Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
World Academy of Sciences Journal
Join Editorial Board Propose a Special Issue
Print ISSN: 2632-2900 Online ISSN: 2632-2919
Journal Cover
November-December 2020 Volume 2 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-December 2020 Volume 2 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

High‑flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID‑19: A report of three cases and a literature review

  • Authors:
    • Andrea Marino
    • Alessio Pampaloni
    • Daniele Scuderi
    • Federica Cosentino
    • Vittoria Moscatt
    • Manuela Ceccarelli
    • Maria Gussio
    • Benedetto Maurizio Celesia
    • Roberto Bruno
    • Savino Borraccino
    • Giuseppe Nunnari
    • Bruno Cacopardo
  • View Affiliations / Copyright

    Affiliations: Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, I‑95122 Catania, Italy, Unit of Intensive Care, ARNAS Garibaldi Hospital, I‑95122 Catania, Italy, Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, I‑98124 Messina, Italy
    Copyright: © Marino et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 23
    |
    Published online on: August 18, 2020
       https://doi.org/10.3892/wasj.2020.64
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Since late 2019, SARS‑CoV2 has spread worldwide, leading the WHO to declare a pandemic state. Italy was deeply affected by the virus, particularly North Italy. Several molecules have been tested for the treatment of coronavirus disease (COVID‑19), comparing the treatment efficacy and collateral effects. To date, no antiviral drugs have been approved for the treatment of the COVID‑19 viral phase or for the inflammatory phase. Undoubtedly, oxygen support plays a key role in the management of patients affected by this virus. The present study reports the cases of 3 patients critically ill with COVID‑19. Despite antiviral therapy, their clinical conditions deteriorated a few days following admission, particularly as regards respiratory performance, together with chest X‑ray findings and arterial blood gas parameters. The levels of inflammatory markers were also elevated. The patients were treated with high‑flow nasal cannula (HFNC) oxygenation along with a double dose of tocilizumab. A few days following HFNC and tocilizumab administration, the respiratory rates and arterial blood gas data were ameliorated along with chest X‑ray results. The use of HFNC was then slowly reduced until it was terminated, with the patients achieving a successful discharge. On the whole, as presented herein, it is indisputable more data and guidelines for COVID‑19 therapies are warranted in order to guide clinicians as to the appropriate clinical treatment which will guarantee an optimal therapeutic response.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, et al: A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 382:727–733. 2020.PubMed/NCBI View Article : Google Scholar

2 

WHO. Coronavirus (COVID-19) events as they happen. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen. 2020. Access date, April 26, 2020.

3 

WHO: Events as they happen. Rolling updates on coronavirus disease (COVID-19). WHO, 2020.

4 

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, et al: Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 323:1061–1069. 2020.PubMed/NCBI View Article : Google Scholar

5 

Riccardo F, Ajelli M, Andrianou X, Bella A, Del Manso M, Fabiani M, Bellino S, Boros S, Urdiales AM, et al: Epidemiological characteristics of COVID-19 cases in Italy and estimates of the reproductive numbers one month into the epidemic. medRxiv, 2020. doi: https://doi.org/10.1101/2020.04.08.20056861.

6 

Bhimraj A, Morgan RL, Shumaker AH, Lavergne V, Baden L, Cheng VC, Edwards KM, Gandhi R, Muller WJ, O'Horo JC, et al: Infectious diseases society of America Guidelines on the Treatment and Management of Patients with COVID-19. Clin Infect Dis Apr: Apr 27 doi: 10.1093/cid/ciaa478 (Epub ahead of print).

7 

Whittle JS, Pavlov I, Sacchetti AD, Atwood C and Rosenberg MS: Respiratory support for adult patients with COVID-19. J Am Coll Emerg Physicians Open: Apr 2020 doi: 10.1002/emp2.12071.

8 

Shi Y, Wang Y, Shao C, Huang J, Gan J, Huang X, Bucci E, Piacentini M, Ippolito G and Melino G: COVID-19 infection: The perspectives on immune responses. Cell Death Differ. 27:1451–1454. 2020.PubMed/NCBI View Article : Google Scholar

9 

Marino A, Cosentino F, Pampaloni A, Scuderi D, Moscatt V, Gussio M, Onorante A, Zagami A, Torrisi S, Grasso S, et al: Role of tocilizumab and high flow nasal cannula in the clinical management of severe Covid-19. J Clin Trials. 10(427)2020.

10 

Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, et al: A Trial of lopinavir-ritonavir in adults hospitalized with severe covid-19. N Engl J Med. 382:1787–1799. 2020.PubMed/NCBI View Article : Google Scholar

11 

Taccone FS, Gorham J and Vincent JL: Hydroxychloroquine in the management of critically ill patients with COVID-19: The need for an evidence base. Lancet Respir Med. 8:539–541. 2020.PubMed/NCBI View Article : Google Scholar

12 

Felsenstein S, Herbert JA, McNamara PS and Hedrich CM: COVID-19: Immunology and treatment options. Clin Immunol [Internet]. 2020/04/27. 2020 Jun; 215:108448. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185015/.

13 

Cattaneo M, Bertinato EM, Birocchi S, Brizio C, Malavolta D, Manzoni M, Muscarella G and Orlandi M: Pulmonary embolism or pulmonary thrombosis in COVID-19? Is the recommendation to use high-dose heparin for thromboprophylaxis justified? Thromb Haemost. 120:1230–1232. 2020.PubMed/NCBI View Article : Google Scholar

14 

Aziz M, Aziz M, Fatima R and Assaly R: Elevated Interleukin-6 and Severe COVID-19: A meta-analysis. Med Virol: 28 April, 2020 https://doi.org/10.1002/jmv.25948.

15 

Zhang C, Wu Z, Li JW, Zhao H and Wang GQ: The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality. Int J Antimicrob Agents. 55(105954)2020.PubMed/NCBI View Article : Google Scholar

16 

Luo P, Liu Y, Qiu L, Liu X, Liu D and Li J: Tocilizumab treatment in COVID-19: A single center experience. J Med Virol: 6 April, 2020 https://doi.org/10.1002/jmv.25801.

17 

Fu B, Xu X and Wei H: Why tocilizumab could be an effective treatment for severe COVID-19? J Trans Med. 18(164)2020.PubMed/NCBI View Article : Google Scholar

18 

Nishimura M: High-flow nasal cannula oxygen therapy in adults. J Intensive Care. 3(15)2015.PubMed/NCBI View Article : Google Scholar

19 

Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, et al: High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 372:2185–2196. 2015.PubMed/NCBI View Article : Google Scholar

20 

Rochwerg B, Granton D, Wang DX, Helviz Y, Einav S, Frat JP, Mekontso-Dessap A, Schreiber A, Azoulay E, Mercat A, et al: High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: A systematic review and meta-analysis. Intensive Care Med. 45:563–572. 2019.PubMed/NCBI View Article : Google Scholar

21 

Nagata K, Morimoto T, Fujimoto D, Otoshi T, Nakagawa A, Otsuka K, Seo R, Atsumi T and Tomii K: Efficacy of high-flow nasal Cannula therapy in acute hypoxemic respiratory failure: Decreased use of mechanical ventilation. Respir Care. 60:1390–1396. 2015.PubMed/NCBI View Article : Google Scholar

22 

Koga Y, Kaneda K, Fujii N, Tanaka R, Miyauchi T, Fujita M, Hidaka K, Oda Y and Tsuruta R: Comparison of high-flow nasal cannula oxygen therapy and non-invasive ventilation as first-line therapy in respiratory failure: A multicenter retrospective study. Acute Med Surg. 7(e461)2019.PubMed/NCBI View Article : Google Scholar

23 

Wang K, Zhao W, Li J, Shu W and Duan J: The experience of high-flow nasal cannula in hospitalized patients with 2019 novel coronavirus-infected pneumonia in two hospitals of Chongqing, China. Ann Intensive Care. 10(37)2020.PubMed/NCBI View Article : Google Scholar

24 

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, et al: Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 382:1708–1720. 2020.PubMed/NCBI View Article : Google Scholar

25 

Li J, Fink JB and Ehrmann S: High-flow nasal cannula for COVID-19 patients: Low risk of bio-aerosol dispersion. Eur Respir J. 55(2000892)2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Marino A, Pampaloni A, Scuderi D, Cosentino F, Moscatt V, Ceccarelli M, Gussio M, Celesia BM, Bruno R, Borraccino S, Borraccino S, et al: High‑flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID‑19: A report of three cases and a literature review. World Acad Sci J 2: 23, 2020.
APA
Marino, A., Pampaloni, A., Scuderi, D., Cosentino, F., Moscatt, V., Ceccarelli, M. ... Cacopardo, B. (2020). High‑flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID‑19: A report of three cases and a literature review. World Academy of Sciences Journal, 2, 23. https://doi.org/10.3892/wasj.2020.64
MLA
Marino, A., Pampaloni, A., Scuderi, D., Cosentino, F., Moscatt, V., Ceccarelli, M., Gussio, M., Celesia, B. M., Bruno, R., Borraccino, S., Nunnari, G., Cacopardo, B."High‑flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID‑19: A report of three cases and a literature review". World Academy of Sciences Journal 2.6 (2020): 23.
Chicago
Marino, A., Pampaloni, A., Scuderi, D., Cosentino, F., Moscatt, V., Ceccarelli, M., Gussio, M., Celesia, B. M., Bruno, R., Borraccino, S., Nunnari, G., Cacopardo, B."High‑flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID‑19: A report of three cases and a literature review". World Academy of Sciences Journal 2, no. 6 (2020): 23. https://doi.org/10.3892/wasj.2020.64
Copy and paste a formatted citation
x
Spandidos Publications style
Marino A, Pampaloni A, Scuderi D, Cosentino F, Moscatt V, Ceccarelli M, Gussio M, Celesia BM, Bruno R, Borraccino S, Borraccino S, et al: High‑flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID‑19: A report of three cases and a literature review. World Acad Sci J 2: 23, 2020.
APA
Marino, A., Pampaloni, A., Scuderi, D., Cosentino, F., Moscatt, V., Ceccarelli, M. ... Cacopardo, B. (2020). High‑flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID‑19: A report of three cases and a literature review. World Academy of Sciences Journal, 2, 23. https://doi.org/10.3892/wasj.2020.64
MLA
Marino, A., Pampaloni, A., Scuderi, D., Cosentino, F., Moscatt, V., Ceccarelli, M., Gussio, M., Celesia, B. M., Bruno, R., Borraccino, S., Nunnari, G., Cacopardo, B."High‑flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID‑19: A report of three cases and a literature review". World Academy of Sciences Journal 2.6 (2020): 23.
Chicago
Marino, A., Pampaloni, A., Scuderi, D., Cosentino, F., Moscatt, V., Ceccarelli, M., Gussio, M., Celesia, B. M., Bruno, R., Borraccino, S., Nunnari, G., Cacopardo, B."High‑flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID‑19: A report of three cases and a literature review". World Academy of Sciences Journal 2, no. 6 (2020): 23. https://doi.org/10.3892/wasj.2020.64
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team