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Review Open Access

Bioactive compounds that enhance dopamine levels in the brain, with their challenges and future prospects (Review)

  • Authors:
    • Mohamed O. Elsamani
  • View Affiliations / Copyright

    Affiliations: Department of Chemistry, Al‑Baha University, Al‑Baha 65527, Kingdom of Saudi Arabia
    Copyright: © Elsamani et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 34
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    Published online on: March 9, 2026
       https://doi.org/10.3892/wasj.2026.449
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Abstract

The dopamine molecule serves as a neurotransmitter, functioning as an amine that is formed by removing a carboxyl group from L‑DOPA. This essential molecule (C8H11NO2) is produced by neurons to transmit information to other neurons in both the brain. The present review discusses the mechanisms through which the bioactive molecules such as naringenin, cyanidin, uridine, luteolin, rutin, caffeine and morphine can enhance dopamine synthesis, modulate its pathways and support brain health. Dopamine deficiency is a major risk factor for neurodegenerative disorders, and it is imperative to explore the relationship between dopamine level and neurodegenerative disorders. Bioactive molecules provide promising avenues for enhancing dopamine signaling and preventing neurodegenerative disorders; challenges remain in maximizing dopamine bioavailability using bioactive molecules. The present review highlights the various benefits of bioactive molecules in enhancing dopamine synthesis, preventing neurodegenerative disorders, and ensuring safety for brain health, as well as opportunities for future research.
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Spandidos Publications style
Elsamani MO: Bioactive compounds that enhance dopamine levels in the brain, with their challenges and future prospects (Review). World Acad Sci J 8: 34, 2026.
APA
Elsamani, M.O. (2026). Bioactive compounds that enhance dopamine levels in the brain, with their challenges and future prospects (Review). World Academy of Sciences Journal, 8, 34. https://doi.org/10.3892/wasj.2026.449
MLA
Elsamani, M. O."Bioactive compounds that enhance dopamine levels in the brain, with their challenges and future prospects (Review)". World Academy of Sciences Journal 8.3 (2026): 34.
Chicago
Elsamani, M. O."Bioactive compounds that enhance dopamine levels in the brain, with their challenges and future prospects (Review)". World Academy of Sciences Journal 8, no. 3 (2026): 34. https://doi.org/10.3892/wasj.2026.449
Copy and paste a formatted citation
x
Spandidos Publications style
Elsamani MO: Bioactive compounds that enhance dopamine levels in the brain, with their challenges and future prospects (Review). World Acad Sci J 8: 34, 2026.
APA
Elsamani, M.O. (2026). Bioactive compounds that enhance dopamine levels in the brain, with their challenges and future prospects (Review). World Academy of Sciences Journal, 8, 34. https://doi.org/10.3892/wasj.2026.449
MLA
Elsamani, M. O."Bioactive compounds that enhance dopamine levels in the brain, with their challenges and future prospects (Review)". World Academy of Sciences Journal 8.3 (2026): 34.
Chicago
Elsamani, M. O."Bioactive compounds that enhance dopamine levels in the brain, with their challenges and future prospects (Review)". World Academy of Sciences Journal 8, no. 3 (2026): 34. https://doi.org/10.3892/wasj.2026.449
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