International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.
International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.
Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.
Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.
Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.
International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.
Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.
Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.
Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.
An International Open Access Journal Devoted to General Medicine.
Reversing DNA repair gene hypermethylation in breast cancer: The role of phytochemicals (Review)
Breast cancer (BC) is one of the most prevalent and lethal malignancies affecting women globally, and its progression is influenced by both genetic and epigenetic factors. Among the epigenetic modifications, the DNA hypermethylation of DNA repair genes has been linked to the progression of breast cancers. Notably, these epigenetic modifications can be reversed through natural dietary interventions. The present review discusses the role of natural phytochemicals, plant‑based compounds capable of reversing epigenetic modifications, which provide a promising alternative to conventional cancer therapies. Compounds such as genistein, curcumin, epigallocatechin gallate, sulforaphane, quercetin and apigenin have demonstrated the ability to reverse hypermethylated DNA repair genes, thereby restoring normal repair processes and improving cellular sensitivity to therapeutic agents. The present review emphasizes the importance of phytochemicals in causing epigenetic modifications and their potential as safer, more focused, affordable and low‑toxicity treatment options that could transform breast cancer management.