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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2010 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2010 Volume 24 Issue 6

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Article

Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells

  • Authors:
    • Shufang Wu
    • Bo Zhou
    • Lin Xu
    • Hongzhi Sun

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710060, P.R. China. shufangw@hotmail.com
  • Pages: 1541-1550
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/or_00001016
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Abstract

Despite significant homology between IRS-1 and IRS-2, recent studies have revealed distinct functions for these adaptor proteins in regulating breast cancer progression. Thus far, most of the studies on breast cancer have focused upon IRS-1, the biological pattern of IRS-2 is limited. We demonstrated that depletion of endogenous IRS-2 by antisense strategies impaired cell proliferation after serum withdrawal, blunted PI3K/Akt and NF-κB activation in IGF-1 induced response in MCF-7 and BT-20 breast cancer cells. In addition, IGF-1 promote nuclear translocation of IRS-2 and NF-κB in MCF-7 and BT-20 cells. Nuclear IRS-2 interaction with NF-κB-p65 and PI3K binding tyrosine residues of IRS-2 are crucial for the NF-κB activities. Moreover, nuclear IRS-2 is recruited to the cyclin D1 promoter both in MCF-7 and BT-20 cells. The selective inhibition of NF-κB-65 abolished the occupancy of IRS-2 to the cyclin D1 promoters. Our studies suggest that IRS-2 plays a significant role by activating, at least in part, NF-κB via PI3K/Akt pathway in IGF-1-induced responses in breast cancer cells and the crosstalk between nuclear IRS-2 and NF-κB might be responsible for transcriptional progression of the breast cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Wu S, Zhou B, Xu L and Sun H: Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells . Oncol Rep 24: 1541-1550, 2010.
APA
Wu, S., Zhou, B., Xu, L., & Sun, H. (2010). Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells . Oncology Reports, 24, 1541-1550. https://doi.org/10.3892/or_00001016
MLA
Wu, S., Zhou, B., Xu, L., Sun, H."Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells ". Oncology Reports 24.6 (2010): 1541-1550.
Chicago
Wu, S., Zhou, B., Xu, L., Sun, H."Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells ". Oncology Reports 24, no. 6 (2010): 1541-1550. https://doi.org/10.3892/or_00001016
Copy and paste a formatted citation
x
Spandidos Publications style
Wu S, Zhou B, Xu L and Sun H: Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells . Oncol Rep 24: 1541-1550, 2010.
APA
Wu, S., Zhou, B., Xu, L., & Sun, H. (2010). Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells . Oncology Reports, 24, 1541-1550. https://doi.org/10.3892/or_00001016
MLA
Wu, S., Zhou, B., Xu, L., Sun, H."Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells ". Oncology Reports 24.6 (2010): 1541-1550.
Chicago
Wu, S., Zhou, B., Xu, L., Sun, H."Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells ". Oncology Reports 24, no. 6 (2010): 1541-1550. https://doi.org/10.3892/or_00001016
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