Interstitial high-dose-rate brachytherapy after breast conserving surgery

  • Authors:
    • Antonio Rulli
    • Francesco Barberini
    • Michele Scialpi
    • Luciano Izzo
    • Ilaria D'Angeli
    • Stefania Gori
    • Angelo Sidoni
    • Fabio Rondelli
    • Giuseppe Noya
    • Cinzia Aristei
  • View Affiliations

  • Published online on: August 1, 2010     https://doi.org/10.3892/or_00000874
  • Pages: 417-422
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Abstract

We evaluated local recurrence, toxicity rate and cosmetic outcome in 72 patients treated with high-dose-rate (HDR) brachytherapy after breast conserving surgery. HDR brachytherapy was administered: i) as partial breast irradiation (PBI) in 64 patients with low-risk early stage breast cancer, enrolled in a phase II prospective study; ii) as PBI after a second conservative surgery as treatment of local relapse in 3 patients; iii) for delivering a boost after whole breast external beam radiotherapy in 5 patients. Implantation was done during surgery (breast conserving or re-excision to achieve adequate surgical margins), with the wound open, or postoperatively. The implant was well tolerated in all patients, so no premature catheter removal was required. At a median follow-up of 32 months (range 5-52) no local recurrence has been observed. Toxicity was very low. Cosmetic outcome was excellent/good in a high percentage of patients. Our results suggest that PBI administered with HDR brachytherapy is feasible in selected patients with low risk early stage breast carcinoma. PBI seems feasible to repeat radiotherapy after a salvage breast conserving surgery for local relapse in a second attempt to preserve the breast.

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August 2010
Volume 24 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Rulli A, Barberini F, Scialpi M, Izzo L, D'Angeli I, Gori S, Sidoni A, Rondelli F, Noya G, Aristei C, Aristei C, et al: Interstitial high-dose-rate brachytherapy after breast conserving surgery. Oncol Rep 24: 417-422, 2010
APA
Rulli, A., Barberini, F., Scialpi, M., Izzo, L., D'Angeli, I., Gori, S. ... Aristei, C. (2010). Interstitial high-dose-rate brachytherapy after breast conserving surgery. Oncology Reports, 24, 417-422. https://doi.org/10.3892/or_00000874
MLA
Rulli, A., Barberini, F., Scialpi, M., Izzo, L., D'Angeli, I., Gori, S., Sidoni, A., Rondelli, F., Noya, G., Aristei, C."Interstitial high-dose-rate brachytherapy after breast conserving surgery". Oncology Reports 24.2 (2010): 417-422.
Chicago
Rulli, A., Barberini, F., Scialpi, M., Izzo, L., D'Angeli, I., Gori, S., Sidoni, A., Rondelli, F., Noya, G., Aristei, C."Interstitial high-dose-rate brachytherapy after breast conserving surgery". Oncology Reports 24, no. 2 (2010): 417-422. https://doi.org/10.3892/or_00000874