Open Access

Association between miR‑499 rs3746444 polymorphism and the risk of ischemic stroke: A systematic review and meta‑analysis

  • Authors:
    • Xiang-Hong Liu
    • Mei-Ling Liu
    • Rong Lin
    • Ya-Ping Xing
    • Ting-Li Zhao
    • Wen Zhang
    • Ming Zhao
    • Qing-Rong Liu
    • Kai Cao
  • View Affiliations

  • Published online on: October 6, 2020     https://doi.org/10.3892/wasj.2020.72
  • Article Number: 1
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to explore the generic association between the miR‑499 (rs3746444) polymorphism and the risk of ischemic stroke (IS). A systematic review and meta‑analysis was performed, and odds ratios (ORs) and 95% confidence intervals (CIs) were used to quantitatively estimate the association. A total of 8 studies (involving 3,400 IS cases and 3,652 controls) were included in the present meta‑analysis. The results of the allelic model (G allele vs. A allele) revealed a statistically significant association between the miR‑499 (rs3746444) polymorphism and the risk of IS; the OR was 1.16 (95% CI, 1.00‑1.34; P<0.05). Similarly, the results of the recessive model (GG vs. AG + AA), the heterozygote model (AG vs. AA) and the homozygote model (GG vs. AA) were statistically significant; the ORs were 1.36 (95% CI, 1.05‑1.77; P<0.05), 1.11 (95% CI, 1.00‑1.23; P<0.05) and 1.42 (95% CI, 1.09‑1.86; P<0.05), respectively. However, the dominant model (GG + AG vs. AA) did not exhibit any significant differences; the OR was 1.16 (95% CI, 0.99‑1.36; P>0.05). The results of the Q test indicated that the heterogeneity of the allelic model (I2=63%, P=0.01), as well as that of the dominant model (I2=60%, P=0.02), was relatively large. Subsequently, a sensitivity analysis was performed; the I2 of each model then decreased to <50%. Notably, by sensitivity analysis, both the allelic model and the dominant model exhibited a statistically significant association between the miR‑499 (rs3746444) polymorphism and the risk of IS. Egger's test did not reveal any publication bias for any of the models. On the whole, the present study demonstrates that the miR‑499 (rs3746444) polymorphism may contribute to an increased risk of IS.
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January-February 2021
Volume 3 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Liu X, Liu M, Lin R, Xing Y, Zhao T, Zhang W, Zhao M, Liu Q and Cao K: Association between miR‑499 rs3746444 polymorphism and the risk of ischemic stroke: A systematic review and meta‑analysis. World Acad Sci J 3: 1, 2021
APA
Liu, X., Liu, M., Lin, R., Xing, Y., Zhao, T., Zhang, W. ... Cao, K. (2021). Association between miR‑499 rs3746444 polymorphism and the risk of ischemic stroke: A systematic review and meta‑analysis. World Academy of Sciences Journal, 3, 1. https://doi.org/10.3892/wasj.2020.72
MLA
Liu, X., Liu, M., Lin, R., Xing, Y., Zhao, T., Zhang, W., Zhao, M., Liu, Q., Cao, K."Association between miR‑499 rs3746444 polymorphism and the risk of ischemic stroke: A systematic review and meta‑analysis". World Academy of Sciences Journal 3.1 (2021): 1.
Chicago
Liu, X., Liu, M., Lin, R., Xing, Y., Zhao, T., Zhang, W., Zhao, M., Liu, Q., Cao, K."Association between miR‑499 rs3746444 polymorphism and the risk of ischemic stroke: A systematic review and meta‑analysis". World Academy of Sciences Journal 3, no. 1 (2021): 1. https://doi.org/10.3892/wasj.2020.72