ABO and RhD matching in platelet transfusions: Real‑world data

Valsami,Serena; Argyrou,Aspasia; Pouliakis,Abraham; Gavalaki,Maria; Dryllis,Georgios; Grouzi,Elisavet

doi:10.3892/wasj.2023.211

ABO and RhD matching in platelet transfusions: Real‑world data

This article is part of the special Issue: Natural Products & Phytotherapeutics - Preclinical and Human Studies
Authors:
- Serena Valsami
- Aspasia Argyrou
- Abraham Pouliakis
- Maria Gavalaki
- Georgios Dryllis
- Elisavet Grouzi
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Affiliations: Hematology Laboratory‑Blood Bank, Aretaieion Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece, Blood Transfusion Department, ‘Agioi Anargyroi’ Hospital, 14564 Athens, Greece, 2nd Department of Pathology, National and Kapodistrian University of Athens, ‘Attikon’ University Hospital, 12462 Athens, Greece, Blood Transfusion Department, Laiko General Hospital, 11527 Athens, Greece, Department of Transfusion Service and Clinical Hemostasis, ‘Saint Savvas’ Oncology Hospital of Athens, 11522 Athens, Greece
Published online on: November 2, 2023 https://doi.org/10.3892/wasj.2023.211
Article Number: 34
Copyright : © Valsami et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

ABO and Rhesus D (RhD) matching in platelet transfusions varies widely worldwide, since it does not preclude good clinical responses. However, it has been shown that ABO and RhD matching selection for platelet transfusions raises efficacy and safety concerns. The present study aimed to assess and evaluate ABO and RhD matching in platelet transfusions. The present study was part of a national survey that evaluated the platelet units, and ABO and RhD blood group of patients, along with the number of platelet units produced and transfused from May to June, 2015. A total of 13,250 [12,061 random donor platelets (RDPs) and 1,189 single donor platelets (SDPs)] were evaluated. ABO identical platelets were transfused in 58.99±0.88% RDPs and 45.75±2.87% SDPs. ABO major incompatible platelets (with antigen incompatibility) were transfused in 15.92±0.66% RDPs and 24.05±2.47% SDPs. ABO minor incompatible platelets (with plasma incompatibility) were transfused in 19.70±0.71% and 22.96±2.43% RDPs and SDPs, respectively, while a combination of ABO major and minor incompatible platelets (combination of plasma and antigen incompatibility) in 5.38±0.41% and 7.23±1.51%, RDPs and SDPs respectively. A total of 6.69 and 12.29% of RhD‑positive RDPs and SDPs were transfused in RhD‑negative patients (both P<0.001). On the whole, the analysis of real‑world data indicates variations in platelet ABO and RhD matching. Further studies are required to elucidate the real impact in the management of patients, while the upcoming centralization of blood services may also be a decisive step in this direction.

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1	Dunbar NM: Does ABO and RhD matching matter for platelet transfusion? Hematology Am Soc Hematol Educ Program. 2020:512–517. 2020.PubMed/NCBI View Article : Google Scholar
2	Kaufman RM, Djulbegovic B, Gernsheimer T, Kleinman S, Tinmouth AT, Capocelli KE, Cipolle MD, Cohn CS, Fung MK, Grossman BJ, et al: Platelet transfusion: A clinical practice guideline from the AABB. Ann Intern Med. 162:205–213. 2015.PubMed/NCBI View Article : Google Scholar
3	Kumar A, Mhaskar R, Grossman BJ, Kaufman RM, Tobian AA, Kleinman S, Gernsheimer T, Tinmouth AT and Djulbegovic B: AABB Platelet Transfusion Guidelines Panel. Platelet transfusion: A systematic review of the clinical evidence. Transfusion. 55:1116–1127, 1115. 2015.PubMed/NCBI View Article : Google Scholar
4	Lee EJ and Schiffer CA: ABO compatibility can influence the results of platelet transfusion. Results of a randomized trial. Transfusion. 29:384–389. 1989.PubMed/NCBI View Article : Google Scholar
5	Dunbar NM, Katus MC, Freeman CM and Szczepiorkowski ZM: Easier said than done: ABO compatibility and D matching in apheresis platelet transfusions. Transfusion. 55:1882–1888. 2015.PubMed/NCBI View Article : Google Scholar
6	Valsami S, Pouliakis A, Gavalaki M, Argyrou A, Triantafillou E, Arvanitopoulou E, Girtovitis F, Voulgaridou V, Megalou A, Chronopoulou P, et al: Platelets transfusion in Greece: Where, when, why? A national survey. Asian J Transfus Sci. 14:158–166. 2020.PubMed/NCBI View Article : Google Scholar
7	Adamidou D, Markantonatou A, Avramidou E, Oikonomou M, Filippou A, Chroni A, Papadopoulou C, Abatzoglou E, Sidi-Frankandrea V, Kourti M, et al: Efficacy of prophylactic single donor platelets (SDP) transfusion is related to the time of storage and not to the ABO compatibility in children with malignancy. In: Proceedings of the 20th Congress of the European Hematology Association. EHA, p407, Vienna, 2015.
8	Politis C, Richardson C, Asariotou M, Grouzi EZ, E, Nomikou E, Katsarou O, Ganidou M, Martinis G, Hatzitaki M and Halkia P: Transfusion adverse events (TAEs) and errors/incorrect blood component transfused (IBCT) in Greece 2012-2017. Vox Sang. 114 (Suppl):S228–S229. 2019.
9	Quillen K: Hemolysis from platelet transfusion: Call to action for an underreported reaction. Transfusion. 52:2072–2074. 2012.PubMed/NCBI View Article : Google Scholar
10	Schiffer CA, Bohlke K, Delaney M, Hume H, Magdalinski AJ, McCullough JJ, Omel JL, Rainey JM, Rebulla P, Rowley SD, et al: Platelet transfusion for patients with cancer: American society of clinical oncology clinical practice guideline update. J Clin Oncol. 36:283–299. 2018.PubMed/NCBI View Article : Google Scholar
11	Valsami S, Dimitroulis D, Gialeraki A, Chimonidou M and Politou M: Current trends in platelet transfusions practice: The role of ABO-RhD and human leukocyte antigen incompatibility. Asian J Transfus Sci. 9:117–123. 2015.PubMed/NCBI View Article : Google Scholar
12	Lialiaris T, Digkas E, Kareli D, Pouliliou S, Asimakopoulos B, Pagonopoulou O and Simopoulou M: Distribution of ABO and Rh blood groups in Greece: An update. Int J Immunogenet. 38:1–5. 2011.PubMed/NCBI View Article : Google Scholar
13	Asllani A, Culler E and Ettkin L: A simulation-based apheresis platelet inventory management model. Transfusion. 54:2730–2735. 2014.PubMed/NCBI View Article : Google Scholar
14	Gottschall J, Wu Y, Triulzi D, Kleinman S, Strauss R, Zimrin AB, McClure C, Tan S, Bialkowski W, Murphy E, et al: The epidemiology of platelet transfusions: An analysis of platelet use at 12 US hospitals. Transfusion. 60:46–53. 2020.PubMed/NCBI View Article : Google Scholar
15	Curtis G, Scott M, Orengo L, Hendrickson JE and Tormey CA: Very low rate of anti-D development in male, primarily immunocompetent patients transfused with D-mismatched platelets. Transfusion. 58:1568–1569. 2018.PubMed/NCBI View Article : Google Scholar
16	Gunson HH, Stratton F, Cooper DG and Rawlinson VI: Primary immunization of Rh-negative volunteers. Br Med J. 1:593–595. 1970.PubMed/NCBI View Article : Google Scholar
17	Cid J and Lozano M: Risk of Rh(D) alloimmunization after transfusion of platelets from D+ donors to D-recipients. Transfusion. 45:453–454. 2005.PubMed/NCBI View Article : Google Scholar
18	Reckhaus J, Jutzi M, Fontana S, Bacher VU, Vogt M, Daslakis M and Mansouri Taleghani B: Platelet transfusion induces alloimmunization to D and non-D rhesus antigens. Transfus Med Hemother. 45:167–172. 2018.PubMed/NCBI View Article : Google Scholar
19	Baldwin ML, Ness PM, Scott D, Braine H and Kickler TS: Alloimmunization to D antigen and HLA in D-negative immunosuppressed oncology patients. Transfusion. 28:330–333. 1988.PubMed/NCBI View Article : Google Scholar
20	Goldfinger D and McGinniss MH: Rh-incompatible platelet transfusions-risks and consequences of sensitizing immunosuppressed patients. N Engl J Med. 284:942–944. 1971.PubMed/NCBI View Article : Google Scholar
21	McLeod BC, Piehl MR and Sassetti RJ: Alloimmunization to RhD by platelet transfusions in autologous bone marrow transplant recipients. Vox Sang. 59:185–189. 1990.PubMed/NCBI View Article : Google Scholar
22	Cid J, Lozano M, Ziman A, West KA, O'Brien KL, Murphy MF, Wendel S, Vázquez A, Ortín X, Hervig TA, et al: Low frequency of anti-D alloimmunization following D+ platelet transfusion: the Anti-D alloimmunization after D-incompatible platelet transfusions (ADAPT) study. Br J Haematol. 168:598–603. 2015.PubMed/NCBI View Article : Google Scholar
23	Ayache S and Herman JH: Prevention of D sensitization after mismatched transfusion of blood components: Toward optimal use of RhIG. Transfusion. 48:1990–1999. 2008.PubMed/NCBI View Article : Google Scholar
24	Poston JN, Sugalski J, Gernsheimer TB, Marc Stewart F and Pagano MB: Mitigation strategies for anti-D alloimmunization by platelet transfusion in haematopoietic stem cell transplant patients: A survey of NCCN^® centres. Vox Sang. 115:334–338. 2020.PubMed/NCBI View Article : Google Scholar
25	Solves Alcaina P: Platelet transfusion: And update on challenges and outcomes. J Blood Med. 11:19–26. 2020.PubMed/NCBI View Article : Google Scholar