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Article Open Access

Management of cholecysto‑choledocholithiasis by laparoendoscopic rendezvous: A single‑center series of 80 patients

  • Authors:
    • Levan Koiava
    • Oleg Koiava
    • David Abuladze
    • Leeroy Musiyarira
    • Salome Gavasheli
    • Ivane Abiatari
  • View Affiliations / Copyright

    Affiliations: Institute of Medical and Public Health Research, Ilia State University, 0179 Tbilisi, Georgia, Department of Endoscopy, Department of Bariatric and General Surgery, Innova Medical Center, 0186 Tbilisi, Georgia
    Copyright: © Koiava et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 16
    |
    Published online on: January 22, 2026
       https://doi.org/10.3892/wasj.2026.431
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Abstract

Laparoendoscopic rendezvous (LERV) is a single‑stage technique increasingly used for the treatment of cholecysto‑choledocholithiasis, aiming to reduce morbidity compared to conventional two‑stage approaches. The present study aimed to assess the safety, efficacy and specific clinical characteristics of LERV. For this purpose, 80 patients undergoing LERV between May, 2018 and February, 2025 were retrospectively analyzed. The technique included laparoscopic cystic duct cannulation, antegrade guidewire passage, endoscopic sphincterotomy and laparoscopic cholecystectomy. Primary outcomes were common bile duct clearance, morbidity and mortality. The LERV procedure was successfully implemented in 79 of 80 patients (98.7%), with no open conversions. The initial success rate was achieved in 97.5%. The median operative time was 115 min, and the median hospital stay was 3 days. Post‑operative complications occurred in 8.8% of patients, predominantly mild; no mortality was recorded. Post‑procedural pancreatitis occurred in 6.3% of patients. LERV was effective in complex cases, including pediatric patients (6.3%), post‑bariatric surgery (7.5%) and periampullary diverticulum (3.8%). In the whole, the present study demonstrates that LERV is a safe and effective single‑stage approach for the management of cholecysto‑choledocholithiasis, with particular advantages in anatomically or technically challenging cases. Its application, despite requiring coordinated multidisciplinary expertise, is increasingly supported by growing evidence.

View Figures

Figure 1

Operative time (duration of LERV)
stratified by intervention type (elective vs. urgent).
Box-and-whisker plots illustrate the distribution of operative
times for each group. The box represents the interquartile range,
and the line inside the box indicates the median. Whiskers extend
to the minimum and maximum values. The median operative time was
110 min (range, 55-180 min) for elective cases (n=44) and 120 min
(range, 55-310 min) for urgent cases (n=36). Differences between
the groups (elective vs. urgent) were assessed using the
Mann-Whitney U test (P=0.139). LERV, laparoendoscopic
rendezvous.
View References

1 

Gallaher JR and Charles A: Acute cholecystitis: A review. JAMA. 327:965–975. 2022.PubMed/NCBI View Article : Google Scholar

2 

Ding YB, Deng B, Liu XN, Wu J, Xiao WM, Wang YZ, Ma JM, Li Q and Ju ZS: Synchronous vs sequential laparoscopic cholecystectomy for cholecystocholedocholithiasis. World J Gastroenterol. 19:2080–2086. 2013.PubMed/NCBI View Article : Google Scholar

3 

Salman B, Yilmaz U, Kerem M, Bedirli A, Sare M, Sakrak O and Tatlicioglu E: The timing of laparoscopic cholecystectomy after endoscopic retrograde cholangiopancreaticography in cholelithiasis coexisting with choledocholithiasis. J Hepatobiliary Pancreat Surg. 16:832–836. 2009.PubMed/NCBI View Article : Google Scholar

4 

Manes G, Paspatis G, Aabakken L, Anderloni A, Arvanitakis M, Ah-Soune P, Barthet M, Domagk D, Dumonceau JM, Gigot JF, et al: Endoscopic management of common bile duct stones: European society of gastrointestinal endoscopy (ESGE) guideline. Endoscopy. 51:472–491. 2019.PubMed/NCBI View Article : Google Scholar

5 

Csendes A, Burdiles P, Diaz JC, Maluenda F, Korn O, Vallejo E and Csendes P: Prevalence of common bile duct stones according to the increasing number of risk factors present. A prospective study employing routinely intraoperative cholangiography in 477 cases. Hepatogastroenterology. 45:1415–1421. 1998.PubMed/NCBI

6 

McNicoll CF, Pastorino A, Farooq U, Froehlich MJ and St Hill CR: Choledocholithiasis. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island, FL, 2025.

7 

Wilkins T, Agabin E, Varghese J and Talukder A: Gallbladder dysfunction: Cholecystitis, choledocholithiasis, cholangitis, and biliary dyskinesia. Prim Care. 44:575–597. 2017.PubMed/NCBI View Article : Google Scholar

8 

Schiphorst AH, Besselink MG, Boerma D, Timmer R, Wiezer MJ, van Erpecum KJ, Broeders IA and van Ramshorst B: Timing of cholecystectomy after endoscopic sphincterotomy for common bile duct stones. Surg Endosc. 22:2046–2050. 2008.PubMed/NCBI View Article : Google Scholar

9 

Li VKM, Yum JLK and Yeung YP: Optimal timing of elective laparoscopic cholecystectomy after acute cholangitis and subsequent clearance of choledocholithiasis. Am J Surg. 200:483–488. 2010.PubMed/NCBI View Article : Google Scholar

10 

Reinders JS, Gouma DJ, Heisterkamp J, Tromp E, van Ramshorst B and Boerma D: Laparoscopic cholecystectomy is more difficult after a previous endoscopic retrograde cholangiography. HPB (Oxford). 15:230–234. 2013.PubMed/NCBI View Article : Google Scholar

11 

Kostro J, Marek I, Pęksa R, Łaski D, Hellmann AR, Kobiela J, Hać S, Pieńkowska J, Adrych K and Śledziński Z: Cholecystectomy after endoscopic retrograde cholangiopancreatography-effect of time on treatment outcomes. Prz Gastroenterol. 13:251–257. 2018.PubMed/NCBI View Article : Google Scholar

12 

Pekgoz M: Post-endoscopic retrograde cholangiopancreatography pancreatitis: A systematic review for prevention and treatment. World J Gastroenterol. 25:4019–4042. 2019.PubMed/NCBI View Article : Google Scholar

13 

Akshintala VS, Kanthasamy K, Bhullar FA, Sperna Weiland CJ, Kamal A, Kochar B, Gurakar M, Ngamruengphong S, Kumbhari V, Brewer-Gutierrez OI, et al: Incidence, severity, and mortality of post-ERCP pancreatitis: An updated systematic review and meta-analysis of 145 randomized controlled trials. Gastrointest Endosc. 98:1–6.e12. 2023.PubMed/NCBI View Article : Google Scholar

14 

Barkin JS, Casal GL, Reiner DK, Goldberg RI, Phillips RS and Kaplan S: A comparative study of contrast agents for endoscopic retrograde pancreatography. Am J Gastroenterol. 86:1437–1441. 1991.PubMed/NCBI

15 

Kochar B, Akshintala VS, Afghani E, Elmunzer BJ, Kim KJ, Lennon AM, Khashab MA, Kalloo AN and Singh VK: Incidence, severity, and mortality of post-ERCP pancreatitis: A systematic review by using randomized, controlled trials. Gastrointest Endosc. 81:143–149.e9. 2015.PubMed/NCBI View Article : Google Scholar

16 

Enochsson L, Swahn F, Arnelo U, Nilsson M, Löhr M and Persson G: Nationwide, population-based data from 11,074 ERCP procedures from the Swedish registry for gallstone surgery and ERCP. Gastrointest Endosc. 72:1175–1184.e1-e3. 2010.PubMed/NCBI View Article : Google Scholar

17 

Deslandres E, Gagner M, Pomp A, Rheault M, Leduc R, Clermont R, Gratton J and Bernard EJ: Intraoperative endoscopic sphincterotomy for common bile duct stones during laparoscopic cholecystectomy. Gastrointest Endosc. 39:54–58. 1993.PubMed/NCBI View Article : Google Scholar

18 

Lin Y, Su Y, Yan J and Li X: Laparoendoscopic rendezvous versus ERCP followed by laparoscopic cholecystectomy in the management of cholecystocholedocholithiasis: A systemic review and meta-analysis. Surg Endosc. 34:4214–4224. 2020.PubMed/NCBI View Article : Google Scholar

19 

Zang JF, Zhang C and Gao JY: Endoscopic retrograde cholangiopancreatography and laparoscopic cholecystectomy during the same session: Feasibility and safety. World J Gastroenterol. 19:6093–6097. 2013.PubMed/NCBI View Article : Google Scholar

20 

La Barba G, Gardini A, Cavargini E, Casadei A, Morgagni P, Bazzocchi F, D'Acapito F, Cavaliere D, Curti R, Tringali D, et al: Laparoendoscopic rendezvous in the treatment of cholecysto-choledocholitiasis: A single series of 200 patients. Surg Endosc. 32:3868–3873. 2018.PubMed/NCBI View Article : Google Scholar

21 

Dindo D, Demartines N and Clavien PA: Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 240:205–213. 2004.PubMed/NCBI View Article : Google Scholar

22 

Qian Y, Xie J, Jiang P, Yin Y and Sun Q: Laparoendoscopic rendezvous versus ERCP followed by laparoscopic cholecystectomy for the management of cholecysto-choledocholithiasis: A retrospectively cohort study. Surg Endosc. 34:2483–2489. 2020.PubMed/NCBI View Article : Google Scholar

23 

Voermans RP, Eisendrath P, Bruno MJ, Le Moine O, Devière J and Fockens P: ARCADE group. Initial evaluation of a novel prototype forward-viewing US endoscope in transmural drainage of pancreatic pseudocysts (with videos). Gastrointest Endosc. 66:1013–1017. 2007.PubMed/NCBI View Article : Google Scholar

24 

Chen PH, Tung CF, Peng YC, Yeh HZ, Chang CS and Chen CC: Duodenal major papilla morphology can affect biliary cannulation and complications during ERCP, an observational study. BMC Gastroenterol. 20(310)2020.PubMed/NCBI View Article : Google Scholar

25 

Perera KDR, Nawarathne NMM, Samarawickrama VT, Deraniyagala MP, Luxman WGE and Fernandopulle ANR: Endoscopic retrograde cholangiopancreatography in children: Feasibility, success, and safety with standard adult endoscopes and accessories. Pediatr Gastroenterol Hepatol Nutr. 25:406–412. 2022.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Koiava L, Koiava O, Abuladze D, Musiyarira L, Gavasheli S and Abiatari I: <p>Management of cholecysto‑choledocholithiasis by laparoendoscopic rendezvous: A single‑center series of 80 patients</p>. World Acad Sci J 8: 16, 2026.
APA
Koiava, L., Koiava, O., Abuladze, D., Musiyarira, L., Gavasheli, S., & Abiatari, I. (2026). <p>Management of cholecysto‑choledocholithiasis by laparoendoscopic rendezvous: A single‑center series of 80 patients</p>. World Academy of Sciences Journal, 8, 16. https://doi.org/10.3892/wasj.2026.431
MLA
Koiava, L., Koiava, O., Abuladze, D., Musiyarira, L., Gavasheli, S., Abiatari, I."<p>Management of cholecysto‑choledocholithiasis by laparoendoscopic rendezvous: A single‑center series of 80 patients</p>". World Academy of Sciences Journal 8.2 (2026): 16.
Chicago
Koiava, L., Koiava, O., Abuladze, D., Musiyarira, L., Gavasheli, S., Abiatari, I."<p>Management of cholecysto‑choledocholithiasis by laparoendoscopic rendezvous: A single‑center series of 80 patients</p>". World Academy of Sciences Journal 8, no. 2 (2026): 16. https://doi.org/10.3892/wasj.2026.431
Copy and paste a formatted citation
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Spandidos Publications style
Koiava L, Koiava O, Abuladze D, Musiyarira L, Gavasheli S and Abiatari I: <p>Management of cholecysto‑choledocholithiasis by laparoendoscopic rendezvous: A single‑center series of 80 patients</p>. World Acad Sci J 8: 16, 2026.
APA
Koiava, L., Koiava, O., Abuladze, D., Musiyarira, L., Gavasheli, S., & Abiatari, I. (2026). <p>Management of cholecysto‑choledocholithiasis by laparoendoscopic rendezvous: A single‑center series of 80 patients</p>. World Academy of Sciences Journal, 8, 16. https://doi.org/10.3892/wasj.2026.431
MLA
Koiava, L., Koiava, O., Abuladze, D., Musiyarira, L., Gavasheli, S., Abiatari, I."<p>Management of cholecysto‑choledocholithiasis by laparoendoscopic rendezvous: A single‑center series of 80 patients</p>". World Academy of Sciences Journal 8.2 (2026): 16.
Chicago
Koiava, L., Koiava, O., Abuladze, D., Musiyarira, L., Gavasheli, S., Abiatari, I."<p>Management of cholecysto‑choledocholithiasis by laparoendoscopic rendezvous: A single‑center series of 80 patients</p>". World Academy of Sciences Journal 8, no. 2 (2026): 16. https://doi.org/10.3892/wasj.2026.431
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