Open Access

ADAM3A deletion is associated with high‑risk features in acute lymphoblastic leukemia

  • Authors:
    • Jéssica Almeida Batista‑Gomes
    • Fernando Augusto Rodrigues Mello Jr
    • Michel Platini Caldas De Souza
    • Alayde Vieira Wanderley
    • Edivaldo Herculano Correa De Oliveira
    • André Salim Khayat
  • View Affiliations

  • Published online on: June 19, 2020     https://doi.org/10.3892/wasj.2020.56
  • Article Number: 15
  • Copyright: © Batista‑Gomes et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute lymphoblastic leukemia (ALL) is a malignant proliferation of lymphoid cells characterized as a heterogeneous disease at demographic, clinical and genetic levels. Copy number alterations (CNAs) are defined as secondary abnormalities subsequently required for the establishment of the leukemic clone. As the risk stratification of ALL is partly based on genetic analysis, different genomic tools are increasingly being used to screen for novel genetic biomarkers. In the present study, through array‑comparative genomic hybridization (aCGH), CNAs in 12 ADAM genes were investigated and their association with clinicopathological features in 16 pediatric ALL cases was evaluated. The most frequent amplification was found in ADAM6 (94%), and deletion was more common in ADAM3A (31%). ADAM3A deletion were associated with male patients (P=0.025), leukocytosis (P=0.007) and high‑risk cases (P=0.004). However, the effects of aberration on ADAM genes still needs to be fully defined in hematological malignancies, particularly in leukemia. The findings of the present study corroborate those of previous studies that suggest that ADAM genes play a role in carcinogenesis.
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September-October 2020
Volume 2 Issue 5

Print ISSN: 2632-2900
Online ISSN:2632-2919

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Spandidos Publications style
Batista‑Gomes JA, Mello Jr FA, De Souza MP, Wanderley AV, De Oliveira EH and Khayat AS: <em>ADAM3A</em> deletion is associated with high‑risk features in acute lymphoblastic leukemia. World Acad Sci J 2: 15, 2020
APA
Batista‑Gomes, J.A., Mello Jr, F.A., De Souza, M.P., Wanderley, A.V., De Oliveira, E.H., & Khayat, A.S. (2020). <em>ADAM3A</em> deletion is associated with high‑risk features in acute lymphoblastic leukemia. World Academy of Sciences Journal, 2, 15. https://doi.org/10.3892/wasj.2020.56
MLA
Batista‑Gomes, J. A., Mello Jr, F. A., De Souza, M. P., Wanderley, A. V., De Oliveira, E. H., Khayat, A. S."<em>ADAM3A</em> deletion is associated with high‑risk features in acute lymphoblastic leukemia". World Academy of Sciences Journal 2.5 (2020): 15.
Chicago
Batista‑Gomes, J. A., Mello Jr, F. A., De Souza, M. P., Wanderley, A. V., De Oliveira, E. H., Khayat, A. S."<em>ADAM3A</em> deletion is associated with high‑risk features in acute lymphoblastic leukemia". World Academy of Sciences Journal 2, no. 5 (2020): 15. https://doi.org/10.3892/wasj.2020.56