF-7 cells. Upon FR122047 treatment, there were apparent increases in the ratio of Bax to Bcl-2, mitochondrial cytochrome c release, and apoptosis in MCF-7 cells. Our data showed that treatment of caspase-8 inhibitor could significantly suppress the cleavage of the effector caspase-7 and PARP in FR122047-treated MCF-7 cells which are caspase-3-deficient breast cancer cells, indicating that the induction of apoptosis by FR122047 is significantly dependent on caspase-8 activity in MCF-7 breast cancer cells. Our data suggest that the NSAID FR122047 may have an anti-cancer potential in breast cancer.

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August 2010
Volume 24 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jeong H, Kim J, Choi HY, Lee E and Cho S: Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 . Oncol Rep 24: 351-356, 2010
APA
Jeong, H., Kim, J., Choi, H.Y., Lee, E., & Cho, S. (2010). Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 . Oncology Reports, 24, 351-356. https://doi.org/10.3892/or_00000866
MLA
Jeong, H., Kim, J., Choi, H. Y., Lee, E., Cho, S."Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 ". Oncology Reports 24.2 (2010): 351-356.
Chicago
Jeong, H., Kim, J., Choi, H. Y., Lee, E., Cho, S."Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 ". Oncology Reports 24, no. 2 (2010): 351-356. https://doi.org/10.3892/or_00000866