Open Access

Other forms of oxidized LDL: Emerging functions (Review)

  • Authors:
    • Jalil Daher
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  • Published online on: April 13, 2020     https://doi.org/10.3892/wasj.2020.45
  • ArticleNumber: 4
  • Copyright: © Daher et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Atherosclerosis is a chronic inflammatory disease related to subendothelial accumulation of the oxidized forms of low-density lipoproteins (LDLs). The mechanisms through which LDLs are oxidized in the system remain controversial. In the present review article, an LDL oxidized by myeloperoxidase is proposed as the most pathophysiological model of LDL oxidation. This would facilitate future studies and may aid in the development of more effective methods with which to elucidate the molecular pathways that are promoted by myeloperoxidase-oxidized LDLs (Mox-LDL) in endothelial cell dysfunction and macrophage activation. This may also aid scientists in the further understanding of the molecular pathobiology of atherosclerosis and in the improvement of treatment methods.
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May 2020
Volume 2 Issue 3

Print ISSN: 2632-2900
Online ISSN:2632-2919

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APA
Daher, J. (2020). Other forms of oxidized LDL: Emerging functions (Review). World Academy of Sciences Journal, 2, 4. https://doi.org/10.3892/wasj.2020.45
MLA
Daher, J."Other forms of oxidized LDL: Emerging functions (Review)". World Academy of Sciences Journal 2.3 (2020): 4.
Chicago
Daher, J."Other forms of oxidized LDL: Emerging functions (Review)". World Academy of Sciences Journal 2, no. 3 (2020): 4. https://doi.org/10.3892/wasj.2020.45