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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2010 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2010 Volume 24 Issue 6

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Article

Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells

  • Authors:
    • Yun-Kyoung Lee
    • Ock Jin Park

  • View Affiliations / Copyright

    Affiliations: Department of Food and Nutrition, Hannam University Daedeok Valley Campus, Yuseong-gu, Daejeon 305-811, Republic of Korea
  • Pages: 1493-1497
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/or_00001010
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Abstract

In lieu of elucidating bidirectional connecting mechanism between AMP-activated protein kinase (AMPK) and survival signal Akt we applied MCF-7 breast cancer cells to determine whether AMPK modulation alters Akt signals and vice versa. Suppression of Akt activities with a synthetic Akt inhibitor alleviated AMPK activities suggesting that Akt is capable of inhibiting AMPK. Also the activation of AMPK with quercetin strongly abrogated Akt activities. Treating cancer cells with AMPK siRNA or Compound C resulted in marked increment of Akt dephosphorylation indicating that AMPK has antagonistic activities towards Akt. However, quercetin exerted Akt inhibitory activities in the absence of AMPK activation. Quercetin induced partial co-localization of phospho-Akt and phospho-AMPK in the nucleus even though their interaction seems to be indirect since the immunoprecipitation data indicate there was no direct binding between total Akt and AMPK. These results suggest there is a mutual suppressive interaction between AMPK and Akt. The investigation of mutual suppression between Akt and AMPK by chemo-preventive agents such as quercetin may provide a mechanistic rational for controlling breast tumor cell growth.

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Copy and paste a formatted citation
Spandidos Publications style
Lee Y and Park OJ: Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells . Oncol Rep 24: 1493-1497, 2010.
APA
Lee, Y., & Park, O.J. (2010). Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells . Oncology Reports, 24, 1493-1497. https://doi.org/10.3892/or_00001010
MLA
Lee, Y., Park, O. J."Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells ". Oncology Reports 24.6 (2010): 1493-1497.
Chicago
Lee, Y., Park, O. J."Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells ". Oncology Reports 24, no. 6 (2010): 1493-1497. https://doi.org/10.3892/or_00001010
Copy and paste a formatted citation
x
Spandidos Publications style
Lee Y and Park OJ: Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells . Oncol Rep 24: 1493-1497, 2010.
APA
Lee, Y., & Park, O.J. (2010). Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells . Oncology Reports, 24, 1493-1497. https://doi.org/10.3892/or_00001010
MLA
Lee, Y., Park, O. J."Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells ". Oncology Reports 24.6 (2010): 1493-1497.
Chicago
Lee, Y., Park, O. J."Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells ". Oncology Reports 24, no. 6 (2010): 1493-1497. https://doi.org/10.3892/or_00001010
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