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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2010 Volume 24 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article Open Access

Comparative expressed sequence hybridization detects recurrent patterns of altered sequence expression in oral squamous cell carcinoma

  • Authors:
    • Snjezana Janjetovic
    • Carsten Sticht
    • Karl Knoepfle
    • Stefan Joos
    • Christof Hofele
    • Peter Lichter
    • Kolja Freier

  • View Affiliations / Copyright

    Affiliations: Abteilung Molekulare Genetik (B060), Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany
  • Pages: 369-374
    |
    Published online on: August 1, 2010
       https://doi.org/10.3892/or_00000869
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Abstract

Despite its common histology and presentation, oral squamous cell carcinoma (OSCC) is associated with widely varying clinical behaviour and response to therapy. To further elucidate the molecular basis of OSCC, an approach for gene expression analysis termed comparative expressed sequence hybridization (CESH) was used in the present study. This straightforward approach allows the rapid delineation of pathophysiologically interesting candidate chromosome regions by a direct detection of aberrant transcriptional activation. CESH profiling of OSCC specimens led to the identification of several novel chromosomal regions. Increased expression compared to a set of control mucosa specimens was found on 1q22-q23, 3q26.3-qter, 4q31.1-q32, 11q12-q13.2, 14q32, 18q12, 19q13.2-q13.3 and 22q13.1-q13.2. Decreased expression was found on 8p22-p23, 16p12 and 16q23-q24. Using CESH, common patterns of altered sequence expression in different OSCC samples were obtained. While some of these regions overlap with those known to be frequently altered in OSCC on the genomic level, this screen revealed novel chromosome subregions with increased transcriptional activity, which are probably independent of the genomic status of the tumor cells.

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Copy and paste a formatted citation
Spandidos Publications style
Janjetovic S, Sticht C, Knoepfle K, Joos S, Hofele C, Lichter P and Freier K: Comparative expressed sequence hybridization detects recurrent patterns of altered sequence expression in oral squamous cell carcinoma . Oncol Rep 24: 369-374, 2010.
APA
Janjetovic, S., Sticht, C., Knoepfle, K., Joos, S., Hofele, C., Lichter, P., & Freier, K. (2010). Comparative expressed sequence hybridization detects recurrent patterns of altered sequence expression in oral squamous cell carcinoma . Oncology Reports, 24, 369-374. https://doi.org/10.3892/or_00000869
MLA
Janjetovic, S., Sticht, C., Knoepfle, K., Joos, S., Hofele, C., Lichter, P., Freier, K."Comparative expressed sequence hybridization detects recurrent patterns of altered sequence expression in oral squamous cell carcinoma ". Oncology Reports 24.2 (2010): 369-374.
Chicago
Janjetovic, S., Sticht, C., Knoepfle, K., Joos, S., Hofele, C., Lichter, P., Freier, K."Comparative expressed sequence hybridization detects recurrent patterns of altered sequence expression in oral squamous cell carcinoma ". Oncology Reports 24, no. 2 (2010): 369-374. https://doi.org/10.3892/or_00000869
Copy and paste a formatted citation
x
Spandidos Publications style
Janjetovic S, Sticht C, Knoepfle K, Joos S, Hofele C, Lichter P and Freier K: Comparative expressed sequence hybridization detects recurrent patterns of altered sequence expression in oral squamous cell carcinoma . Oncol Rep 24: 369-374, 2010.
APA
Janjetovic, S., Sticht, C., Knoepfle, K., Joos, S., Hofele, C., Lichter, P., & Freier, K. (2010). Comparative expressed sequence hybridization detects recurrent patterns of altered sequence expression in oral squamous cell carcinoma . Oncology Reports, 24, 369-374. https://doi.org/10.3892/or_00000869
MLA
Janjetovic, S., Sticht, C., Knoepfle, K., Joos, S., Hofele, C., Lichter, P., Freier, K."Comparative expressed sequence hybridization detects recurrent patterns of altered sequence expression in oral squamous cell carcinoma ". Oncology Reports 24.2 (2010): 369-374.
Chicago
Janjetovic, S., Sticht, C., Knoepfle, K., Joos, S., Hofele, C., Lichter, P., Freier, K."Comparative expressed sequence hybridization detects recurrent patterns of altered sequence expression in oral squamous cell carcinoma ". Oncology Reports 24, no. 2 (2010): 369-374. https://doi.org/10.3892/or_00000869
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