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Fecal calprotectin predicts complete mucosal healing in patients with ulcerative colitis: Systematic review and meta‑analysis

  • Authors:
    • Zhongsheng Cao
    • Chenglong Ye
    • Lunan Li
    • Xiaoge Geng
    • Wensheng Pan
    • Jiyong Jing
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 17
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    Published online on: January 25, 2021
       https://doi.org/10.3892/wasj.2021.88
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Abstract

Complete mucosal healing (MH) is a significant therapeutic goal for ulcerative colitis (UC). Fecal calprotectin (FC) is a promising biomarker for the assessment of the endoscopy activity of UC. However, the accuracy of FC for predicting complete MH in patients with UC has yet to be clearly demonstrated. The present study aimed to evaluate the accuracy of FC in predicting complete MH in patients with UC. A systematic search was made of the databases from 1992 to October, 2020 that evaluated MH in UC. The methodological quality of each study was assessed according to the quality assessment of diagnostic accuracy studies checklist. Colonoscopy is considered the gold standard for the assessment of mucosal inflammation. The data were pooled using a summary receiver operating characteristic curve model. The diagnostic odds ratio, sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were summarized by the random‑effects model. A total of 7 publications comprising 820 patients with UC were included in the meta‑analysis. The pooled sensitivity and specificity values for predicting complete MH in the patients with UC 0.77 (95% CI, 0.72‑0.82) and 0.80 (95% CI, 0.77‑0.83), respectively. The fecal calprotectin level had a high rule‑in value (PLR, 3.76; 95% CI, 3.07‑4.60) and a moderate rule‑out value (NLR, 0.30; 95% CI, 0.24‑0.37) for predicting complete MH in patients with UC. The results of the ROC curve analysis (area under the curve, 0.85; standard error of the mean, 0.02) and diagnostic odds ratio (13.06; 95% CI, 9.04‑18.88) also revealed discrimination for predicting complete MH in patients with UC. On the whole, the present study found that FC is a reliable non‑invasive biomarker for predicting complete MH in patients with UC.
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Copy and paste a formatted citation
Spandidos Publications style
Cao Z, Ye C, Li L, Geng X, Pan W and Jing J: Fecal calprotectin predicts complete mucosal healing in patients with ulcerative colitis: Systematic review and meta‑analysis. World Acad Sci J 3: 17, 2021.
APA
Cao, Z., Ye, C., Li, L., Geng, X., Pan, W., & Jing, J. (2021). Fecal calprotectin predicts complete mucosal healing in patients with ulcerative colitis: Systematic review and meta‑analysis. World Academy of Sciences Journal, 3, 17. https://doi.org/10.3892/wasj.2021.88
MLA
Cao, Z., Ye, C., Li, L., Geng, X., Pan, W., Jing, J."Fecal calprotectin predicts complete mucosal healing in patients with ulcerative colitis: Systematic review and meta‑analysis". World Academy of Sciences Journal 3.2 (2021): 17.
Chicago
Cao, Z., Ye, C., Li, L., Geng, X., Pan, W., Jing, J."Fecal calprotectin predicts complete mucosal healing in patients with ulcerative colitis: Systematic review and meta‑analysis". World Academy of Sciences Journal 3, no. 2 (2021): 17. https://doi.org/10.3892/wasj.2021.88
Copy and paste a formatted citation
x
Spandidos Publications style
Cao Z, Ye C, Li L, Geng X, Pan W and Jing J: Fecal calprotectin predicts complete mucosal healing in patients with ulcerative colitis: Systematic review and meta‑analysis. World Acad Sci J 3: 17, 2021.
APA
Cao, Z., Ye, C., Li, L., Geng, X., Pan, W., & Jing, J. (2021). Fecal calprotectin predicts complete mucosal healing in patients with ulcerative colitis: Systematic review and meta‑analysis. World Academy of Sciences Journal, 3, 17. https://doi.org/10.3892/wasj.2021.88
MLA
Cao, Z., Ye, C., Li, L., Geng, X., Pan, W., Jing, J."Fecal calprotectin predicts complete mucosal healing in patients with ulcerative colitis: Systematic review and meta‑analysis". World Academy of Sciences Journal 3.2 (2021): 17.
Chicago
Cao, Z., Ye, C., Li, L., Geng, X., Pan, W., Jing, J."Fecal calprotectin predicts complete mucosal healing in patients with ulcerative colitis: Systematic review and meta‑analysis". World Academy of Sciences Journal 3, no. 2 (2021): 17. https://doi.org/10.3892/wasj.2021.88
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