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Molecular detection of Coxiella burnetii infection in patients with a negative infective endocarditis culture following cardiovascular surgery

  • Authors:
    • Hung Duc Duong
    • An Thi Vinh Do
    • Ha Thi Viet Bui
    • Tam Minh Vu
  • View Affiliations / Copyright

    Affiliations: Cardiovascular Surgery Unit, Vietnam National Heart Institute, Bach Mai Hospital, Hanoi 100000, Vietnam, The Center of Hematology and Blood Transfusion, Bach Mai Hospital, Hanoi 100000, Vietnam, Department of Microbiology, VNU University of Science, Vietnam National University, Hanoi 100000, Vietnam
    Copyright: © Duong et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 33
    |
    Published online on: November 1, 2023
       https://doi.org/10.3892/wasj.2023.210
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Abstract

The present study detected Coxiella burnetii (C. burnetii) infection in patients with endocarditis with a negative bacterial culture from January, 2022 to February, 2023. For this purpose, 312 patients with endocarditis who were diagnosed and operated were included in the study after obtaining the consent of each study subject and approval from the hospital ethics committee. Following surgery, the blood samples from the patients were cultured to identify bacteria using an automatic system. In 52 cases for which the result of this culture was negative, PCR was also performed using C. burnetii primer pairs. As shown by the results, from the 52 blood samples from patients with endocarditis who were found to be negative for bacteria, 13 samples were found to be positive for C. burnetii by PCR. Among these 13 patients, all patients with a fever lasting 14 days after surgery, 6 patients with emaciation and pneumonia, and 2 patients with multi‑organ failure, who then succumbed.
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Copy and paste a formatted citation
Spandidos Publications style
Duong HD, Do AT, Bui HT and Vu TM: Molecular detection of <em>Coxiella burnetii</em> infection in patients with a negative infective endocarditis culture following cardiovascular surgery. World Acad Sci J 5: 33, 2023.
APA
Duong, H.D., Do, A.T., Bui, H.T., & Vu, T.M. (2023). Molecular detection of <em>Coxiella burnetii</em> infection in patients with a negative infective endocarditis culture following cardiovascular surgery. World Academy of Sciences Journal, 5, 33. https://doi.org/10.3892/wasj.2023.210
MLA
Duong, H. D., Do, A. T., Bui, H. T., Vu, T. M."Molecular detection of <em>Coxiella burnetii</em> infection in patients with a negative infective endocarditis culture following cardiovascular surgery". World Academy of Sciences Journal 5.6 (2023): 33.
Chicago
Duong, H. D., Do, A. T., Bui, H. T., Vu, T. M."Molecular detection of <em>Coxiella burnetii</em> infection in patients with a negative infective endocarditis culture following cardiovascular surgery". World Academy of Sciences Journal 5, no. 6 (2023): 33. https://doi.org/10.3892/wasj.2023.210
Copy and paste a formatted citation
x
Spandidos Publications style
Duong HD, Do AT, Bui HT and Vu TM: Molecular detection of <em>Coxiella burnetii</em> infection in patients with a negative infective endocarditis culture following cardiovascular surgery. World Acad Sci J 5: 33, 2023.
APA
Duong, H.D., Do, A.T., Bui, H.T., & Vu, T.M. (2023). Molecular detection of <em>Coxiella burnetii</em> infection in patients with a negative infective endocarditis culture following cardiovascular surgery. World Academy of Sciences Journal, 5, 33. https://doi.org/10.3892/wasj.2023.210
MLA
Duong, H. D., Do, A. T., Bui, H. T., Vu, T. M."Molecular detection of <em>Coxiella burnetii</em> infection in patients with a negative infective endocarditis culture following cardiovascular surgery". World Academy of Sciences Journal 5.6 (2023): 33.
Chicago
Duong, H. D., Do, A. T., Bui, H. T., Vu, T. M."Molecular detection of <em>Coxiella burnetii</em> infection in patients with a negative infective endocarditis culture following cardiovascular surgery". World Academy of Sciences Journal 5, no. 6 (2023): 33. https://doi.org/10.3892/wasj.2023.210
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