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Review Open Access

Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review)

  • Authors:
    • Denisa Margina
    • George Mihai Nițulescu
    • Anca Ungurianu
    • Robin Mesnage
    • Marina Goumenou
    • Dimosthenis A. Sarigiannis
    • Michael Aschner
    • Demetrios A. Spandidos
    • Elisavet A. Renieri
    • Antonio F. Hernández
    • Aristidis Tsatsakis
  • View Affiliations / Copyright

    Affiliations: ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Gene Expression and Therapy Group, Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom, Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71409 Heraklion, Greece, Department of Chemical Engineering, Environmental Engineering Laboratory, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10463, USA, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71409 Heraklion, Greece, Centre of Toxicology Science and Research, School of Medicine, University of Crete, 71409 Heraklion, Greece, Department of Legal Medicine and Toxicology, University of Granada School of Medicine, Granada, Spain
    Copyright: © Margina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 157-164
    |
    Published online on: August 5, 2019
       https://doi.org/10.3892/wasj.2019.17
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Abstract

Research over the past years has indicated that chronic human exposure to very low doses of various chemical species in mixtures and administered via different routes (percutaneous, orally, etc.) should be the main focus of new biochemical and toxicological studies. Humans have daily contact with various chemicals, such as food additives, pesticides from fruits/vegetables, antibiotics (and other veterinary drugs) from meat, different types of preservatives from cosmetics, to name a few. Simultaneous exposure to this wide array of chemicals does not produce immediate effects, but summative effect/s over time that may be clinically manifested several years thereafter. Classical animal studies designed to test the toxic outcome of a single chemical are not suitable to assess, and then extrapolate to humans, the effects of a whole mixture of chemicals. Testing the aftermath of a combination of chemicals, at low doses, around or below the no observed adverse effect is stressed by many toxicologists. Thus, there is a need to reformulate the design of biochemical and toxicological studies in order to perform real‑life risk simulation. This review discuss the potential use of computational methods as a complementary tool for in vitro and in vivo toxicity tests with a high predictive potential that could contribute to reduce animal testing, cost and time, when assessing the effects of chemical combinations. This review focused on the use of these methods to predict the potential endocrine disrupting activity of a mixture of chemicals.
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Copy and paste a formatted citation
Spandidos Publications style
Margina D, Nițulescu GM, Ungurianu A, Mesnage R, Goumenou M, Sarigiannis DA, Aschner M, Spandidos DA, Renieri E , Hernández AF, Hernández AF, et al: Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review). World Acad Sci J 1: 157-164, 2019.
APA
Margina, D., Nițulescu, G.M., Ungurianu, A., Mesnage, R., Goumenou, M., Sarigiannis, D.A. ... Tsatsakis, A. (2019). Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review). World Academy of Sciences Journal, 1, 157-164. https://doi.org/10.3892/wasj.2019.17
MLA
Margina, D., Nițulescu, G. M., Ungurianu, A., Mesnage, R., Goumenou, M., Sarigiannis, D. A., Aschner, M., Spandidos, D. A., Renieri, E. ., Hernández, A. F., Tsatsakis, A."Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review)". World Academy of Sciences Journal 1.4 (2019): 157-164.
Chicago
Margina, D., Nițulescu, G. M., Ungurianu, A., Mesnage, R., Goumenou, M., Sarigiannis, D. A., Aschner, M., Spandidos, D. A., Renieri, E. ., Hernández, A. F., Tsatsakis, A."Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review)". World Academy of Sciences Journal 1, no. 4 (2019): 157-164. https://doi.org/10.3892/wasj.2019.17
Copy and paste a formatted citation
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Spandidos Publications style
Margina D, Nițulescu GM, Ungurianu A, Mesnage R, Goumenou M, Sarigiannis DA, Aschner M, Spandidos DA, Renieri E , Hernández AF, Hernández AF, et al: Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review). World Acad Sci J 1: 157-164, 2019.
APA
Margina, D., Nițulescu, G.M., Ungurianu, A., Mesnage, R., Goumenou, M., Sarigiannis, D.A. ... Tsatsakis, A. (2019). Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review). World Academy of Sciences Journal, 1, 157-164. https://doi.org/10.3892/wasj.2019.17
MLA
Margina, D., Nițulescu, G. M., Ungurianu, A., Mesnage, R., Goumenou, M., Sarigiannis, D. A., Aschner, M., Spandidos, D. A., Renieri, E. ., Hernández, A. F., Tsatsakis, A."Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review)". World Academy of Sciences Journal 1.4 (2019): 157-164.
Chicago
Margina, D., Nițulescu, G. M., Ungurianu, A., Mesnage, R., Goumenou, M., Sarigiannis, D. A., Aschner, M., Spandidos, D. A., Renieri, E. ., Hernández, A. F., Tsatsakis, A."Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review)". World Academy of Sciences Journal 1, no. 4 (2019): 157-164. https://doi.org/10.3892/wasj.2019.17
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