Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer

  • Authors:
    • Jie Zhang
    • Xiao-Min Niu
    • Mei-Lin Liao
    • Yun Liu
    • Hui-Fang Sha
    • Yi Zhao
    • Yong-Feng Yu
    • Qiang Tan
    • Jia-Qing Xiang
    • Jing Fang
    • Dan-Dan Lv
    • Xue-Bing Li
    • Shun Lu
    • Hai-Quan Chen
  • View Affiliations

  • Published online on: November 1, 2010     https://doi.org/10.3892/or_00000971
  • Pages: 1185-1192
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Abstract

Disseminated cancer cells may initially require local nutrients and growth factors to thrive and survive in bone marrow. However, data on the influence of bone marrow derived cells (BMDC, also called bone stromal cells in some publications) on lung cancer cells is largely unexplored. This study explored the mechanism of how bone stromal factors contribute to the bone tropism in lung cancer. The difference among lung cancer cell lines in their abilities to metastasize to bone was found using the SCID animal model. Supernatant of bone marrow aspiration (BM) and condition medium from human bone stromal cells (BSC) were used to study the activity of bone stromal factors. We found bone stromal factors significantly increased the proliferation, invasion, adhesion and expression of angiogenosis-related factors, and inhibited the apoptosis for high bone metastasis H460 lung cancer cells. These biologic effects were not seen in SPC-A1 or A549 cells, which are low bone metastasis lung cancer cells. Adhesion of H460 cells to surface coated with bone stromal cells can activate some signal transduction pathways, and alter the expression of adhesion associated factors, including integrin β 3 and ADAMTS-1, two potential targets related with bone metastasis. We concluded that bone marrow derived cells had a profound effect on biological behavior of lung cancers, therefore favoring the growth of lung cancer cells in bone.

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November 2010
Volume 24 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang J, Niu X, Liao M, Liu Y, Sha H, Zhao Y, Yu Y, Tan Q, Xiang J, Fang J, Fang J, et al: Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer . Oncol Rep 24: 1185-1192, 2010
APA
Zhang, J., Niu, X., Liao, M., Liu, Y., Sha, H., Zhao, Y. ... Chen, H. (2010). Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer . Oncology Reports, 24, 1185-1192. https://doi.org/10.3892/or_00000971
MLA
Zhang, J., Niu, X., Liao, M., Liu, Y., Sha, H., Zhao, Y., Yu, Y., Tan, Q., Xiang, J., Fang, J., Lv, D., Li, X., Lu, S., Chen, H."Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer ". Oncology Reports 24.5 (2010): 1185-1192.
Chicago
Zhang, J., Niu, X., Liao, M., Liu, Y., Sha, H., Zhao, Y., Yu, Y., Tan, Q., Xiang, J., Fang, J., Lv, D., Li, X., Lu, S., Chen, H."Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer ". Oncology Reports 24, no. 5 (2010): 1185-1192. https://doi.org/10.3892/or_00000971