miR‑34a and survivin as biomarkers for oral squamous cell carcinoma surveillance in Fanconi anemia

Asal Kilic,Zisan; Yalman,Nevin; Celkan,Tiraje T.; Basaran,Bora; Yener,Haydar M.; Kumas,Omer; Gunver,Mehmet Guven

doi:10.3892/wasj.2025.422

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January-February 2026 Volume 8 Issue 1

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miR‑34a and survivin as biomarkers for oral squamous cell carcinoma surveillance in Fanconi anemia

Authors:
- Zisan Asal Kilic
- Nevin Yalman
- Tiraje T. Celkan
- Bora Basaran
- Haydar M. Yener
- Omer Kumas
- Mehmet Guven Gunver
View Affiliations / Copyright

Affiliations: Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34116, Turkey, Department of Pediatric Hematology Oncology, Yeditepe University Kosuyolu Hospital, Yeditepe University, Istanbul 34718, Turkey, Department of Pediatric Hematology Oncology, Faculty of Medicine, Istinye University, Istanbul 34396, Turkey, Department of Otorhinolaryngology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34452, Turkey, Department of Otorhinolaryngology, Cerrahpasa Faculty of Medicine, Istanbul University‑Cerrahpasa, Istanbul 34098, Turkey, Department of Otorhinolaryngology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul 34384, Turkey, Department of Biostatistics, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey

Copyright: © Asal Kilic et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 7
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Published online on: December 24, 2025

https://doi.org/10.3892/wasj.2025.422
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Abstract

Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with a poor prognosis due to late diagnosis, with a 5‑year survival rate of 35‑50%. Patients with Fanconi anemia (FA) exhibit a 500‑700‑fold increased risk of developing OSCC at younger ages. Non‑invasive biomarkers are critical for early detection in high‑risk groups. The present study investigated the salivary expression levels of miR‑34a and the serum levels of survivin, both of which are associated with the PI3K signaling pathway, in patients with OSCC (n=24), patients with FA (n=24) and healthy controls (n=40). The miRNA levels were quantified using reverse transcription‑quantitative PCR, and protein levels were measured using ELISA. Compared to the controls, the patients with OSCC exhibited significantly lower miR‑34a levels (P=0.012), and patients with FA exhibited a reduced expression of miR‑34a (P=0.014). Survivin levels were elevated in patients with OSCC (P=0.04) and FA (P=0.01) compared to the controls. A negative correlation was identified between miR‑34a and surviving levels (ρ=‑0.52, P=0.005) in patients with OSCC. These findings suggest that miR‑34a and survivin are promising non‑invasive biomarkers for assessing the risk of developing OSCC in patients with FA and OSCC. However, multicenter studies with larger cohorts are warranted to validate these results for clinical surveillance protocols.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

miR‑34a and survivin as biomarkers for oral squamous cell carcinoma surveillance in Fanconi anemia

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