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Case Report Open Access

Granulomatous mastitis co‑existing with breast cancer: A case report and mini‑review of the literature

  • Authors:
    • Abdulwahid M. Salih
    • Shaban Latif
    • Rebaz M. Ali
    • Lana R.A. Pshtiwan
    • Halkawt Omer Ali
    • Ari M. Abdullah
    • Karzan M. Salih
    • Shko H. Hassan
    • Hawkar A. Nasralla
    • Bushra O. Hussein
    • Fahmi H. Kakamad
  • View Affiliations / Copyright

    Affiliations: Department of Scientific Affairs, Smart Health Tower, Sulaymaniyah 46001, Iraq
    Copyright: © Salih et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 101
    |
    Published online on: September 4, 2025
       https://doi.org/10.3892/wasj.2025.389
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Abstract

Granulomatous mastitis (GM) is a rare inflammation of the breast marked by non‑caseating granulomatous lesions near the breast ducts and lobules. Reports of GM coinciding with breast cancer are rare. The present study describes the case of a patient with GM, high‑grade high‑grade ductal carcinoma in situ (DCIS), and invasive ductal carcinoma were present in the same breast. A 36‑year‑old woman with a 2‑week history of left breast pain was found to have a large, firm lump. A core needle biopsy led to the diagnosis of DCIS and suppurative GM. The patient was initially treated with analgesics and antibiotics for 20 days. Eventually, the patient underwent a complete mastectomy with immediate reconstruction using a TRAM flap. A subsequent histopathological examination revealed invasive ductal carcinoma of no specific type, poorly differentiated, with extensive DCIS and suppurative GM. Upon the last follow‑up, the patient was monitored and remained stable with no post‑operative complications. Furthermore, in a literature review conducted utilizing Google Scholar and PubMed, only 13 cases of the simultaneous presence of GM and breast cancer were found. The average age of these patients was 43.07±12.10 years. Of note, 7 (53.85%) of these patients had both GM and breast cancer in the left breast, while only 2 cases (15.38%) involved the conditions in contralateral breasts. In conclusion, distinguishing between breast cancer and GM is challenging. Although the simultaneous presence of GM and breast cancer is rare, it remains essential to consider this possibility. However, further research is required to clarify the association between GM and breast cancer.
View Figures

Figure 1

The breast magnetic resonance imaging
demonstrates heterogeneous non-mass-like enhancement with a small
central mass, measuring 1.82 cm, highlighted in the left
breast.

Figure 2

(A) The section shows multiple ducts,
showing ductal carcinoma in situ (black arrows) and adjacent
cystic neutrophilic granulomatous mastitis (yellow arrow), which
contains multinucleated giant cells (green arrow). (B) The section
shows (wide local excision) an area of invasive ductal carcinoma
(black arrow) with ductal carcinoma in situ (yellow
arrow).
View References

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Related Articles

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Copy and paste a formatted citation
Spandidos Publications style
Salih AM, Latif S, Ali RM, Pshtiwan LR, Ali HO, Abdullah AM, Salih KM, Hassan SH, Nasralla HA, Hussein BO, Hussein BO, et al: Granulomatous mastitis co‑existing with breast cancer: A case report and mini‑review of the literature. World Acad Sci J 7: 101, 2025.
APA
Salih, A.M., Latif, S., Ali, R.M., Pshtiwan, L.R., Ali, H.O., Abdullah, A.M. ... Kakamad, F.H. (2025). Granulomatous mastitis co‑existing with breast cancer: A case report and mini‑review of the literature. World Academy of Sciences Journal, 7, 101. https://doi.org/10.3892/wasj.2025.389
MLA
Salih, A. M., Latif, S., Ali, R. M., Pshtiwan, L. R., Ali, H. O., Abdullah, A. M., Salih, K. M., Hassan, S. H., Nasralla, H. A., Hussein, B. O., Kakamad, F. H."Granulomatous mastitis co‑existing with breast cancer: A case report and mini‑review of the literature". World Academy of Sciences Journal 7.6 (2025): 101.
Chicago
Salih, A. M., Latif, S., Ali, R. M., Pshtiwan, L. R., Ali, H. O., Abdullah, A. M., Salih, K. M., Hassan, S. H., Nasralla, H. A., Hussein, B. O., Kakamad, F. H."Granulomatous mastitis co‑existing with breast cancer: A case report and mini‑review of the literature". World Academy of Sciences Journal 7, no. 6 (2025): 101. https://doi.org/10.3892/wasj.2025.389
Copy and paste a formatted citation
x
Spandidos Publications style
Salih AM, Latif S, Ali RM, Pshtiwan LR, Ali HO, Abdullah AM, Salih KM, Hassan SH, Nasralla HA, Hussein BO, Hussein BO, et al: Granulomatous mastitis co‑existing with breast cancer: A case report and mini‑review of the literature. World Acad Sci J 7: 101, 2025.
APA
Salih, A.M., Latif, S., Ali, R.M., Pshtiwan, L.R., Ali, H.O., Abdullah, A.M. ... Kakamad, F.H. (2025). Granulomatous mastitis co‑existing with breast cancer: A case report and mini‑review of the literature. World Academy of Sciences Journal, 7, 101. https://doi.org/10.3892/wasj.2025.389
MLA
Salih, A. M., Latif, S., Ali, R. M., Pshtiwan, L. R., Ali, H. O., Abdullah, A. M., Salih, K. M., Hassan, S. H., Nasralla, H. A., Hussein, B. O., Kakamad, F. H."Granulomatous mastitis co‑existing with breast cancer: A case report and mini‑review of the literature". World Academy of Sciences Journal 7.6 (2025): 101.
Chicago
Salih, A. M., Latif, S., Ali, R. M., Pshtiwan, L. R., Ali, H. O., Abdullah, A. M., Salih, K. M., Hassan, S. H., Nasralla, H. A., Hussein, B. O., Kakamad, F. H."Granulomatous mastitis co‑existing with breast cancer: A case report and mini‑review of the literature". World Academy of Sciences Journal 7, no. 6 (2025): 101. https://doi.org/10.3892/wasj.2025.389
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