Molecular detection of Coxiella burnetii infection in patients with a negative infective endocarditis culture following cardiovascular surgery
- Hung Duc Duong
- An Thi Vinh Do
- Ha Thi Viet Bui
- Tam Minh Vu
Affiliations: Cardiovascular Surgery Unit, Vietnam National Heart Institute, Bach Mai Hospital, Hanoi 100000, Vietnam, The Center of Hematology and Blood Transfusion, Bach Mai Hospital, Hanoi 100000, Vietnam, Department of Microbiology, VNU University of Science, Vietnam National University, Hanoi 100000, Vietnam
- Published online on: November 1, 2023 https://doi.org/10.3892/wasj.2023.210
Copyright : © Duong
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License [CC BY 4.0].
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
The present study detected Coxiella burnetii (C. burnetii) infection in patients with endocarditis with a negative bacterial culture from January, 2022 to February, 2023. For this purpose, 312 patients with endocarditis who were diagnosed and operated were included in the study after obtaining the consent of each study subject and approval from the hospital ethics committee. Following surgery, the blood samples from the patients were cultured to identify bacteria using an automatic system. In 52 cases for which the result of this culture was negative, PCR was also performed using C. burnetii primer pairs. As shown by the results, from the 52 blood samples from patients with endocarditis who were found to be negative for bacteria, 13 samples were found to be positive for C. burnetii by PCR. Among these 13 patients, all patients with a fever lasting 14 days after surgery, 6 patients with emaciation and pneumonia, and 2 patients with multi‑organ failure, who then succumbed.