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Article Open Access

Early vs. delayed ACL reconstruction: Comparative insight into functional recovery and complication profiles

  • Authors:
    • Bashir M. Rasul
    • Younus Khudhur Baeez
  • View Affiliations / Copyright

    Affiliations: Department of Adult Nursing, College of Nursing, University of Raparin, Ranya, Sulaymaniyah 46001, Iraq
    Copyright: © Rasul et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 12
    |
    Published online on: January 13, 2026
       https://doi.org/10.3892/wasj.2026.427
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Abstract

The anterior cruciate ligament (ACL) is crucial for knee stability, and its injury often necessitates surgical reconstruction. However, the optimal timing of surgery remains controversial. The present study aimed to assess the effects of surgical timing on recovery and patient outcomes. The present retrospective cohort study performed at a tertiary orthopedic center, analyzed 378 patients with ACL injuries (aged 16‑40 years) to compare the outcomes of early (≤12 weeks) vs. delayed (>12 weeks) reconstruction. Data were collected from patient records and validated questionnaires assessing function, complications and satisfaction. Statistical analyses adjusted for confounders. Ethical approval was obtained, and STROBE guidelines were followed throughout the study. As demonstrated by the results, as regards the sample of 378 patients, 108 (28.6%) patients underwent early ACL reconstruction and 270 (71.4%) delayed ACL reconstruction. Males were predominant (94.2%), with a median age of 29 years. Sports injuries caused 74.9% of ACL tears. Pre‑operative rehabilitation was more common in delayed cases (33.3 vs. 22.2%, P=0.035). Excellent Lysholm scores were achieved by 88 (81.5%) patients who underwent early ACL reconstruction vs. 112 (41.5%) patients who underwent delayed ACL reconstruction (P<0.001). Knee stiffness (8.5 vs. 1.9%), pain (18.1 vs. 5.6%) and instability (8.1 vs. 1.9%) were significantly higher in the patients who underwent delayed ACL reconstruction. Post‑operative rehabilitation was near‑universal (96.8%). Re‑tear and infection rates did not exhibit significant differences between the two groups. On the whole, the present study demonstrates that early ACL reconstruction (performed within 12 weeks of injury) leads to improved function, higher activity levels and fewer complications than delayed surgery. Despite longer pre‑operative rehabilitation in the cases undergoing delayed ACL reconstruction, early intervention is recommended, particularly for younger, active patients, with individualized decision‑making advised.

View Figures

Figure 1

Flow chart illustrating the process of
patient inclusion and participation in the present study. ACL,
anterior cruciate ligament; ACLR, anterior cruciate ligament
reconstruction.
View References

1 

Kaeding CC, Léger-St-Jean B and Magnussen RA: Epidemiology and diagnosis of anterior cruciate ligament injuries. Clin Sports Med. 36:1–8. 2017.PubMed/NCBI View Article : Google Scholar

2 

Shen X, Liu T, Xu S, Chen B, Tang X, Xiao J and Qin Y: Optimal timing of anterior cruciate ligament reconstruction in patients with anterior cruciate ligament tear: A systematic review and meta-analysis. JAMA Netw Open. 5(e2242742)2022.PubMed/NCBI View Article : Google Scholar

3 

Waldron K, Brown M, Calderon A and Feldman M: Anterior cruciate ligament rehabilitation and return to sport: How fast is too fast? Arthrosc Sports Med Rehabil. 4:e175–e179. 2022.PubMed/NCBI View Article : Google Scholar

4 

Herbst E, Hoser C, Gföller P, Hepperger C, Abermann E, Neumayer K, Musahl V and Fink C: Impact of surgical timing on the outcome of anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 25:569–577. 2017.PubMed/NCBI View Article : Google Scholar

5 

Anstey DE, Heyworth BE, Price MD and Gill TJ: Effect of timing of ACL reconstruction in surgery and development of meniscal and chondral lesions. Phys Sportsmed. 40:36–40. 2012.PubMed/NCBI View Article : Google Scholar

6 

Högberg J, Fridh E, Piussi R, Senorski RH, Cristiani R, Samuelsson K, Thomeé R and Senorski EH: Delayed anterior cruciate ligament reconstruction is associated with lower odds of returning to preinjury physical activity level at 12 months Follow-Up. Arthroscopy. 41:3401–3412.e4. 2025.PubMed/NCBI View Article : Google Scholar

7 

Thomas AC, Wojtys EM, Brandon C and Palmieri-Smith RM: Muscle atrophy contributes to quadriceps weakness after anterior cruciate ligament reconstruction. J Sci Med Sport. 19:7–11. 2016.PubMed/NCBI View Article : Google Scholar

8 

Briggs KK, Kocher MS, Rodkey WG and Steadman JR: Reliability, validity, and responsiveness of the Lysholm knee score and Tegner activity scale for patients with meniscal injury of the knee. J Bone Joint Surg Am. 88:698–705. 2006.PubMed/NCBI View Article : Google Scholar

9 

Scuderi GR, Bourne RB, Noble PC, Benjamin JB, Lonner JH and Scott W: The new knee society knee scoring system. Clin Orthop Relat Res. 470:3–19. 2011.

10 

Migliorini F, Lucenti L, Mok YR, Bardazzi T, D Ambrosi R, De Carli A, Paolicelli D and Maffulli N: Anterior cruciate ligament reconstruction using lateral Extra-articular procedures: A systematic review. Medicina (Kaunas). 61(294)2025.PubMed/NCBI View Article : Google Scholar

11 

Patra SK, Unnava N, Patro BP and Mohanty S: Timing of anterior cruciate ligament reconstruction and its effect on associated chondral damage and meniscal injury: A prospective observational study. Int J Res Orthop. 9:770–775. 2023.

12 

Joseph AM, Collins CL, Henke NM, Yard EE, Fields SK and Comstock RD: A multisport epidemiologic comparison of anterior cruciate ligament injuries in high school athletics. J Athl Train. 48:810–817. 2013.PubMed/NCBI View Article : Google Scholar

13 

Montalvo AM, Schneider DK, Webster KE, Yut L, Galloway MT, Heidt RS Jr, Kaeding CC, Kremcheck TE, Magnussen RA, Parikh SN and Stanfield DT: Anterior cruciate ligament injury risk in sport: A systematic review and meta-analysis of injury incidence by sex and sport classification. J Athl Train. 54:472–482. 2019.PubMed/NCBI View Article : Google Scholar

14 

Widhalm HK, Draschl A, Horns J, Rilk S, Leitgeb J, Hajdu S and Sadoghi P: The optimal window for reconstruction of the anterior cruciate ligament (ACL) with respect to quadriceps atrophies lies within 21 to 100 days. PLoS One. 19(e0296943)2024.PubMed/NCBI View Article : Google Scholar

15 

Zakharia A, Zhang K, Al-Katanani F, Rathod P, Uddandam A, Kay J, Murphy B, Ogborn D and de SAD: Prehabilitation prior to anterior cruciate ligament reconstruction is a safe and effective intervention for short-to long-term benefits: A systematic review. Knee Surg Sports Traumatol Arthrosc. 33:4148–4166. 2025.PubMed/NCBI View Article : Google Scholar

16 

Ricupito R, Grassi A, Mourad F, Di Filippo L, Gobbo M and Maselli F: Anterior Cruciate Ligament Return to Play:‘A Framework for Decision Making’. J Clin Med. 14(2146)2025.PubMed/NCBI View Article : Google Scholar

17 

Liu AF, Guo TC, Feng HC, Yu WJ, Chen JX and Zhai JB: Efficacy and safety of early versus delayed reconstruction for anterior cruciate ligament injuries: A systematic review and meta-analysis. Knee. 44:43–58. 2023.PubMed/NCBI View Article : Google Scholar

18 

Zsidai B, Kaarre J, Narup E and Samuelsson K: Timing of anterior cruciate ligament surgery. Clin Sports Med. 43:331–341. 2024.PubMed/NCBI View Article : Google Scholar

19 

Battaglia M, Arner JW, Midtgaard KS, Haber DB, Peebles LA, Peebles AM, Ganokroj P, Whalen RJ, Provencher MT, Torre G and Ciatti R: Early versus standard return to play following ACL reconstruction: Impact on volume of play and career longevity in 180 professional European soccer players: A retrospective cohort study. J Orthop Traumatol. 26(29)2025.PubMed/NCBI View Article : Google Scholar

20 

Piussi R, Simonson R, Zsidai B, Grassi A, Karlsson J, Della Villa F, Samuelsson K and Senorski EH: Better safe than sorry? A systematic review with meta-analysis on time to return to sport after ACL reconstruction as a risk factor for second ACL injury. J Orthop Sports Phys Ther. 54:161–175. 2024.PubMed/NCBI View Article : Google Scholar

21 

Lee YS, Lee OS, Lee SH and Hui TS: Effect of the timing of anterior cruciate ligament reconstruction on clinical and stability outcomes: A systematic review and Meta-analysis. Arthroscopy. 34:592–602. 2018.PubMed/NCBI View Article : Google Scholar

22 

Cassano GD, Moretti L, Vicenti G, Buono C, Albano F, Ladogana T, Rausa I, Notarnicola A and Solarino G: Infection after anterior cruciate ligament reconstruction: A narrative review of the literature. Healthcare (Basel). 12(894)2024.PubMed/NCBI View Article : Google Scholar

23 

Phillips T, Ronna B, Terner Z, Cushing T, Goldenberg N and Shybut T: After 40 days intra-articular injury, risk profile increases linearly with time to surgery in adolescent patients undergoing primary anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 33:1192–1201. 2025.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Rasul BM and Baeez YK: <p>Early vs. delayed ACL reconstruction: Comparative insight into functional recovery and complication profiles</p>. World Acad Sci J 8: 12, 2026.
APA
Rasul, B.M., & Baeez, Y.K. (2026). <p>Early vs. delayed ACL reconstruction: Comparative insight into functional recovery and complication profiles</p>. World Academy of Sciences Journal, 8, 12. https://doi.org/10.3892/wasj.2026.427
MLA
Rasul, B. M., Baeez, Y. K."<p>Early vs. delayed ACL reconstruction: Comparative insight into functional recovery and complication profiles</p>". World Academy of Sciences Journal 8.1 (2026): 12.
Chicago
Rasul, B. M., Baeez, Y. K."<p>Early vs. delayed ACL reconstruction: Comparative insight into functional recovery and complication profiles</p>". World Academy of Sciences Journal 8, no. 1 (2026): 12. https://doi.org/10.3892/wasj.2026.427
Copy and paste a formatted citation
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Spandidos Publications style
Rasul BM and Baeez YK: <p>Early vs. delayed ACL reconstruction: Comparative insight into functional recovery and complication profiles</p>. World Acad Sci J 8: 12, 2026.
APA
Rasul, B.M., & Baeez, Y.K. (2026). <p>Early vs. delayed ACL reconstruction: Comparative insight into functional recovery and complication profiles</p>. World Academy of Sciences Journal, 8, 12. https://doi.org/10.3892/wasj.2026.427
MLA
Rasul, B. M., Baeez, Y. K."<p>Early vs. delayed ACL reconstruction: Comparative insight into functional recovery and complication profiles</p>". World Academy of Sciences Journal 8.1 (2026): 12.
Chicago
Rasul, B. M., Baeez, Y. K."<p>Early vs. delayed ACL reconstruction: Comparative insight into functional recovery and complication profiles</p>". World Academy of Sciences Journal 8, no. 1 (2026): 12. https://doi.org/10.3892/wasj.2026.427
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