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Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics (Review)

  • Authors:
    • Suhaib Al Huq Mohammed
    • Kiruba Rajamani
  • View Affiliations / Copyright

    Affiliations: Electronics and Communication Engineering, School of Engineering, Amrita Vishwa Vidyapeetham, Tiruvallur,Tamil Nadu 601103, India, Department of Biotechnology, PSGR Krishnammal College for Women, Coimbatore, Tamil Nadu 641002, India
    Copyright: © Al Huq Mohammed et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 3
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    Published online on: December 6, 2023
       https://doi.org/10.3892/wasj.2023.218
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Abstract

Protein structure is extraordinarily complex and consists of various folding processes, namely, primary, secondary, tertiary and quaternary. Currently, researchers are eager to acquire knowledge and elucidate the mechanisms involved in these processes. Over the past decade, several studies have indicated that the endoplasmic reticulum stress (ERS) response assists in the protein response via intracellular signaling. ERS plays a key role in protein folding and unfolding. An increase in ERS promotes the unwinding of the folded protein. The present review specifically discusses the protein complexity involved in dyslipidemia (the condition of elevated cholesterol levels in the blood) with the ERS response and unfolded protein response. ERS in dyslipidemia is achieved by several pathological conditions, including oxidative stress, calcium imbalance and high levels of cholesterol in the blood. Therefore, in the present review, the ERS response in dyslipidemia is specifically highlighted as regards protein complexity, which indicates that considering oxidative stress, calcium imbalance and high levels of cholesterol would be a great benefit to reducing the ERS. The present literature review was performed using the search engines of the web‑based databases (Google Scholar and ScienceDirect) with keywords such as ‘Role of chaperones in dyslipidemia’ and ‘Protein complexity’ or ‘Protein involved in dyslipidemia’. Furthermore, the role of chaperones associated with ER in finding novel therapeutics for disease prevention is also discussed.
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Spandidos Publications style
Al Huq Mohammed S and Rajamani K: Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics (Review). World Acad Sci J 6: 3, 2024.
APA
Al Huq Mohammed, S., & Rajamani, K. (2024). Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics (Review). World Academy of Sciences Journal, 6, 3. https://doi.org/10.3892/wasj.2023.218
MLA
Al Huq Mohammed, S., Rajamani, K."Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics (Review)". World Academy of Sciences Journal 6.1 (2024): 3.
Chicago
Al Huq Mohammed, S., Rajamani, K."Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics (Review)". World Academy of Sciences Journal 6, no. 1 (2024): 3. https://doi.org/10.3892/wasj.2023.218
Copy and paste a formatted citation
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Spandidos Publications style
Al Huq Mohammed S and Rajamani K: Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics (Review). World Acad Sci J 6: 3, 2024.
APA
Al Huq Mohammed, S., & Rajamani, K. (2024). Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics (Review). World Academy of Sciences Journal, 6, 3. https://doi.org/10.3892/wasj.2023.218
MLA
Al Huq Mohammed, S., Rajamani, K."Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics (Review)". World Academy of Sciences Journal 6.1 (2024): 3.
Chicago
Al Huq Mohammed, S., Rajamani, K."Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics (Review)". World Academy of Sciences Journal 6, no. 1 (2024): 3. https://doi.org/10.3892/wasj.2023.218
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