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Case Report Open Access

Enchondroma of the proximal phalanx of the foot: A case report and mini‑review of the literature

  • Authors:
    • Abdullah K. Ghafour
    • Ari M. Abdullah
    • Rezheen J. Rashid
    • Ayoob Asaad Mohammed
    • Rawa M. Ali
    • Hiwa O. Abdullah
    • Mohammed Gh. Hamasaeed
    • Hawar A. Sofi
    • Sanaa O. Karim
    • Fahmi H. Kakamad
  • View Affiliations / Copyright

    Affiliations: Department Scientific Affairs, Smart Health Tower, Sulaymaniyah 46001, Iraq, Department of Radiology, Hiwa Cancer Hospital, Sulaymaniyah 46001, Iraq, College of Medicine, University of Sulaimani, Sulaymaniyah 46001, Iraq
    Copyright: © Ghafour et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 105
    |
    Published online on: September 17, 2025
       https://doi.org/10.3892/wasj.2025.393
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Abstract

An enchondroma is a benign cartilaginous tumor of the bone. The present study describes a case of a symptomatic enchondroma in the proximal phalanx of the left second toe. A 20‑year‑old male patient presented with a painless, progressively enlarging mass on the left second toe, which had resulted in gradual deformity over the past 6 months. Over the past 2 weeks, the lump has caused him pain while wearing shoes, hindering his daily activities. An X‑ray revealed a radiolucent, eccentric lesion with loss of the medial bone cortex. Magnetic resonance imaging revealed an expansile osteolytic lesion breaching three cortices with no soft tissue involvement, consistent with an enchondroma. The surgical removal of the lesion and autologous iliac bone grafting were performed, and the histopathological analysis of the tumor revealed hypercellular sheets of chondrocytes encased by mature bone trabeculae without cortical destruction, pre‑existing lamellar bone entrapment, or soft tissue invasion. Following a 6‑month follow‑up period, the patient was in a good condition, without any recurrence or complications. In addition, the present study performed a review of 19 cases of enchondroma in different foot locations. The management of these cases included excision with bone grafting, curettage with or without grafting, total phalangectomy and amputation. There were no cases of recurrence. On the whole, in symptomatic patients with enchondroma, the surgical removal of the lesion and autologous iliac bone grafting may result in a good outcome.
View Figures

Figure 1

Pre-operative image demonstrating a
swelling at the base of the second toe of the left foot with
lateral displacement.

Figure 2

Pre-operative radiological imaging of
the bone lesion: (A) Anteroposterior plain radiograph reveals an
eccentric, expansible radiolucent lesion within the proximal
phalanx of the left second toe, with cortical bone destruction
(arrow). (B) Coronal T2-weighted image (T2WI) of the foot
illustrating an eccentric phalangeal lesion with hyperintense
signal intensity (arrow) and no associated soft tissue component.
(C) Axial post-contrast fat-suppressed T1-weighted image (T1WI)
exhibits strong enhancement with no apparent invasion of
surrounding structures.

Figure 3

Intraoperative photographs of (A) the
proximal phalanx before resection of the enchondroma, (B) after
resection of the enchondroma, (C) and the resected enchondroma.

Figure 4

Image of (A) an autologous tricortical
bone graft harvested from ipsilateral iliac bone and (B) the
inserted autologous bone graft.

Figure 5

(A) hypercellular sheets of
chondrocytes (red arrows) encased by mature bone trabeculae (blue
arrows) at the periphery without cortical destruction, entrapment
of pre-existing lamellar bone, or soft tissue invasion. (B) The
tumor has a partly lobular configuration with hypocellular and
hypercellular areas of chondrocytes (black arrows). (C) The
chondrocytes are located within lacunae (yellow arrows) lying
within a myxoid and hyaline matrix (green arrow). (D) The
chondrocytes lie within lacunae and have elongated and stellate
nuclei with fine chromatin (black arrows). There is no
multinucleation, significant pleomorphism, mitotic activity, or
necrosis. The images demonstrate hematoxylin and eosin staining.
Original magnification: (A and B) x40, (C) x100, and (D) x400.

Figure 6

Clinical image of the operated foot 6
months post-operatively.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Ghafour AK, Abdullah AM, Rashid RJ, Mohammed AA, Ali RM, Abdullah HO, Hamasaeed MG, Sofi HA, Karim SO, Kakamad FH, Kakamad FH, et al: Enchondroma of the proximal phalanx of the foot: A case report and mini‑review of the literature. World Acad Sci J 7: 105, 2025.
APA
Ghafour, A.K., Abdullah, A.M., Rashid, R.J., Mohammed, A.A., Ali, R.M., Abdullah, H.O. ... Kakamad, F.H. (2025). Enchondroma of the proximal phalanx of the foot: A case report and mini‑review of the literature. World Academy of Sciences Journal, 7, 105. https://doi.org/10.3892/wasj.2025.393
MLA
Ghafour, A. K., Abdullah, A. M., Rashid, R. J., Mohammed, A. A., Ali, R. M., Abdullah, H. O., Hamasaeed, M. G., Sofi, H. A., Karim, S. O., Kakamad, F. H."Enchondroma of the proximal phalanx of the foot: A case report and mini‑review of the literature". World Academy of Sciences Journal 7.6 (2025): 105.
Chicago
Ghafour, A. K., Abdullah, A. M., Rashid, R. J., Mohammed, A. A., Ali, R. M., Abdullah, H. O., Hamasaeed, M. G., Sofi, H. A., Karim, S. O., Kakamad, F. H."Enchondroma of the proximal phalanx of the foot: A case report and mini‑review of the literature". World Academy of Sciences Journal 7, no. 6 (2025): 105. https://doi.org/10.3892/wasj.2025.393
Copy and paste a formatted citation
x
Spandidos Publications style
Ghafour AK, Abdullah AM, Rashid RJ, Mohammed AA, Ali RM, Abdullah HO, Hamasaeed MG, Sofi HA, Karim SO, Kakamad FH, Kakamad FH, et al: Enchondroma of the proximal phalanx of the foot: A case report and mini‑review of the literature. World Acad Sci J 7: 105, 2025.
APA
Ghafour, A.K., Abdullah, A.M., Rashid, R.J., Mohammed, A.A., Ali, R.M., Abdullah, H.O. ... Kakamad, F.H. (2025). Enchondroma of the proximal phalanx of the foot: A case report and mini‑review of the literature. World Academy of Sciences Journal, 7, 105. https://doi.org/10.3892/wasj.2025.393
MLA
Ghafour, A. K., Abdullah, A. M., Rashid, R. J., Mohammed, A. A., Ali, R. M., Abdullah, H. O., Hamasaeed, M. G., Sofi, H. A., Karim, S. O., Kakamad, F. H."Enchondroma of the proximal phalanx of the foot: A case report and mini‑review of the literature". World Academy of Sciences Journal 7.6 (2025): 105.
Chicago
Ghafour, A. K., Abdullah, A. M., Rashid, R. J., Mohammed, A. A., Ali, R. M., Abdullah, H. O., Hamasaeed, M. G., Sofi, H. A., Karim, S. O., Kakamad, F. H."Enchondroma of the proximal phalanx of the foot: A case report and mini‑review of the literature". World Academy of Sciences Journal 7, no. 6 (2025): 105. https://doi.org/10.3892/wasj.2025.393
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