The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk

  • Authors:
    • Bruno Costa Gomes
    • Susana Nunes Silva
    • Ana Paula Azevedo
    • Isabel Manita
    • Octávia Monteiro Gil
    • Teresa Cruz Ferreira
    • Edward Limbert
    • José Rueff
    • Jorge Francisco Gaspar
  • View Affiliations

  • Published online on: October 1, 2010     https://doi.org/10.3892/or_00000958
  • Pages: 1079-1085
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Variations, such as single nucleotide polymorphisms (SNPs) in DNA damage repair genes have been pointed out as possible factors to cancer predisposition. Ionizing radiation (IR) induces DNA double strand breaks (DSBs) and is the main recognized risk factor for thyroid cancer. However, most of the patients do not show chronic contact with IR and the other factors have non-concordant data. Thus, thyroid cancer could be due to gene variations in association with certain exogenous factors. One of the pathways that repair DSBs is DNA non-homologous end-joining (NHEJ) that comprises several polymorphic genes. We intend to study the role of polymorphic variants in XRCC4, LIG4 and Ku80 genes, since there is scarcity of data on the role of these genes in thyroid cancer susceptibility. We carried out a hospital-based case-control study in a Caucasian Portuguese population (109 patients and 217 controls) to estimate the potential role of the XRCC4 (N298S and T134I), LIG4 (T9I) and Ku80 (Ex21-238G↷A, Ex21+338T↷C, Ex21-352C↷A, Ex21+466A↷G) polymorphisms in the individual susceptibility for this disease. The results here reported do not associate these polymorphisms with susceptibility for non-familial thyroid cancer. However, when the data were analyzed according to the type of tumour, significant results for Ku80 Ex21-238G↷A and Ex21+466A↷G were found for papillary tumours (adjusted OR = 2.281; 95% CI =; 1.063-4.894; P=0.034). Taken together these results suggest that some of these variants in NHEJ genes can contribute to thyroid cancer susceptibility. However, further studies with a larger sample size will be needed to support our results.

Related Articles

Journal Cover

October 2010
Volume 24 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gomes BC, Silva SN, Azevedo AP, Manita I, Gil OM, Ferreira TC, Limbert E, Rueff J and Gaspar JF: The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk . Oncol Rep 24: 1079-1085, 2010
APA
Gomes, B.C., Silva, S.N., Azevedo, A.P., Manita, I., Gil, O.M., Ferreira, T.C. ... Gaspar, J.F. (2010). The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk . Oncology Reports, 24, 1079-1085. https://doi.org/10.3892/or_00000958
MLA
Gomes, B. C., Silva, S. N., Azevedo, A. P., Manita, I., Gil, O. M., Ferreira, T. C., Limbert, E., Rueff, J., Gaspar, J. F."The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk ". Oncology Reports 24.4 (2010): 1079-1085.
Chicago
Gomes, B. C., Silva, S. N., Azevedo, A. P., Manita, I., Gil, O. M., Ferreira, T. C., Limbert, E., Rueff, J., Gaspar, J. F."The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk ". Oncology Reports 24, no. 4 (2010): 1079-1085. https://doi.org/10.3892/or_00000958