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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2010 Volume 24 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2010 Volume 24 Issue 2

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Article

Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047

  • Authors:
    • Hyo-Soon Jeong
    • Jung-Hyun Kim
    • Hye Yeon Choi
    • Eung-Ryoung Lee
    • Ssang-Goo Cho

  • View Affiliations / Copyright

    Affiliations: Department of Animal Biotechnology (BK21), Animal Resources Research Center, and RCTCP, Konkuk University, Gwangjin-ku, Seoul 143-701, South Korea
  • Pages: 351-356
    |
    Published online on: August 1, 2010
       https://doi.org/10.3892/or_00000866
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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit the enzyme cyclooxygenase (COX), are known to have a potent anti-tumorigenic activity in various cancers. However, the responsible molecular mechanisms of COX inhibition in breast cancer cells remain to be completely elucidated. We examined the effect of the selective COX-1 inhibitor, FR122047 and the selective COX-2 inhibitor, SC791 on cell growth and apoptosis in human breast cancer MCF-7 cells which exhibited a high basal level of COX-1 expression. Compared to SC791, FR122047 treatment led to a distinct suppression of cell growth in MCF-7 cells. Upon FR122047 treatment, there were apparent increases in the ratio of Bax to Bcl-2, mitochondrial cytochrome c release, and apoptosis in MCF-7 cells. Our data showed that treatment of caspase-8 inhibitor could significantly suppress the cleavage of the effector caspase-7 and PARP in FR122047-treated MCF-7 cells which are caspase-3-deficient breast cancer cells, indicating that the induction of apoptosis by FR122047 is significantly dependent on caspase-8 activity in MCF-7 breast cancer cells. Our data suggest that the NSAID FR122047 may have an anti-cancer potential in breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Jeong H, Kim J, Choi HY, Lee E and Cho S: Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 . Oncol Rep 24: 351-356, 2010.
APA
Jeong, H., Kim, J., Choi, H.Y., Lee, E., & Cho, S. (2010). Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 . Oncology Reports, 24, 351-356. https://doi.org/10.3892/or_00000866
MLA
Jeong, H., Kim, J., Choi, H. Y., Lee, E., Cho, S."Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 ". Oncology Reports 24.2 (2010): 351-356.
Chicago
Jeong, H., Kim, J., Choi, H. Y., Lee, E., Cho, S."Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 ". Oncology Reports 24, no. 2 (2010): 351-356. https://doi.org/10.3892/or_00000866
Copy and paste a formatted citation
x
Spandidos Publications style
Jeong H, Kim J, Choi HY, Lee E and Cho S: Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 . Oncol Rep 24: 351-356, 2010.
APA
Jeong, H., Kim, J., Choi, H.Y., Lee, E., & Cho, S. (2010). Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 . Oncology Reports, 24, 351-356. https://doi.org/10.3892/or_00000866
MLA
Jeong, H., Kim, J., Choi, H. Y., Lee, E., Cho, S."Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 ". Oncology Reports 24.2 (2010): 351-356.
Chicago
Jeong, H., Kim, J., Choi, H. Y., Lee, E., Cho, S."Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047 ". Oncology Reports 24, no. 2 (2010): 351-356. https://doi.org/10.3892/or_00000866
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