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Use of the modified Clavien‑Dindo classification to determine the risk factors for early complications following radical gastrectomy and the effect of such complications on long‑term prognosis

  • Authors:
    • Jun Ma
    • Ying Wang
    • Shuihong Yu
    • Chaoping Zhou
    • Datian Wang
    • Daibin Tang
    • Guoqin Jiang
    • Yaming Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Department of General Surgery, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225002, P.R. China, Research and Experimental Center, Anqing Medical and Pharmaceutical College, Anqing, Anhui 246052, P.R. China, Department of Surgical Oncology, Anqing Municipal Hospital, Anqing, Anhui 246000, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 59
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    Published online on: September 24, 2021
       https://doi.org/10.3892/wasj.2021.130
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Abstract

Surgical resection remains the gold standard treatment for gastric cancer; however, the rate of post‑operative complications remains unsatisfactory. Although the majority of complications are treatable, it remains unknown whether the long‑term survival of patients is affected and what type of complications affect prognosis. In the present study, the modified Clavien‑Dindo classification system was used to examine the incidence of early complications along with the related risk factors following radical gastrectomy (RG) and to determine the effects of such complications on long‑term prognosis. For this purpose, 525 gastric cancer patients with RG were analyzed retrospectively. The results revealed that age [odds ratio (OR), 1.781; P=0.013], pre‑operative comorbidity (OR, 1.765; P=0.020), blood loss (OR, 2.153; P=0.001) and the type of surgery (OR, 3.137; P<0.001) were identified as independent risk factors associated with post‑surgery complications. Blood loss (OR, 13.053; P=0.013) and the resection type (OR, 7.936; P=0.047) were identified as independent risk factors for severe complications. The 5‑year overall survival (OS) rate of patients in the severe complication group was 35%, which was significantly worse than that of patients in the non‑severe complication group (61.8%). Severe complications (hazard ratio, 1.595; P=0.107) were not found to be independent risk factors associated with the 5‑year OS. On the whole, the present study demonstrates that complications following RG were significantly related to age, pre‑operative comorbidity, blood loss and the type of surgery. Severe complications were distinctly affected by blood loss and the resection type. The 5‑year OS of patients in the severe complication group was significantly worse than that of patients in the non‑severe complication group; however, severe complications were not found to be independent risk factors associated with long‑term survival.
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1 

Zeng H, Chen W, Zheng R, Zhang S, Ji JS, Zou X, Xia C, Sun K, Yang Z, Li H, et al: Changing cancer survival in China during 2003-15: A pooled analysis of 17 population-based cancer registries. Lancet Glob Health. 6:e555–e567. 2018.PubMed/NCBI View Article : Google Scholar

2 

Kurita N, Miyata H, Gotoh M, Shimada M, Imura S, Kimura W, Tomita N, Baba H, Kitagawa Y, Sugihara K, et al: Risk model for distal gastrectomy when treating gastric cancer on the basis of data from 33,917 Japanese patients collected using a nationwide web-based data entry system. Ann Surg. 262:295–303. 2015.PubMed/NCBI View Article : Google Scholar

3 

Clavien PA, Sanabria JR and Strasberg SM: Proposed classification of complications of surgery with examples of utility in cholecystectomy. Surgery. 111:518–526. 1992.PubMed/NCBI

4 

Dindo D, Demartines N and Clavien PA: Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 240:205–213. 2004.PubMed/NCBI View Article : Google Scholar

5 

Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, de Santibañes E, Pekolj J, Slankamenac K, Bassi C, et al: The Clavien-Dindo classification of surgical complications: Five-year experience. Ann Surg. 250:187–196. 2009.PubMed/NCBI View Article : Google Scholar

6 

Katayama H, Kurokawa Y, Nakamura K, Ito H, Kanemitsu Y, Masuda N, Tsubosa Y, Satoh T, Yokomizo A, Fukuda H, et al: Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria. Surg Today. 46:668–685. 2016.PubMed/NCBI View Article : Google Scholar

7 

Kondrup J, Allison SP, Elia M, Vellas B and Plauth M: Educational and Clinical Practice Committee, European Society of Parenteral and Enteral Nutrition (ESPEN). ESPEN guidelines for nutrition screening 2002. Clin Nutr. 22:415–421. 2003.PubMed/NCBI View Article : Google Scholar

8 

Mupparapu M and Singer SR: Editorial: The American Society of Anesthesiologists (ASA) physical status classification system and its utilization for dental patient evaluation. Quintessence Int. 49:255–256. 2018.PubMed/NCBI View Article : Google Scholar

9 

Charlson M, Szatrowski TP, Peterson J and Gold J: Validation of a combined comorbidity index. J Clin Epidemiol. 47:1245–1251. 1994.PubMed/NCBI View Article : Google Scholar

10 

Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, et al: The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017.PubMed/NCBI View Article : Google Scholar

11 

Gertsen EC, Brenkman HJ, Seesing MF, Goense L, Ruurda JP and van Hillegersberg R: Dutch Upper Gastrointestinal Cancer Audit (DUCA) group. Introduction of minimally invasive surgery for distal and total gastrectomy: A population-based study. Eur J Surg Oncol. 45:403–409. 2019.PubMed/NCBI View Article : Google Scholar

12 

Miki Y, Makuuchi R, Tokunaga M, Tanizawa Y, Bando E, Kawamura T and Terashima M: Risk factors for postoperative pneumonia after gastrectomy for gastric cancer. Surg Today. 46:552–556. 2016.PubMed/NCBI View Article : Google Scholar

13 

Chen W, Zheng R, Zeng H and Zhang S: The incidence and mortality of major cancers in China, 2012. Chin J Cancer. 35(73)2016.PubMed/NCBI View Article : Google Scholar

14 

Rei J, Lareiro S, Fernandes P, Guerra M, Miranda J and Vouga L: Uniportal video-assisted thoracic surgery anatomical resections - does previous tobacco exposure adversely influence post-operative outcomes? Rev Port Cir Cardiotorac Vasc. 26:121–125. 2019.PubMed/NCBI

15 

Ntutumu R, Liu H, Zhen L, Hu YF, Mou TY, Lin T, i BA, Yu J and Li GX: Risk factors for pulmonary complications following laparoscopic gastrectomy: A single-center study. Medicine (Baltimore). 95(e4567)2016.PubMed/NCBI View Article : Google Scholar

16 

Ramos MFKP, Pereira MA, Barchi LC, Yagi OK, Dias AR, Szor DJ, Zilberstein B, Ribeiro-Júnior U and Cecconello I: Duodenal fistula: The most lethal surgical complication in a case series of radical gastrectomy. Int J Surg. 53:366–370. 2018.PubMed/NCBI View Article : Google Scholar

17 

Filip B, Toma C, Buna-Arvinte M, Scripcariu DV and Scripcariu V: Impact of surgery and early postoperative outcomes after radical gastrectomy for cancer. Chirurgia (Bucur). 113:478–485. 2018.PubMed/NCBI View Article : Google Scholar

18 

Paik HJ, Lee SH, Choi CI, Kim DH, Jeon TY, Kim DH, Jeon UB, Choi CW and Hwang SH: Duodenal stump fistula after gastrectomy for gastric cancer: Risk factors, prevention, and management. Ann Surg Treat Res. 90:157–163. 2016.PubMed/NCBI View Article : Google Scholar

19 

Orsenigo E, Bissolati M, Socci C, Chiari D, Muffatti F, Nifosi J and Staudacher C: Duodenal stump fistula after gastric surgery for malignancies: A retrospective analysis of risk factors in a single centre experience. Gastric Cancer. 17:733–744. 2014.PubMed/NCBI View Article : Google Scholar

20 

Kim MC, Kim SY and Kim KW: Laparoscopic Reinforcement Suture (LARS) on Staple Line of Duodenal Stump Using Barbed Suture in Laparoscopic Gastrectomy for Gastric Cancer: A Prospective Single Arm Phase II Study. J Gastric Cancer. 17:354–362. 2017.PubMed/NCBI View Article : Google Scholar

21 

Wakahara T, Ueno N, Maeda T, Kanemitsu K, Yoshikawa T, Tsuchida S and Toyokawa A: Postoperative morbidity in elderly patients after gastric cancer surgery. Ann Gastroenterol. 31:621–627. 2018.PubMed/NCBI View Article : Google Scholar

22 

Ishino Y, Saigusa S, Ohi M, Yasuda H, Tanaka K, Toiyama Y, Mohri Y and Kusunoki M: Preoperative C-reactive protein and operative blood loss predict poor prognosis in patients with gastric cancer after laparoscopy-assisted gastrectomy. Asian J Endosc Surg. 7:287–294. 2014.PubMed/NCBI View Article : Google Scholar

23 

Choudhuri AH, Uppal R and Kumar M: Influence of non-surgical risk factors on anastomotic leakage after major gastrointestinal surgery: Audit from a tertiary care teaching institute. Int J Crit Illn Inj Sci. 3:246–249. 2013.PubMed/NCBI View Article : Google Scholar

24 

Lv H, Yin P, Long A, Gao Y, Zhao Z, Li J, Zhang L, Zhang L and Tang P: Clinical characteristics and risk factors of postoperative pneumonia after hip fracture surgery: A prospective cohort study. Osteoporos Int. 27:3001–3009. 2016.PubMed/NCBI View Article : Google Scholar

25 

Nelen SD, Bosscha K, Lemmens VE, Hartgrink HH, Verhoeven RH and de Wilt JH: Dutch Upper Gastrointestinal Cancer Audit group. Morbidity and mortality according to age following gastrectomy for gastric cancer. Br J Surg. 105:1163–1170. 2018.PubMed/NCBI View Article : Google Scholar

26 

Coimbra FJ, de Jesus VH, Franco CP, Calsavara VF, Ribeiro HS, Diniz AL, de Godoy AL, de Farias IC, Riechelmann RP, Begnami MD, et al: Predicting overall and major postoperative morbidity in gastric cancer patients. J Surg Oncol. 120:1371–1378. 2019.PubMed/NCBI View Article : Google Scholar

27 

Wang JB, Zheng CH, Li P, Xie JW, Lin JX, Lu J, Chen QY, Cao LL, Lin M and Huang CM: Effect of comorbidities on postoperative complications in patients with gastric cancer after laparoscopy-assisted total gastrectomy: Results from an 8-year experience at a large-scale single center. Surg Endosc. 31:2651–2660. 2017.PubMed/NCBI View Article : Google Scholar

28 

Yang SY, Roh KH, Kim YN, Cho M, Lim SH, Son T, Hyung WJ and Kim HI: Surgical outcomes after open, laparoscopic, and robotic gastrectomy for gastric cancer. Ann Surg Oncol. 24:1770–1777. 2017.PubMed/NCBI View Article : Google Scholar

29 

Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 14:101–112. 2011.PubMed/NCBI View Article : Google Scholar

30 

Li Z, Bai B, Ji G, Li J and Zhao Q: Relationship between Clavien-Dindo classification and long-term survival outcomes after curative resection for gastric cancer: A propensity score-matched analysis. Int J Surg. 60:67–73. 2018.PubMed/NCBI View Article : Google Scholar

31 

Powell A, Coxon AH, Patel N, Chan D, Christian A and Lewis W: Prognostic significance of post-operative morbidity severity score after potentially curative D2 gastrectomy for carcinoma. J Gastrointest Surg. 22:1516–1527. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ma J, Wang Y, Yu S, Zhou C, Wang D, Tang D, Jiang G and Zhang Y: Use of the modified Clavien‑Dindo classification to determine the risk factors for early complications following radical gastrectomy and the effect of such complications on long‑term prognosis. World Acad Sci J 3: 59, 2021.
APA
Ma, J., Wang, Y., Yu, S., Zhou, C., Wang, D., Tang, D. ... Zhang, Y. (2021). Use of the modified Clavien‑Dindo classification to determine the risk factors for early complications following radical gastrectomy and the effect of such complications on long‑term prognosis. World Academy of Sciences Journal, 3, 59. https://doi.org/10.3892/wasj.2021.130
MLA
Ma, J., Wang, Y., Yu, S., Zhou, C., Wang, D., Tang, D., Jiang, G., Zhang, Y."Use of the modified Clavien‑Dindo classification to determine the risk factors for early complications following radical gastrectomy and the effect of such complications on long‑term prognosis". World Academy of Sciences Journal 3.6 (2021): 59.
Chicago
Ma, J., Wang, Y., Yu, S., Zhou, C., Wang, D., Tang, D., Jiang, G., Zhang, Y."Use of the modified Clavien‑Dindo classification to determine the risk factors for early complications following radical gastrectomy and the effect of such complications on long‑term prognosis". World Academy of Sciences Journal 3, no. 6 (2021): 59. https://doi.org/10.3892/wasj.2021.130
Copy and paste a formatted citation
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Spandidos Publications style
Ma J, Wang Y, Yu S, Zhou C, Wang D, Tang D, Jiang G and Zhang Y: Use of the modified Clavien‑Dindo classification to determine the risk factors for early complications following radical gastrectomy and the effect of such complications on long‑term prognosis. World Acad Sci J 3: 59, 2021.
APA
Ma, J., Wang, Y., Yu, S., Zhou, C., Wang, D., Tang, D. ... Zhang, Y. (2021). Use of the modified Clavien‑Dindo classification to determine the risk factors for early complications following radical gastrectomy and the effect of such complications on long‑term prognosis. World Academy of Sciences Journal, 3, 59. https://doi.org/10.3892/wasj.2021.130
MLA
Ma, J., Wang, Y., Yu, S., Zhou, C., Wang, D., Tang, D., Jiang, G., Zhang, Y."Use of the modified Clavien‑Dindo classification to determine the risk factors for early complications following radical gastrectomy and the effect of such complications on long‑term prognosis". World Academy of Sciences Journal 3.6 (2021): 59.
Chicago
Ma, J., Wang, Y., Yu, S., Zhou, C., Wang, D., Tang, D., Jiang, G., Zhang, Y."Use of the modified Clavien‑Dindo classification to determine the risk factors for early complications following radical gastrectomy and the effect of such complications on long‑term prognosis". World Academy of Sciences Journal 3, no. 6 (2021): 59. https://doi.org/10.3892/wasj.2021.130
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