CD98 expression is associated with the grade of malignancy in thymic epithelial tumors

Kaira,Kyoichi; Takahashi,Toshiaki; Abe,Masato; Akamatsu,Hiroaki; Nakagawa,Kazuo; Ohde,Yasuhisa; Okumura,Takehiro; Murakami,Haruyasu; Tsuya,Asuka; Nakamura,Yukiko; Naito,Tateaki; Kondo,Haruhiko; Nakajima,Takashi; Endo,Masahiro; Yamamoto,Nobuyuki

doi:10.3892/or_00000931

October 2010 Volume 24 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October 2010 Volume 24 Issue 4

Full Size Image

Article

CD98 expression is associated with the grade of malignancy in thymic epithelial tumors

Authors:
- Kyoichi Kaira
- Toshiaki Takahashi
- Masato Abe
- Hiroaki Akamatsu
- Kazuo Nakagawa
- Yasuhisa Ohde
- Takehiro Okumura
- Haruyasu Murakami
- Asuka Tsuya
- Yukiko Nakamura
- Tateaki Naito
- Haruhiko Kondo
- Takashi Nakajima
- Masahiro Endo
- Nobuyuki Yamamoto
View Affiliations / Copyright

Affiliations: Division of Thoracic Oncology, Shizuoka Cancer Center, Sunto-gun, Shizuoka 411-8777, Japan. kkaira1970@yahoo.co.jp
Pages: 861-867
|
Published online on: October 1, 2010

https://doi.org/10.3892/or_00000931
Expand metrics +

Abstract

CD98 has been associated with tumor growth and is highly expressed in human neoplasms. The aim of this study was to evaluate the clinicopathological significance of CD98 expression in thymic epithelial tumors. Forty-nine patients with thymic epithelial tumors were included in this study. Tumor sections were stained by immunohistochemistry for CD98; vascular endothelial growth factor (VEGF); micro-vessels (CD31 and CD34); cell cycle control marker (p53); and apoptosis marker (Bcl-2). CD98 expression for low-risk thymomas, high-risk thymomas, and thymic carcinomas were 1 (4%) of 27, 9 (82%) of 11, and 11 (100%) of 11, respectively. There was positive correlation between CD98 and VEGF (p<0.001), microvessel density (CD31 and CD34) (p<0.001) and p53 (p<0.001). However, Bcl-2 showed no positive correlation with CD98 expression. The expression of CD98 were also significantly associated with the grade of malignancy in thymic epithelial tumors. Multivariate analysis revealed that overexpression of CD98 was a significant independent factor predicting a poor outcome in thymic epithelial tumors. CD98 expression was associated with the grade of malignancy in thymic epithelial tumors. Moreover, CD98 expression was closely correlated with angiogenesis and cell cycle control, and was useful for predicting poor outcome.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

CD98 expression is associated with the grade of malignancy in thymic epithelial tumors

This article is mentioned in:

Abstract

Related Articles