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Case Report Open Access

Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review

  • Authors:
    • Edoardo Campanella
    • Andrea Marino
    • Manuela Ceccarelli
    • Maria Gussio
    • Federica Cosentino
    • Vittoria Moscatt
    • Cristina Micali
    • Giuseppe Nunnari
    • Benedetto Maurizio Celesia
    • Bruno Cacopardo
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, I-98122 Messina, Italy, Department of Biomedical and Biotechnological Sciences, Unit of Infectious Diseases, University of Catania, I-95124 Catania, Italy, Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Catania, I-95124 Catania, Italy
    Copyright: © Campanella et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 14
    |
    Published online on: March 10, 2022
       https://doi.org/10.3892/wasj.2022.149
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Abstract

Patients with sickle cell disease (SCD) are more susceptible to severe coronavirus disease 2019 (COVID‑19) infection, in comparison with the general population, due to the possibility that the inflammatory state, along with hypoxia and hypercoagulability may increase the risk of developing acute SCD‑related complications. The present study reports the case of a 33‑year‑old female affected by SCD, who although vaccinated against COVID‑19, tested positive for SARS‑CoV‑2 and developed febrile pneumonia. During hospitalization, the patient complained about generalized intense pain, along with fever recurrence and increased inflammatory marker, procalcitonin and haemoglobin S levels. The patient was treated with an intravenous analgesic therapeutics cocktail in combination with red blood cell manual exchange procedure and broad‑spectrum antibiotic therapy, achieving the rapid resolution of pain and an improvement in the laboratory test results. From the case presented herein, it is thus suggested that patients with SCD and COVID‑19 infection need to be critically evaluated by clinicians, as such patients may develop severe outcomes, attributed to the overlap of two difficult to treat conditions.
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1 

Esakandari H, Nabi-Afjadi M, Fakkari-Afjadi J, Farahmandian N, Miresmaeili SM and Bahreini E: A comprehensive review of COVID-19 characteristics. Biol Proced Online. 22(19)2020.PubMed/NCBI View Article : Google Scholar

2 

Li J, Huang DQ, Zou B, Yang H, Hui WZ, Rui F, Yee NTS, Liu C, Nerurkar SN, Kai JCY, et al: Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes. J Med Virol. 93:1449–1458. 2021.PubMed/NCBI View Article : Google Scholar

3 

Kato GJ, Piel FB, Reid CD, Gaston MH, Ohene-Frempong K, Krishnamurti L, Smith WR, Panepinto JA, Weatherall DJ, Costa FF and Vichinsky EP: Sickle cell disease. Nat Rev Dis Primers. 14(18010)2018.PubMed/NCBI View Article : Google Scholar

4 

Mucalo L, Brandow AM, Dasgupta M, Mason SF, Simpson PM, Singh A, Taylor BW, Woods KJ, Yusuf FI and Panepinto JA: Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease. Blood Adv. 5:2717–2724. 2021.PubMed/NCBI View Article : Google Scholar

5 

Lee JX, Chieng WK, Lau SCD and Tan CE: COVID-19 and Hemoglobinopathies: A systematic review of clinical presentations, investigations, and outcomes. Front Med (Lausanne). 8(1848)2021.PubMed/NCBI View Article : Google Scholar

6 

Booth C, Inusa B and Obaro SK: Infection in sickle cell disease: A review. Int J Infect Dis. 14:e2–e12. 2010.PubMed/NCBI View Article : Google Scholar

7 

Hoogenboom WS, Alamuri TT, McMahon DM, Balanchivadze N, Dabak V, Mitchell WB, Morrone KB, Manwani D and Duong TQ: Clinical outcomes of COVID-19 in patients with sickle cell disease and sickle cell trait: A critical appraisal of the literature. Blood Rev: Nov 20, 2021 (Epub ahead of print).

8 

McCormack HM, Horne DJ and Sheather S: Clinical applications of visual analogue scales: A critical review. Psychol Med. 18:1007–1019. 1988.PubMed/NCBI View Article : Google Scholar

9 

Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P, Hosein Z, Padda I, Mangat J and Altaf M: Comorbidity and its impact on patients with COVID-19. SN Compr Clin Med. 2:1069–1076. 2020.PubMed/NCBI View Article : Google Scholar

10 

Alyammahi SK, Abdin SM, Alhamad DW, Elgendy SM, Altell AT and Omar HA: The dynamic association between COVID-19 and chronic disorders: An updated insight into prevalence, mechanisms and therapeutic modalities. Infect Genet Evol. 87(104647)2021.PubMed/NCBI View Article : Google Scholar

11 

Wang B, Li R, Lu Z and Huang Y: Does comorbidity increase the risk of patients with COVID-19: Evidence from meta-analysis. Aging (Albany NY). 12:6049–6057. 2020.PubMed/NCBI View Article : Google Scholar

12 

Minniti CP, Zaidi AU, Nouraie M, Manwani D, Crouch GD, Crouch AS, Callaghan MU, Carpenter S, Jacobs C, Han J, et al: Clinical predictors of poor outcomes in patients with sickle cell disease and COVID-19 infection. Blood Adv. 5:207–215. 2021.PubMed/NCBI View Article : Google Scholar

13 

Menapace LA and Thein SL: COVID-19 and sickle cell disease. Haematologica. 105:2501–2504. 2020.PubMed/NCBI View Article : Google Scholar

14 

Ceccarelli M, Marino A, Cosentino F, Moscatt V, Celesia BM, Gussio M, Bruno R, Rullo EV, Nunnari G and Cacopardo BS: Post-infectious ST elevation myocardial infarction following a COVID-19 infection: A case report. Biomed Rep. 16(10)2022.PubMed/NCBI View Article : Google Scholar

15 

Marino A, Pampaloni A, Scuderi D, Cosentino F, Moscatt V, Ceccarelli M, Gussio M, Celesia BM, Bruno R, Borraccino S, et al: High-flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID-19: A report of three cases and a literature review. World Acad Sci J. 2(23)2020.

16 

Cannas G, Merazga S and Virot E: Sickle cell disease and infections in high- and low-income countries. Mediterr J Hematol Infect Dis. 11(e2019042)2019.PubMed/NCBI View Article : Google Scholar

17 

Strouse JJ, Reller ME, Bundy DG, Amoako M, Cancio M, Han RN, Valsamakis A and Casella JF: Severe pandemic H1N1 and seasonal influenza in children and young adults with sickle cell disease. Blood. 116:3431–3434. 2010.PubMed/NCBI View Article : Google Scholar

18 

Chakravorty S, Padmore-Payne G, Ike F, Tshibangu V, Graham C, Rees D and Stuart-Smith S: COVID-19 in patients with sickle cell disease-A case series from a UK tertiary hospital. Haematologica. 105:2691–2693. 2020.PubMed/NCBI View Article : Google Scholar

19 

Brandow AM, Carroll CP, Creary S, Edwards-Elliott R, Glassberg J, Hurley RW, Kutlar A, Seisa M, Stinson J, Strouse JJ, et al: American society of hematology 2020 guidelines for sickle cell disease: Management of acute and chronic pain. Blood Adv. 4:2656–2701. 2020.PubMed/NCBI View Article : Google Scholar

20 

Russo G, De Franceschi L, Colombatti R, Rigano P, Perrotta S, Voi V, Palazzi G, Fidone C, Quota A, Graziadei G, et al: Current challenges in the management of patients with sickle cell disease-A report of the Italian experience. Orphanet J Rare Dis. 14(120)2019.PubMed/NCBI View Article : Google Scholar

21 

El-Sokkary R, Uysal S, Erdem H, Kullar R, Pekok AU, Amer F, Grgić S, Carevic B, El-Kholy A, Liskova A, et al: Profiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: An international ID-IRI survey. Eur J Clin Microbiol Infect Dis. 40:2323–2334. 2021.PubMed/NCBI View Article : Google Scholar

22 

Erdem H, Hargreaves S, Ankarali H, Caskurlu H, Ceviker SA, Bahar-Kacmaz A, Meric-Koc M, Altindis M, Yildiz-Kirazaldi Y, Kizilates F, et al: Managing adult patients with infectious diseases in emergency departments: International ID-IRI study. J Chemother. 33:302–318. 2021.PubMed/NCBI View Article : Google Scholar

23 

Marino A, Zafarana G, Ceccarelli M, Cosentino F, Moscatt V, Bruno G, Bruno R, Benanti F, Cacopardo B and Celesia BM: Immunological and clinical impact of DAA-Mediated HCV Eradication in a Cohort of HIV/HCV Coinfected Patients: Monocentric Italian Experience. Diagnostics (Basel). 11(2336)2021.PubMed/NCBI View Article : Google Scholar

24 

Celesia BM, Marino A, Borracino S, Arcadipane AF, Pantò G, Gussio M, Coniglio S, Pennisi A, Cacopardo B and Panarello G: Successful extracorporeal membrane oxygenation treatment in an acquired immune deficiency syndrome (AIDS) patient with acute respiratory distress syndrome (ARDS) complicating pneumocystis jirovecii pneumonia: A challenging case. Am J Case Rep. 21(e919570)2020.PubMed/NCBI View Article : Google Scholar

25 

Ceccarelli M, Venanzi Rullo E, Marino MA, D'Aleo F, Pellicanò GF, D'Andrea F, Marino A, Cacopardo B, Celesia BM, La Rocca G, et al: Non-AIDS defining cancers: A comprehensive update on diagnosis and management. Eur Rev Med Pharmacol Sci. 24:3849–3875. 2020.PubMed/NCBI View Article : Google Scholar

26 

Celesia BM, Marino A, Del Vecchio RF, Bruno R, Palermo F, Gussio M, Nunnari G and Cacopardo B: Is it safe and cost saving to defer the CD4+ cell count monitoring in stable patients on art with more than 350 or 500 cells/µl? Mediterr J Hematol Infect Dis. 11(e2019063)2019.PubMed/NCBI View Article : Google Scholar

27 

Marino A, Cosentino F, Ceccarelli M, Moscatt V, Pampaloni A, Scuderi D, D'Andrea F, Rullo EV, Nunnari G, Benanti F, et al: Entecavir resistance in a patient with treatment-naïve HBV: A case report. Mol Clin Oncol. 14(113)2021.PubMed/NCBI View Article : Google Scholar

28 

McGann PT and Ware RE: Hydroxyurea therapy for sickle cell anemia. Expert Opin Drug Saf. 14:1749–1758. 2015.PubMed/NCBI View Article : Google Scholar

29 

Yasara N, Premawardhena A and Mettananda S: A comprehensive review of hydroxyurea for β-haemoglobinopathies: The role revisited during COVID-19 pandemic Orphanet J Rare. Dis. 16(114)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Campanella E, Marino A, Ceccarelli M, Gussio M, Cosentino F, Moscatt V, Micali C, Nunnari G, Celesia BM, Cacopardo B, Cacopardo B, et al: Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review. World Acad Sci J 4: 14, 2022.
APA
Campanella, E., Marino, A., Ceccarelli, M., Gussio, M., Cosentino, F., Moscatt, V. ... Cacopardo, B. (2022). Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review. World Academy of Sciences Journal, 4, 14. https://doi.org/10.3892/wasj.2022.149
MLA
Campanella, E., Marino, A., Ceccarelli, M., Gussio, M., Cosentino, F., Moscatt, V., Micali, C., Nunnari, G., Celesia, B. M., Cacopardo, B."Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review". World Academy of Sciences Journal 4.2 (2022): 14.
Chicago
Campanella, E., Marino, A., Ceccarelli, M., Gussio, M., Cosentino, F., Moscatt, V., Micali, C., Nunnari, G., Celesia, B. M., Cacopardo, B."Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review". World Academy of Sciences Journal 4, no. 2 (2022): 14. https://doi.org/10.3892/wasj.2022.149
Copy and paste a formatted citation
x
Spandidos Publications style
Campanella E, Marino A, Ceccarelli M, Gussio M, Cosentino F, Moscatt V, Micali C, Nunnari G, Celesia BM, Cacopardo B, Cacopardo B, et al: Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review. World Acad Sci J 4: 14, 2022.
APA
Campanella, E., Marino, A., Ceccarelli, M., Gussio, M., Cosentino, F., Moscatt, V. ... Cacopardo, B. (2022). Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review. World Academy of Sciences Journal, 4, 14. https://doi.org/10.3892/wasj.2022.149
MLA
Campanella, E., Marino, A., Ceccarelli, M., Gussio, M., Cosentino, F., Moscatt, V., Micali, C., Nunnari, G., Celesia, B. M., Cacopardo, B."Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review". World Academy of Sciences Journal 4.2 (2022): 14.
Chicago
Campanella, E., Marino, A., Ceccarelli, M., Gussio, M., Cosentino, F., Moscatt, V., Micali, C., Nunnari, G., Celesia, B. M., Cacopardo, B."Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review". World Academy of Sciences Journal 4, no. 2 (2022): 14. https://doi.org/10.3892/wasj.2022.149
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