Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
World Academy of Sciences Journal
Join Editorial Board Propose a Special Issue
Print ISSN: 2632-2900 Online ISSN: 2632-2919
Journal Cover
September-October 2025 Volume 7 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-October 2025 Volume 7 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Glutathione‑S‑transferase pi‑1 polymorphisms as predictors of the severity and onset of the development of cumulative oxaliplatin‑induced neurotoxicity in patients with colorectal cancer

  • Authors:
    • Rehab A.M. Jawad
    • Bahir A. Mshimesh
    • Qasim S. Al‑Mayah
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriyah University, 98HF+2R, Baghdad, Iraq, Department of Medical Research Unit, College of Medicine, AL‑Nahrain University, 98HF+2R, Baghdad, Iraq
    Copyright: © Jawad et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 81
    |
    Published online on: June 25, 2025
       https://doi.org/10.3892/wasj.2025.369
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Colorectal cancer (CRC) is a major global health burden, and oxaliplatin is a cornerstone of its treatment. However, oxaliplatin‑induced neurotoxicity, particularly chronic cumulative neurotoxicity (CN), poses a significant clinical challenge, often severely compromising the quality of life of patients. Genetic polymorphisms in glutathione S‑transferase pi‑1 (GSTP1) may influence individual susceptibility to oxaliplatin‑induced neurotoxicity. The present study investigated the association between GSTP1 polymorphisms (rs1695 and rs1138272) and CN in patients with CRC receiving oxaliplatin‑based chemotherapy. For this purpose, a prospective observational cohort study was conducted across two oncology centers, enrolling 120 patients with CRC. GSTP1 polymorphisms were genotyped using polymerase chain reaction and Sanger sequencing. CN severity was assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events. Logistic regression analysis was used to assess the association between GSTP1 genotypes and neurotoxicity onset and severity. Significant associations were observed between GSTP1 polymorphisms and the risk of developing CN. The rs1695 GG genotype conferred a 7.7‑fold increased risk of developing CN at oxaliplatin doses <1,000 mg/m2 (P=0.012) and a 5.5‑fold risk at doses >1,000 mg/m2 (P<0.001). The rs1138272 CT genotype was found to be associated with an elevated risk of developing CN [odds ratio (OR), 4.05; P=0.004], implicating the T allele in susceptibility. The GG genotype was strongly associated with progressive CN severity, exhibiting a 5‑fold risk for grade 2 (P=0.031) and a 6.2‑fold risk for grade 3 CN (P=0.029). Similarly, the CT genotype was associated with grade 3 CN. (OR, 3.43; P=0.043). To the best of our knowledge, the present study is the first to demonstrate a link between the rs1695 and rs1138272 polymorphisms and the onset and severity of CN. On the whole, the present study demonstrates that GSTP1 polymorphisms significantly affect the oxaliplatin‑induced risk of developing CN in patients with CRC. These findings advocate genetic screening as part of personalized treatment strategies and underscore the need for further mechanistic and validation studies.
View Figures
View References

1 

Bakir WA, Ismail NH, Latif AH, Abd DW and Saied ZZ: Cytotoxicity-associated gene (CagA) producing Helicobacter pylori increased risk of developing colorectal carcinoma in Iraqi patients. Al Mustansiriyah J Pharm Sci. 14:143–149. 2014.

2 

Liu Y, Zhang C, Wang Q, Wu K, Sun Z, Tang Z and Zhang B: Temporal trends in the disease burden of colorectal cancer with its risk factors at the global and national level from 1990 to. 2019, and projections until 2044. Clin Epidemiol. 15:55–71. 2023.PubMed/NCBI View Article : Google Scholar

3 

Kobritz M, Nofi CP, Egunsola A and Zimmern AS: Financial toxicity in early-onset colorectal cancer: A national health interview survey study. Surgery. 175:1278–1284. 2024.PubMed/NCBI View Article : Google Scholar

4 

Al-Saigh THT, Abdulmawjood SA and Ahmed FA: Prognostic factor of serum carcinoembryonic antigen in colorectal cancer patients: A follow up study. Al Mustansiriyah J Pharm Sci. 21:1–6. 2022.

5 

Jawad RAM, Mshimesh BAR, Al-Mayah QS and Al-Alloosh F: A case study on complete pathological response in advanced rectal cancer patient with oxaliplatin-based chemotherapy without cumulative neurotoxicity. J Gastrointest Cancer. 56(99)2025.PubMed/NCBI View Article : Google Scholar

6 

Calls A, Torres-Espin A, Tormo M, Martínez-Escardó L, Bonet N, Casals F, Navarro X, Yuste VJ, Udina E and Bruna J: A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice. Ann Clin Transl Neurol. 9:1985–1998. 2022.PubMed/NCBI View Article : Google Scholar

7 

Cavaletti G, Alberti P and Marmiroli P: Chemotherapy-induced peripheral neurotoxicity in the era of pharmacogenomics. Lancet Oncol. 12:1151–1161. 2011.PubMed/NCBI View Article : Google Scholar

8 

Yang Y, Zhao B, Gao X, Sun J, Ye J, Li J and Cao P: Targeting strategies for oxaliplatin-induced peripheral neuropathy: Clinical syndrome, molecular basis, and drug development. J Exp Clin Cancer Res. 40(331)2021.PubMed/NCBI View Article : Google Scholar

9 

Stefansson M and Nygren P: Oxaliplatin added to fluoropyrimidine for adjuvant treatment of colorectal cancer is associated with long-term impairment of peripheral nerve sensory function and quality of life. Acta Oncol. 55:1227–1235. 2016.PubMed/NCBI View Article : Google Scholar

10 

Grothey A: Clinical management of oxaliplatin-associated neurotoxicity. Clin Colorectal Cancer. 5 (Suppl 1):S38–S46. 2005.PubMed/NCBI View Article : Google Scholar

11 

Sun X, Guo C, Huang C, Lv N, Chen H, Huang H, Zhao Y, Sun S, Zhao D, Tian J, et al: GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway. Redox Biol. 71(103116)2024.PubMed/NCBI View Article : Google Scholar

12 

Katayanagi S, Katsumata K, Mori Y, Narahara K, Shigoka M, Matsudo T, Enomoto M, Suda T, Ishizaki T, Hisada M, et al: GSTP1 as a potential predictive factor for adverse events associated with platinum-based antitumor agent-induced peripheral neuropathy. Oncol Lett. 17:2897–2904. 2019.PubMed/NCBI View Article : Google Scholar

13 

Peng Z, Wang Q, Gao J, Ji Z, Yuan J, Tian Y and Shen L: Association between GSTP1 Ile105Val polymorphism and oxaliplatin-induced neuropathy: A systematic review and meta-analysis. Cancer Chemother Pharmacol. 72:305–314. 2013.PubMed/NCBI View Article : Google Scholar

14 

Cheng F, Zhang R, Sun C, Ran Q, Zhang C, Shen C, Yao Z, Wang M, Song L and Peng C: Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: Mechanisms, pharmacokinetics and strategies. Front Pharmacol. 14(1231401)2023.PubMed/NCBI View Article : Google Scholar

15 

Attarbashee RK, Hamodat HF, Mammdoh JK and Ridha-Salman H: The possible effect of Bosentan on the methotrexate-induced salivary gland changes in male rats: Histological and Immunohistochemical study. Toxicol Res (Camb). 14(tfaf007)2025.PubMed/NCBI View Article : Google Scholar

16 

Bartolini D, Stabile AM, Migni A, Gurrado F, Lioci G, De Franco F, Mandarano M, Svegliati-Baroni G, Di Cristina M, Bellezza G, et al: Subcellular distribution and Nrf2/Keap1-interacting properties of Glutathione S-transferase P in hepatocellular carcinoma. Arch Biochem Biophys. 757(110043)2024.PubMed/NCBI View Article : Google Scholar

17 

Rapp E, Lu Z, Sun L, Serna SN, Almestica-Roberts M, Burrell KL, Nguyen ND, Deering-Rice CE and Reilly CA: Mechanisms and consequences of variable TRPA1 expression by airway epithelial cells: Effects of TRPV1 genotype and environmental agonists on cellular responses to pollutants in vitro and asthma. Environ Health Perspect. 131(27009)2023.PubMed/NCBI View Article : Google Scholar

18 

Benson AB, Venook AP, Adam M, Chang G, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming D, Garrido-Laguna I, et al: Colon cancer, version 3.2024, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 22(e240029)2024.PubMed/NCBI View Article : Google Scholar

19 

National Cancer Institute (NCI): Common Terminology Criteria for Adverse Events (CTCAE), 2025. https://ctep.cancer.gov/protocoldevelopment/electronic_applications/ctc.htm#ctc_60.

20 

Ijam AH, Mshimesh BAR, Abdulamir AS and Alsaad SF: Analysis of cytochrome P450 2C9 gene polymorphism in a sample of iraqi hypertensive patients. Med J Babylon. 21:653–658. 2024.

21 

Cowell IG, Dixon KH, Pemble SE, Ketterer B and Taylor JB: The structure of the human glutathione S-transferase pi gene. Biochem J. 255:79–83. 1988.PubMed/NCBI View Article : Google Scholar

22 

Malempati S, Agrawal N, Ravisankar D, Kothapalli VSRT, Cheemanapalli S, Tamanam RR, Govatati S and Rao PS: Role of GSTP1 functional polymorphisms in molecular pathogenesis of colorectal cancer. Hum Gene. 42(201335)2024.

23 

Marensi V, Yap MC, Ji Y, Lin C, Berthiaume LG and Leslie EM: Glutathione transferase P1 is modified by palmitate. PLoS One. 19(e0308500)2024.PubMed/NCBI View Article : Google Scholar

24 

Ben Kridis W, Toumi N and Khanfir A: Chemotherapy-induced peripheral neurotoxicity: Single-centre prospective study. BMJ Support Palliat Care. 13:e881–e884. 2024.PubMed/NCBI View Article : Google Scholar

25 

Chen YC, Tzeng CH, Chen PM, Lin JK, Lin TC, Chen WS, Jiang JK, Wang HS and Wang WS: Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinoma. Cancer Sci. 101:530–535. 2010.PubMed/NCBI View Article : Google Scholar

26 

Inada M, Sato M, Morita S, Kitagawa K, Kawada K, Mitsuma A, Sawaki M, Fujita K and Ando Y: Associations between oxaliplatin-induced peripheral neuropathy and polymorphisms of the ERCC1 and GSTP1 genes. Int J Clin Pharmacol Ther. 48:729–734. 2010.PubMed/NCBI View Article : Google Scholar

27 

Kanai M, Yoshioka A, Tanaka S, Nagayama S, Matsumoto S, Nishimura T, Niimi M, Teramukai S, Takahashi R, Mori Y, et al: Associations between glutathione S-transferase pi Ile105Val and glyoxylate aminotransferase Pro11Leu and Ile340Met polymorphisms and early-onset oxaliplatin-induced neuropathy. Cancer Epidemiol. 34:189–193. 2010.PubMed/NCBI View Article : Google Scholar

28 

Lecomte T, Landi B, Beaune P, Laurent-Puig P and Loriot MA: Glutathione S-transferase P1 polymorphism (Ile105Val) predicts cumulative neuropathy in patients receiving oxaliplatin-based chemotherapy. Clin Cancer Res. 12:3050–3056. 2006.PubMed/NCBI View Article : Google Scholar

29 

Nagai N, Okuda R, Kinoshita M and Ogata H: Decomposition kinetics of cisplatin in human biological fluids. J Pharm Pharmacol. 48:918–924. 1996.PubMed/NCBI View Article : Google Scholar

30 

Asakura T, Sasagawa A, Takeuchi H, Shibata SI, Marushima H, Mamori S and Ohkawa K: Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis. Apoptosis. 12:1269–1280. 2007.PubMed/NCBI View Article : Google Scholar

31 

Win S, Than TA and Kaplowitz N: Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death. Front Cell Dev Biol. 12(1359152)2024.PubMed/NCBI View Article : Google Scholar

32 

Shirmanova MV, Gavrina AI, Kovaleva TF, Dudenkova VV, Zelenova EE, Shcheslavskiy VI, Mozherov AM, Snopova LB, Lukyanov KA and Zagaynova EV: Insight into redox regulation of apoptosis in cancer cells with multiparametric live-cell microscopy. Sci Rep. 12(4476)2022.PubMed/NCBI View Article : Google Scholar

33 

Imbaby S, Elkholy SE, Faisal S, Abdelmaogood AKK, Mehana AE, Mansour BSA, Abd El-Moneam SM and Elaidy SM: The GSTP1/MAPKs/BIM/SMAC modulatory actions of nitazoxanide: Bioinformatics and experimental evidence in subcutaneous solid Ehrlich carcinoma-inoculated mice. Life Sci. 319(121496)2023.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Jawad RA, Mshimesh BA and Al‑Mayah QS: Glutathione‑S‑transferase pi‑1 polymorphisms as predictors of the severity and onset of the development of cumulative oxaliplatin‑induced neurotoxicity in patients with colorectal cancer. World Acad Sci J 7: 81, 2025.
APA
Jawad, R.A., Mshimesh, B.A., & Al‑Mayah, Q.S. (2025). Glutathione‑S‑transferase pi‑1 polymorphisms as predictors of the severity and onset of the development of cumulative oxaliplatin‑induced neurotoxicity in patients with colorectal cancer. World Academy of Sciences Journal, 7, 81. https://doi.org/10.3892/wasj.2025.369
MLA
Jawad, R. A., Mshimesh, B. A., Al‑Mayah, Q. S."Glutathione‑S‑transferase pi‑1 polymorphisms as predictors of the severity and onset of the development of cumulative oxaliplatin‑induced neurotoxicity in patients with colorectal cancer". World Academy of Sciences Journal 7.5 (2025): 81.
Chicago
Jawad, R. A., Mshimesh, B. A., Al‑Mayah, Q. S."Glutathione‑S‑transferase pi‑1 polymorphisms as predictors of the severity and onset of the development of cumulative oxaliplatin‑induced neurotoxicity in patients with colorectal cancer". World Academy of Sciences Journal 7, no. 5 (2025): 81. https://doi.org/10.3892/wasj.2025.369
Copy and paste a formatted citation
x
Spandidos Publications style
Jawad RA, Mshimesh BA and Al‑Mayah QS: Glutathione‑S‑transferase pi‑1 polymorphisms as predictors of the severity and onset of the development of cumulative oxaliplatin‑induced neurotoxicity in patients with colorectal cancer. World Acad Sci J 7: 81, 2025.
APA
Jawad, R.A., Mshimesh, B.A., & Al‑Mayah, Q.S. (2025). Glutathione‑S‑transferase pi‑1 polymorphisms as predictors of the severity and onset of the development of cumulative oxaliplatin‑induced neurotoxicity in patients with colorectal cancer. World Academy of Sciences Journal, 7, 81. https://doi.org/10.3892/wasj.2025.369
MLA
Jawad, R. A., Mshimesh, B. A., Al‑Mayah, Q. S."Glutathione‑S‑transferase pi‑1 polymorphisms as predictors of the severity and onset of the development of cumulative oxaliplatin‑induced neurotoxicity in patients with colorectal cancer". World Academy of Sciences Journal 7.5 (2025): 81.
Chicago
Jawad, R. A., Mshimesh, B. A., Al‑Mayah, Q. S."Glutathione‑S‑transferase pi‑1 polymorphisms as predictors of the severity and onset of the development of cumulative oxaliplatin‑induced neurotoxicity in patients with colorectal cancer". World Academy of Sciences Journal 7, no. 5 (2025): 81. https://doi.org/10.3892/wasj.2025.369
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team