Open Access

Killip classification and baseline heart rate can be used to predict streptokinase‑induced hypotension in acute myocardial infarction

  • Authors:
    • Karniza Khalid
    • Raja Elina Ahmad
    • Sze Yee Lui
    • Ida Zaliza Zainol Abidin
  • View Affiliations

  • Published online on: May 21, 2021     https://doi.org/10.3892/wasj.2021.110
  • Article Number: 39
  • Copyright: © Khalid et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Streptokinase is the thrombolytic therapy of choice for acute myocardial infarction in hospitals without cardiac facilities. Streptokinase‑induced hypotension is one of the common adverse drug reactions and is usually observed within 30 min of an intravenous streptokinase infusion. The present study aimed to identify predictive clinical parameters for the development of hypotension in patients with acute myocardial infarction. The present retrospective study involved data transcription from National Indicator Approach (NIA) records of acute myocardial infarction recorded between 2015 to 2018. Multivariate analysis was performed to evaluate potential predictors of streptokinase‑induced hypotension and to determine the association between selected clinical variables in patients with streptokinase‑induced hypotension. The present study included a total of 412 patients with acute myocardial infarction administered streptokinase. The majority (n=258, 62.6%) did not develop any complication from the therapy, whereas 109 (26.5%) developed hypotension at 18.5 (interquartile range, 10.00) min from the initiation of therapy. Multiple logistic regression analysis revealed that with every one‑unit increment in the baseline heart rate, the risk of hypotension was reduced by 2.6%. Additionally, patients classified as Killip class III and IV were at an increased risk (5‑fold) of developing hypotension as compared with those classified as Killip I. Therefore, as demonstrated herein, these predictive factors may assist clinicians in identifying susceptible individuals and may encourage vigilance when delivering streptokinase therapy.
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Spandidos Publications style
Khalid K, Ahmad RE, Lui SY and Abidin IZ: Killip classification and baseline heart rate can be used to predict streptokinase‑induced hypotension in acute myocardial infarction. World Acad Sci J 3: 39, 2021
APA
Khalid, K., Ahmad, R.E., Lui, S.Y., & Abidin, I.Z. (2021). Killip classification and baseline heart rate can be used to predict streptokinase‑induced hypotension in acute myocardial infarction. World Academy of Sciences Journal, 3, 39. https://doi.org/10.3892/wasj.2021.110
MLA
Khalid, K., Ahmad, R. E., Lui, S. Y., Abidin, I. Z."Killip classification and baseline heart rate can be used to predict streptokinase‑induced hypotension in acute myocardial infarction". World Academy of Sciences Journal 3.4 (2021): 39.
Chicago
Khalid, K., Ahmad, R. E., Lui, S. Y., Abidin, I. Z."Killip classification and baseline heart rate can be used to predict streptokinase‑induced hypotension in acute myocardial infarction". World Academy of Sciences Journal 3, no. 4 (2021): 39. https://doi.org/10.3892/wasj.2021.110