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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2010 Volume 24 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2010 Volume 24 Issue 2

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Article

AF1q enhancement of γ irradiation-induced apoptosis by up-regulation of BAD expression via NF-κB in human squamous carcinoma A431 cells

  • Authors:
    • Ngai Na Co
    • Wing Pui Tsang
    • Tsun Yee Tsang
    • Chi Lam Au Yeung
    • Pak Lun Yau
    • Siu Kai Kong
    • Tim Tak Kwok

  • View Affiliations / Copyright

    Affiliations: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, P.R. China
  • Pages: 547-554
    |
    Published online on: August 1, 2010
       https://doi.org/10.3892/or_00000891
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Abstract

BAD (BCL-2 antagonist of cell death) is a pro-apoptotic BCL-2 family protein that plays a critical role in the regulation of apoptotic response. This study presents direct evidence that AF1q increased the radiation-induced apoptosis through up-regulation of BAD in human squamous carcinoma A431 cells and the key transcription factor involved is NF-κB. The minimal promoter sequence of BAD was identified; the activity was increased in AF1q stable transfectants and decreased upon AF1q siRNA transfection. The NF-κB consensus binding sequence is detected on BAD promoter. Inactivation of NF-κB by NF-κB inhibitor Bay 11-7082 or NF-κB p65 siRNA suppressed the expression and promoter activity of BAD; the suppression is more obvious in AF1q stable transfectants which also have an elevated NF-κB level. Mutation of putative NF-κB motif decreased the BAD promoter activity. The binding of NF-κB to the BAD promoter was confirmed by chromatin-immunoprecipitation. These findings indicate that AF1q up-regulation of BAD is through its effect on NF-κB and this may hint of its oncogenic mechanism in cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Co NN, Tsang WP, Tsang TY, Yeung CL, Yau PL, Kong SK and Kwok TT: AF1q enhancement of γ irradiation-induced apoptosis by up-regulation of BAD expression via NF-κB in human squamous carcinoma A431 cells. Oncol Rep 24: 547-554, 2010.
APA
Co, N.N., Tsang, W.P., Tsang, T.Y., Yeung, C.L., Yau, P.L., Kong, S.K., & Kwok, T.T. (2010). AF1q enhancement of γ irradiation-induced apoptosis by up-regulation of BAD expression via NF-κB in human squamous carcinoma A431 cells. Oncology Reports, 24, 547-554. https://doi.org/10.3892/or_00000891
MLA
Co, N. N., Tsang, W. P., Tsang, T. Y., Yeung, C. L., Yau, P. L., Kong, S. K., Kwok, T. T."AF1q enhancement of γ irradiation-induced apoptosis by up-regulation of BAD expression via NF-κB in human squamous carcinoma A431 cells". Oncology Reports 24.2 (2010): 547-554.
Chicago
Co, N. N., Tsang, W. P., Tsang, T. Y., Yeung, C. L., Yau, P. L., Kong, S. K., Kwok, T. T."AF1q enhancement of γ irradiation-induced apoptosis by up-regulation of BAD expression via NF-κB in human squamous carcinoma A431 cells". Oncology Reports 24, no. 2 (2010): 547-554. https://doi.org/10.3892/or_00000891
Copy and paste a formatted citation
x
Spandidos Publications style
Co NN, Tsang WP, Tsang TY, Yeung CL, Yau PL, Kong SK and Kwok TT: AF1q enhancement of γ irradiation-induced apoptosis by up-regulation of BAD expression via NF-κB in human squamous carcinoma A431 cells. Oncol Rep 24: 547-554, 2010.
APA
Co, N.N., Tsang, W.P., Tsang, T.Y., Yeung, C.L., Yau, P.L., Kong, S.K., & Kwok, T.T. (2010). AF1q enhancement of γ irradiation-induced apoptosis by up-regulation of BAD expression via NF-κB in human squamous carcinoma A431 cells. Oncology Reports, 24, 547-554. https://doi.org/10.3892/or_00000891
MLA
Co, N. N., Tsang, W. P., Tsang, T. Y., Yeung, C. L., Yau, P. L., Kong, S. K., Kwok, T. T."AF1q enhancement of γ irradiation-induced apoptosis by up-regulation of BAD expression via NF-κB in human squamous carcinoma A431 cells". Oncology Reports 24.2 (2010): 547-554.
Chicago
Co, N. N., Tsang, W. P., Tsang, T. Y., Yeung, C. L., Yau, P. L., Kong, S. K., Kwok, T. T."AF1q enhancement of γ irradiation-induced apoptosis by up-regulation of BAD expression via NF-κB in human squamous carcinoma A431 cells". Oncology Reports 24, no. 2 (2010): 547-554. https://doi.org/10.3892/or_00000891
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