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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2010 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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December 2010 Volume 24 Issue 6

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Article

Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway

  • Authors:
    • Frank Bergmann
    • Sandhya Singh
    • Sara Michel
    • Christoph Kahlert
    • Peter Schirmacher
    • Burkhard Helmke
    • Magnus Von Knebel Doeberitz
    • Matthias Kloor
    • Hendrik Bläker

  • View Affiliations / Copyright

    Affiliations: Department of General Pathology, Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
  • Pages: 1535-1539
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/or_00001015
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Abstract

Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma. Recent studies have demonstrated aberrant CpG island methylation (CIM) in chronic inflammation, aging and cancer. We hypothesized that CIM may link CD to small bowel carcinogenesis. We determined microsatellite instability (MSI), CIM, and expression of MLH1 and MGMT in 3 CD-associated small bowel carcinomas and corresponding non-neoplastic mucosa. The results were compared to those of small bowel mucosa from CD patients without carcinoma and 20 small bowel carcinomas from a non-CD origin. A high level CIM/MSI phenotype was found in all of the 3 CD-associated carcinomas and was associated with loss of MLH1 expression due to hypermethylation of the MLH1 promoter. This phenotype was noted in only 2 of the 20 investigated non-CD-associated carcinomas. Low-level CIM was already detectable in 9 of the 12 non-neoplastic mucosa samples of CD patients and in non-CD-associated carcinomas of elderly patients. In conclusion, our data reveal that the high-level CIM/MSI pathway is typical of CD-associated small bowel carcinomas and indicate that aberrant CpG island methylation links CD and carcinogenesis. The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI.

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Copy and paste a formatted citation
Spandidos Publications style
Bergmann F, Singh S, Michel S, Kahlert C, Schirmacher P, Helmke B, Von Knebel Doeberitz M, Kloor M and Bläker H: Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway . Oncol Rep 24: 1535-1539, 2010.
APA
Bergmann, F., Singh, S., Michel, S., Kahlert, C., Schirmacher, P., Helmke, B. ... Bläker, H. (2010). Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway . Oncology Reports, 24, 1535-1539. https://doi.org/10.3892/or_00001015
MLA
Bergmann, F., Singh, S., Michel, S., Kahlert, C., Schirmacher, P., Helmke, B., Von Knebel Doeberitz, M., Kloor, M., Bläker, H."Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway ". Oncology Reports 24.6 (2010): 1535-1539.
Chicago
Bergmann, F., Singh, S., Michel, S., Kahlert, C., Schirmacher, P., Helmke, B., Von Knebel Doeberitz, M., Kloor, M., Bläker, H."Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway ". Oncology Reports 24, no. 6 (2010): 1535-1539. https://doi.org/10.3892/or_00001015
Copy and paste a formatted citation
x
Spandidos Publications style
Bergmann F, Singh S, Michel S, Kahlert C, Schirmacher P, Helmke B, Von Knebel Doeberitz M, Kloor M and Bläker H: Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway . Oncol Rep 24: 1535-1539, 2010.
APA
Bergmann, F., Singh, S., Michel, S., Kahlert, C., Schirmacher, P., Helmke, B. ... Bläker, H. (2010). Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway . Oncology Reports, 24, 1535-1539. https://doi.org/10.3892/or_00001015
MLA
Bergmann, F., Singh, S., Michel, S., Kahlert, C., Schirmacher, P., Helmke, B., Von Knebel Doeberitz, M., Kloor, M., Bläker, H."Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway ". Oncology Reports 24.6 (2010): 1535-1539.
Chicago
Bergmann, F., Singh, S., Michel, S., Kahlert, C., Schirmacher, P., Helmke, B., Von Knebel Doeberitz, M., Kloor, M., Bläker, H."Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway ". Oncology Reports 24, no. 6 (2010): 1535-1539. https://doi.org/10.3892/or_00001015
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