CD98 expression is associated with the grade of malignancy in thymic epithelial tumors

  • Authors:
    • Kyoichi Kaira
    • Toshiaki Takahashi
    • Masato Abe
    • Hiroaki Akamatsu
    • Kazuo Nakagawa
    • Yasuhisa Ohde
    • Takehiro Okumura
    • Haruyasu Murakami
    • Asuka Tsuya
    • Yukiko Nakamura
    • Tateaki Naito
    • Haruhiko Kondo
    • Takashi Nakajima
    • Masahiro Endo
    • Nobuyuki Yamamoto
  • View Affiliations

  • Published online on: October 1, 2010     https://doi.org/10.3892/or_00000931
  • Pages: 861-867
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Abstract

CD98 has been associated with tumor growth and is highly expressed in human neoplasms. The aim of this study was to evaluate the clinicopathological significance of CD98 expression in thymic epithelial tumors. Forty-nine patients with thymic epithelial tumors were included in this study. Tumor sections were stained by immunohistochemistry for CD98; vascular endothelial growth factor (VEGF); micro-vessels (CD31 and CD34); cell cycle control marker (p53); and apoptosis marker (Bcl-2). CD98 expression for low-risk thymomas, high-risk thymomas, and thymic carcinomas were 1 (4%) of 27, 9 (82%) of 11, and 11 (100%) of 11, respectively. There was positive correlation between CD98 and VEGF (p<0.001), microvessel density (CD31 and CD34) (p<0.001) and p53 (p<0.001). However, Bcl-2 showed no positive correlation with CD98 expression. The expression of CD98 were also significantly associated with the grade of malignancy in thymic epithelial tumors. Multivariate analysis revealed that overexpression of CD98 was a significant independent factor predicting a poor outcome in thymic epithelial tumors. CD98 expression was associated with the grade of malignancy in thymic epithelial tumors. Moreover, CD98 expression was closely correlated with angiogenesis and cell cycle control, and was useful for predicting poor outcome.

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October 2010
Volume 24 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kaira K, Takahashi T, Abe M, Akamatsu H, Nakagawa K, Ohde Y, Okumura T, Murakami H, Tsuya A, Nakamura Y, Nakamura Y, et al: CD98 expression is associated with the grade of malignancy in thymic epithelial tumors . Oncol Rep 24: 861-867, 2010
APA
Kaira, K., Takahashi, T., Abe, M., Akamatsu, H., Nakagawa, K., Ohde, Y. ... Yamamoto, N. (2010). CD98 expression is associated with the grade of malignancy in thymic epithelial tumors . Oncology Reports, 24, 861-867. https://doi.org/10.3892/or_00000931
MLA
Kaira, K., Takahashi, T., Abe, M., Akamatsu, H., Nakagawa, K., Ohde, Y., Okumura, T., Murakami, H., Tsuya, A., Nakamura, Y., Naito, T., Kondo, H., Nakajima, T., Endo, M., Yamamoto, N." CD98 expression is associated with the grade of malignancy in thymic epithelial tumors ". Oncology Reports 24.4 (2010): 861-867.
Chicago
Kaira, K., Takahashi, T., Abe, M., Akamatsu, H., Nakagawa, K., Ohde, Y., Okumura, T., Murakami, H., Tsuya, A., Nakamura, Y., Naito, T., Kondo, H., Nakajima, T., Endo, M., Yamamoto, N." CD98 expression is associated with the grade of malignancy in thymic epithelial tumors ". Oncology Reports 24, no. 4 (2010): 861-867. https://doi.org/10.3892/or_00000931