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Insight into the role of angiopoietin‑like protein 4 in podocypopathies (Review)

  • Authors:
    • Vincenzo Calabrese
    • Fortunata Zirino
    • Federica Giada Vienna
    • Rossella Siligato
    • Valeria Cernaro
    • Domenico Santoro
  • View Affiliations / Copyright

    Affiliations: Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, A.O.U. Policlinico ‘G. Martino’, University of Messina, I‑98125 Messina, Italy
    Copyright: © Calabrese et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 29
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    Published online on: April 19, 2024
       https://doi.org/10.3892/wasj.2024.244
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Abstract

Angiopoietin‑like proteins are a group of seven proteins whose structure is different from that of angiopoietins in linkage to Tie2 or Tie1 receptors. Angiopoietin‑like protein 4 (ANGPTL4), which is also known as peroxisome proliferator‑activated receptor‑γ (peroxisome proliferator‑activated receptors‑γ) angiopoietin‑related or fasting‑induced adipose factor, exists in two isoforms: Hyposialylated ANGPTL4 with a high‑isoelectric point (high‑pI), and normal sialylated ANGPTL4 with a neutral isoelectric point (neutral‑pI). The present review discusses the role of ANGPTL4 in podocypopathies. Neutral‑pI ANGPTL4 may also reduce proteinuria by binding β5 integrin and is secreted in various glomerulonephritis, while high‑pI ANGPTL4 is upregulated in minimal change disease (MCD), modifying slight diaphragm power and increasing protein loss. In experimental animal models, high‑pI ANGPTL4 is present in higher concentrations in MCD relapses than in disease remission. The administration of N‑acetylmannosamine converts high‑pI ANGPTL4 to neutral‑pI ANGPTL4 and intraperitoneal epigallocatechin‑3‑gallate reduces the glomerular expression of ANGPTL4, with a reduction in albuminuria. Glomerular ANGPTL4 upregulation appears earlier in animal models, suggesting that the dysregulation of glomerular ANGPTL4 may result in foot process damage. Serum ANGPTL4 and proteinuria are likely reduced following glucocorticoid therapy. A high pI ANGPTL4/neutral pI ANGPTL4 ratios or their ratio compared to soluble urokinase‑type plasminogen activator receptor could identify a marker for the differential diagnosis between early focal segmental glomerulosclerosis and MCD, in younger patients or in those who are not eligible for a kidney biopsy.
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1 

Kadomatsu T, Tabata M and Oike Y: Angiopoietin-like proteins: Emerging targets for treatment of obesity and related metabolic diseases. FEBS J. 278:559–564. 2011.PubMed/NCBI View Article : Google Scholar

2 

Endo M: The roles of ANGPTL families in cancer progression. J UOEH. 41:317–325. 2019.PubMed/NCBI View Article : Google Scholar

3 

Yan Q, Jiang L, Liu M, Yu D, Zhang Y, Li Y, Fang S, Li Y, Zhu YH, Yuan YF and Guan XY: ANGPTL1 interacts with integrin α1β1 to suppress HCC angiogenesis and metastasis by inhibiting JAK2/STAT3 signaling. Cancer Res. 77:5831–5845. 2017.PubMed/NCBI View Article : Google Scholar

4 

Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, et al: Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab. 10:178–188. 2009.PubMed/NCBI View Article : Google Scholar

5 

Aoi J, Endo M, Kadomatsu T, Miyata K, Ogata A, Horiguchi H, Odagiri H, Masuda T, Fukushima S, Jinnin M, et al: Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress. Mol Cancer Res. 12:239–249. 2014.PubMed/NCBI View Article : Google Scholar

6 

Aoi J, Endo M, Kadomatsu T, Miyata K, Nakano M, Horiguchi H, Ogata A, Odagiri H, Yano M, Araki K, et al: Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis. Cancer Res. 71:7502–7512. 2011.PubMed/NCBI View Article : Google Scholar

7 

Arca M, Minicocci I and Maranghi M: The angiopoietin-like protein 3: A hepatokine with expanding role in metabolism. Curr Opin Lipidol. 24:313–320. 2013.PubMed/NCBI View Article : Google Scholar

8 

Wang L, Geng T, Guo X, Liu J, Zhang P, Yang D, Li J, Yu S and Sun Y: Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer. Mol Med Rep. 11:2789–2796. 2015.PubMed/NCBI View Article : Google Scholar

9 

Marchiò S, Soster M, Cardaci S, Muratore A, Bartolini A, Barone V, Ribero D, Monti M, Bovino P, Sun J, et al: A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6. EMBO Mol Med. 4:1156–1175. 2012.PubMed/NCBI View Article : Google Scholar

10 

Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE and Spiegelman BM: Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol. 20:5343–5349. 2000.PubMed/NCBI View Article : Google Scholar

11 

Guo L, Li SY, Ji FY, Zhao YF, Zhong Y, Lv XJ, Wu XL and Qian GS: Role of Angptl4 in vascular permeability and inflammation. Inflamm Res. 63:13–22. 2014.PubMed/NCBI View Article : Google Scholar

12 

Zhu P, Goh YY, Chin HFA, Kersten S and Tan NS: Angiopoietin-like 4: A decade of research. Biosci Rep. 32:211–219. 2012.PubMed/NCBI View Article : Google Scholar

13 

Peng L, Ma J, Cui R, Chen X, Wei SY, Wei QJ and Li B: The calcineurin inhibitor tacrolimus reduces proteinuria in membranous nephropathy accompanied by a decrease in angiopoietin-like-4. PLoS One. 9(e106164)2014.PubMed/NCBI View Article : Google Scholar

14 

Chugh SS, Clement LC and Macé C: New insights into human minimal change disease: Lessons from animal models. Am J Kidney Dis. 59:284–292. 2012.PubMed/NCBI View Article : Google Scholar

15 

Clement LC, Macé C, Avila-Casado C, Joles JA, Kersten S and Chugh SS: Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome. Nat Med. 20:37–46. 2014.PubMed/NCBI View Article : Google Scholar

16 

Zhu P, Tan MJ, Huang RL, Tan CK, Chong HC, Pal M, Lam CRI, Boukamp P, Pan JY, Tan SH, et al: Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors. Cancer Cell. 19:401–415. 2011.PubMed/NCBI View Article : Google Scholar

17 

Zhang T, Niu X, Liao L, Cho EA and Yang H: The contributions of HIF-target genes to tumor growth in RCC. PLoS One. 8(e80544)2013.PubMed/NCBI View Article : Google Scholar

18 

Dong D, Jia L, Zhou Y, Ren L, Li J and Zhang J: Serum level of ANGPTL4 as a potential biomarker in renal cell carcinoma. Urol Oncol. 35:279–285. 2017.PubMed/NCBI View Article : Google Scholar

19 

Ge H, Yang G, Yu X, Pourbahrami T and Li C: Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4. J Lipid Res. 45:2071–2079. 2004.PubMed/NCBI View Article : Google Scholar

20 

Yin W, Romeo S, Chang S, Grishin NV, Hobbs HH and Cohen JC: Genetic variation in ANGPTL4 provides insights into protein processing and function. J Biol Chem. 284:13213–13222. 2009.PubMed/NCBI View Article : Google Scholar

21 

Clement LC, Avila-Casado C, Macé C, Soria E, Bakker WW, Kersten S and Chugh SS: Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med. 17:117–122. 2011.PubMed/NCBI View Article : Google Scholar

22 

La Paglia L, Listì A, Caruso S, Amodeo V, Passiglia F, Bazan V and Fanale D: Potential role of ANGPTL4 in the cross talk between metabolism and cancer through PPAR signaling pathway. PPAR Res. 2017(8187235)2017.PubMed/NCBI View Article : Google Scholar

23 

Wang Q, Oliver-Williams C, Raitakari OT, Viikari J, Lehtimäki T, Kähönen M, Järvelin MR, Salomaa V, Perola M, Danesh J, et al: Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: A drug-target Mendelian randomization analysis. Eur Heart J. 42:1160–1169. 2021.PubMed/NCBI View Article : Google Scholar

24 

Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M and Noshiro H: Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer. Oncol Lett. 11:1026–1034. 2016.PubMed/NCBI View Article : Google Scholar

25 

Vivarelli M, Massella L, Ruggiero B and Emma F: Minimal change disease. Clin J Am Soc Nephrol. 12:332–345. 2017.PubMed/NCBI View Article : Google Scholar

26 

Shalhoub RJ: Pathogenesis of lipoid nephrosis: A disorder of T-cell function. Lancet. 2:556–560. 1974.PubMed/NCBI View Article : Google Scholar

27 

Yokoyama H, Kida H, Tani Y, Abe T, Tomosugi N, Koshino Y and Hattori N: Immunodynamics of minimal change nephrotic syndrome in adults T and B lymphocyte subsets and serum immunoglobulin levels. Clin Exp Immunol. 61:601–607. 1985.PubMed/NCBI

28 

Kimata H, Fujimoto M and Furusho K: Involvement of interleukin (IL)-13, but not IL-4, in spontaneous IgE and IgG4 production in nephrotic syndrome. Eur J Immunol. 25:1497–1501. 1995.PubMed/NCBI View Article : Google Scholar

29 

Kanai T, Shiraishi H, Yamagata T, Ito T, Odaka J, Saito T, Aoyagi J and Momoi MY: Th2 cells predominate in idiopathic steroid-sensitive nephrotic syndrome. Clin Exp Nephrol. 14:578–583. 2010.PubMed/NCBI View Article : Google Scholar

30 

Nachman PH, Jennette JC and Falk R: Primary glomerular disease. In: The Kidney. Brenner BM (ed). 8th edition. Elsevier, Philadelphia, PA, pp987-1066, 2008.

31 

Pei Y, Cattran D, Delmore T, Katz A, Lang A and Rance P: Evidence suggesting under-treatment in adults with idiopathic focal segmental glomerulosclerosis. Regional glomerulonephritis registry study. Am J Med. 82:938–944. 1987.PubMed/NCBI View Article : Google Scholar

32 

Reiser J, von Gersdorff G, Loos M, Oh J, Asanuma K, Giardino L, Rastaldi MP, Calvaresi N, Watanabe H, Schwarz K, et al: Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest. 113:1390–1397. 2004.PubMed/NCBI View Article : Google Scholar

33 

Liu S and Chen J: New insight in pathogenesis of podocyte disfunction in minimal change disease. Zhejiang Da Xue Xue Bao Yi Xue Ban. 45:214–218. 2016.PubMed/NCBI View Article : Google Scholar : (In Chinese).

34 

Kaneko K, Tsuji S, Kimata T, Kitao T, Yamanouchi S and Kato S: Pathogenesis of childhood idiopathic nephrotic syndrome: A paradigm shift from T-cells to podocytes. World J Pediatr. 11:21–28. 2015.PubMed/NCBI View Article : Google Scholar

35 

Chugh SS, Macé C, Clement LC, Del Nogal Avila M and Marshall CB: Angiopoietin-like 4 based therapeutics for proteinuria and kidney disease. Front Pharmacol. 5(23)2014.PubMed/NCBI View Article : Google Scholar

36 

Li Y, Xu Z, Deng H, Liu M, Lin X, Zhang M, Li G, Yue S and Gao X: ANGPTL4 promotes nephrotic syndrome by downregulating podocyte expression of ACTN4 and podocin. Biochem Biophys Res Commun. 639:176–182. 2023.PubMed/NCBI View Article : Google Scholar

37 

McCarthy KJ and Wassenhove-McCarthy DJ: The glomerular basement membrane as a model system to study the bioactivity of heparan sulfate glycosaminoglycans. Microsc Microanal. 18:3–21. 2012.PubMed/NCBI View Article : Google Scholar

38 

Jia S, Peng X, Liang L, Zhang Y, Li M, Zhou Q, Shen X, Wang Y, Wang C, Feng S, et al: The study of Angptl4-modulated podocyte injury in IgA nephropathy. Front Physiol. 11(575722)2021.PubMed/NCBI View Article : Google Scholar

39 

Zuo Y, He Z, Chen Y and Dai L: Dual role of ANGPTL4 in inflammation. Inflamm Res. 72:1303–1313. 2023.PubMed/NCBI View Article : Google Scholar

40 

Davin JC: The glomerular permeability factors in idiopathic nephrotic syndrome. Pediatr Nephrol. 31:207–215. 2016.PubMed/NCBI View Article : Google Scholar

41 

Li Y, Gong W, Liu J, Chen X, Suo Y, Yang H and Gao X: Angiopoietin-like protein 4 promotes hyperlipidemia-induced renal injury by down-regulating the expression of ACTN4. Biochem Biophys Res Commun. 595:69–75. 2022.PubMed/NCBI View Article : Google Scholar

42 

Bertelli R, Bonanni A, Caridi G, Canepa A and Ghiggeri GM: Molecular and cellular mechanisms for proteinuria in minimal change disease. Front Med (Lausanne). 5(170)2018.PubMed/NCBI View Article : Google Scholar

43 

Li JS, Chen X, Peng L, Wei SY, Zhao SL, Diao TT, He YX, Liu F, Wei QJ, Zhang QF and Li B: Angiopoietin-like-4, a potential target of tacrolimus, predicts earlier podocyte injury in minimal change disease. PLoS One. 10(e0137049)2015.PubMed/NCBI View Article : Google Scholar

44 

Li S, Nagothu K, Ranganathan G, Ali SM, Shank B, Gokden N, Ayyadevara S, Megyesi J, Olivecrona G, Chugh SS, et al: Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury. Am J Physiol Renal Physiol. 303:F437–F448. 2012.PubMed/NCBI View Article : Google Scholar

45 

Avila-Casado Mdel C, Perez-Torres I, Auron A, Soto V, Fortoul TI and Herrera-Acosta J: Proteinuria in rats induced by serum from patients with collapsing glomerulopathy. Kidney Int. 66:133–143. 2004.PubMed/NCBI View Article : Google Scholar

46 

Shen X, Weng C, Wang Y, Wang C, Feng S, Li X, Li H, Jiang H, Wang H and Chen J: Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4. Genes Dis. 9:443–455. 2020.PubMed/NCBI View Article : Google Scholar

47 

Hayek SS, Sever S, Ko YA, Trachtman H, Awad M, Wadhwani S, Altintas MM, Wei C, Hotton AL, French AL, et al: Soluble urokinase receptor and chronic kidney disease. N Engl J Med. 373:1916–1925. 2015.PubMed/NCBI View Article : Google Scholar

48 

Schulz CA, Persson M, Christensson A, Hindy G, Almgren P, Nilsson PM, Melander O, Engström G and Orho-Melander M: Soluble urokinase-type plasminogen activator receptor (suPAR) and impaired kidney function in the population-based Malmö diet and cancer study. Kidney Int Rep. 2:239–247. 2017.PubMed/NCBI View Article : Google Scholar

49 

Siligato R, Cernaro V, Nardi C, De Gregorio F, Gembillo G, Costantino G, Conti G, Buemi M and Santoro D: Emerging therapeutic strategies for minimal change disease and focal and segmental glomerulosclerosis. Expert Opin Investig Drugs. 27:839–879. 2018.PubMed/NCBI View Article : Google Scholar

50 

Botta M, Audano M, Sahebkar A, Sirtori CR, Mitro N and Ruscica M: PPAR agonists and metabolic syndrome: An established role? Int J Mol Sci. 19(1197)2018.PubMed/NCBI View Article : Google Scholar

51 

Yang HC, Ma LJ, Ma J and Fogo AB: Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis. Kidney Int. 69:1756–1764. 2006.PubMed/NCBI View Article : Google Scholar

52 

Qiu W, Huang L, Li Y, Liu Q and Lv Y: Dysregulation of angiopoietin-like-4 associated with hyperlipidemia-induced renal injury by AMPK/ACC pathway. Curr Pharm Des. 29:300–309. 2023.PubMed/NCBI View Article : Google Scholar

53 

Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, Gonzalez FJ, Desvergne B and Wahli W: Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem. 275:28488–28493. 2000.PubMed/NCBI View Article : Google Scholar

54 

Chen S, McLean S, Carter DE and Leask A: The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts. J Cell Commun Signal. 1:175–183. 2007.PubMed/NCBI View Article : Google Scholar

55 

Lu R and Zhou J, Liu B, Liang N, He Y, Bai L, Zhang P, Zhong Y, Zhou Y and Zhou J: Paeoniflorin ameliorates adriamycin-induced nephrotic syndrome through the PPARγ/ANGPTL4 pathway in vivo and vitro. Biomed Pharmacother. 96:137–147. 2017.PubMed/NCBI View Article : Google Scholar

56 

Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, et al: Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proc Natl Acad Sci USA. 110:E3425–E3434. 2013.PubMed/NCBI View Article : Google Scholar

57 

Hu K, Babapoor-Farrokhran S, Rodrigues M, Deshpande M, Puchner B, Kashiwabuchi F, Hassan SJ, Asnaghi L, Handa JT, Merbs S, et al: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Oncotarget. 7:7816–7828. 2016.PubMed/NCBI View Article : Google Scholar

58 

Wang X, Qi D, Fu F, Li X, Liu Y, Ji K, Gao Z, Kong L, Yu C, Xie H, et al: Therapeutic and antiproteinuric effects of salvianolic acid A in combined with low-dose prednisone in minimal change disease rats: Involvement of PPARγ/Angptl4 and Nrf2/HO-1 pathways. Eur J Pharmacol. 858(172342)2019.PubMed/NCBI View Article : Google Scholar

59 

Liu G and He L: Epigallocatechin-3-gallate attenuates adriamycin-induced focal segmental glomerulosclerosis via suppression of oxidant stress and apoptosis by targeting hypoxia-inducible factor-1α/angiopoietin-like 4 pathway. Pharmacology. 103:303–314. 2019.PubMed/NCBI View Article : Google Scholar

60 

Del Nogal-Avila M, Donoro-Blazquez H, Saha MK, Marshall CB, Clement LC, Macé CE and Chugh SS: Novel therapeutic approaches for chronic kidney disease due to glomerular disorders. Am J Physiol Renal Physiol. 311:F63–F65. 2016.PubMed/NCBI View Article : Google Scholar

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Calabrese V, Zirino F, Vienna FG, Siligato R, Cernaro V and Santoro D: Insight into the role of angiopoietin‑like protein 4 in podocypopathies (Review). World Acad Sci J 6: 29, 2024.
APA
Calabrese, V., Zirino, F., Vienna, F.G., Siligato, R., Cernaro, V., & Santoro, D. (2024). Insight into the role of angiopoietin‑like protein 4 in podocypopathies (Review). World Academy of Sciences Journal, 6, 29. https://doi.org/10.3892/wasj.2024.244
MLA
Calabrese, V., Zirino, F., Vienna, F. G., Siligato, R., Cernaro, V., Santoro, D."Insight into the role of angiopoietin‑like protein 4 in podocypopathies (Review)". World Academy of Sciences Journal 6.4 (2024): 29.
Chicago
Calabrese, V., Zirino, F., Vienna, F. G., Siligato, R., Cernaro, V., Santoro, D."Insight into the role of angiopoietin‑like protein 4 in podocypopathies (Review)". World Academy of Sciences Journal 6, no. 4 (2024): 29. https://doi.org/10.3892/wasj.2024.244
Copy and paste a formatted citation
x
Spandidos Publications style
Calabrese V, Zirino F, Vienna FG, Siligato R, Cernaro V and Santoro D: Insight into the role of angiopoietin‑like protein 4 in podocypopathies (Review). World Acad Sci J 6: 29, 2024.
APA
Calabrese, V., Zirino, F., Vienna, F.G., Siligato, R., Cernaro, V., & Santoro, D. (2024). Insight into the role of angiopoietin‑like protein 4 in podocypopathies (Review). World Academy of Sciences Journal, 6, 29. https://doi.org/10.3892/wasj.2024.244
MLA
Calabrese, V., Zirino, F., Vienna, F. G., Siligato, R., Cernaro, V., Santoro, D."Insight into the role of angiopoietin‑like protein 4 in podocypopathies (Review)". World Academy of Sciences Journal 6.4 (2024): 29.
Chicago
Calabrese, V., Zirino, F., Vienna, F. G., Siligato, R., Cernaro, V., Santoro, D."Insight into the role of angiopoietin‑like protein 4 in podocypopathies (Review)". World Academy of Sciences Journal 6, no. 4 (2024): 29. https://doi.org/10.3892/wasj.2024.244
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