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Mendelian randomization study of the association between cathepsins and melanoma

  • Authors:
    • Wenwen Wang
    • Jun Li
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 47
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    Published online on: July 3, 2024
       https://doi.org/10.3892/wasj.2024.262
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Abstract

Malignant melanoma is a skin tumor with a poor prognosis. Therefore, it is critical to explore the risk factors associated with the outcome of this tumor. In the present study, Mendelian randomization (MR) was used to investigate the causal association between cathepsins and malignant melanoma. Summary statistical data on five cathepsins from European participants were extracted as exposure data. Data on melanoma from a genome‑wide association study of European ancestry were used as outcome data. Single nucleotide polymorphisms associated with cathepsins were used as instrumental variables (IVs). In a genome‑wide association study of malignant melanoma including 3,751 melanoma cases and 372,016 European ancestry controls, MR analysis was conducted to examine the effects of these IVs on melanoma. The inverse variance‑weighted method was used for MR analysis. In addition, MR‑Egger, weighted median and MR pleiotropy residual sum were used for complementary analyses. Furthermore, a series of sensitivity analyses were performed to ensure the validity and robustness of the results. The gene‑predicted results indicated no causal association between the five cathepsins and malignant melanoma (P>0.05). Cathepsin S [odds ratio (OR), 1.000; 95% confidence interval (CI), 0.999‑1.001; P=0.943], cathepsin B (OR, 1.000; 95% CI, 0.999‑1.001; P=0.763), cathepsin O (OR, 1.000; 95% CI, 0.999‑1.001; P=0.646), cathepsin E (OR, 0.999; 95% CI, 0.998‑1.001; P=0.375) and cathepsin L2 (OR, 1.101; 95% CI, 0.831‑1.458; P=0.503) were not significantly associated with the risk of developing melanoma. Sensitivity analysis demonstrated no significant bias in the aforementioned results. On the whole, in the present study, MR analysis did not provide evidence that cathepsins (cathepsin S, cathepsin B, cathepsin O, cathepsin E and cathepsin L2) are causally related to malignant melanoma.
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Spandidos Publications style
Wang W and Li J: Mendelian randomization study of the association between cathepsins and melanoma. World Acad Sci J 6: 47, 2024.
APA
Wang, W., & Li, J. (2024). Mendelian randomization study of the association between cathepsins and melanoma. World Academy of Sciences Journal, 6, 47. https://doi.org/10.3892/wasj.2024.262
MLA
Wang, W., Li, J."Mendelian randomization study of the association between cathepsins and melanoma". World Academy of Sciences Journal 6.5 (2024): 47.
Chicago
Wang, W., Li, J."Mendelian randomization study of the association between cathepsins and melanoma". World Academy of Sciences Journal 6, no. 5 (2024): 47. https://doi.org/10.3892/wasj.2024.262
Copy and paste a formatted citation
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Spandidos Publications style
Wang W and Li J: Mendelian randomization study of the association between cathepsins and melanoma. World Acad Sci J 6: 47, 2024.
APA
Wang, W., & Li, J. (2024). Mendelian randomization study of the association between cathepsins and melanoma. World Academy of Sciences Journal, 6, 47. https://doi.org/10.3892/wasj.2024.262
MLA
Wang, W., Li, J."Mendelian randomization study of the association between cathepsins and melanoma". World Academy of Sciences Journal 6.5 (2024): 47.
Chicago
Wang, W., Li, J."Mendelian randomization study of the association between cathepsins and melanoma". World Academy of Sciences Journal 6, no. 5 (2024): 47. https://doi.org/10.3892/wasj.2024.262
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