Open Access

Interaction between diet and gastrointestinal endocrine cells (Review)

  • Authors:
    • Magdy El‑Salhy
    • Tarek Mazzawi
    • Trygve Hausken
    • Jan Gunnar Hatlebakk
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  • Published online on: April 12, 2016     https://doi.org/10.3892/br.2016.649
  • Pages: 651-656
  • Copyright: © El‑Salhy et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The gastrointestinal endocrine cells are essential for life. They regulate the gastrointestinal motility, secretion, visceral sensitivity, absorption, local immune defense, cell proliferation and appetite. These cells act as sensory cells with specialized microvilli that project into the lumen that sense the gut contents (mostly nutrients and/or bacteria byproducts), and respond to luminal stimuli by releasing hormones into the lamina propria. These released hormones exert their actions by entering the circulating blood and reaching distant targets (endocrine mode), nearby structures (paracrine mode) or via afferent and efferent synaptic transmission. The mature intestinal endocrine cells are capable of expressing several hormones. A change in diet not only affects the release of gastrointestinal hormones, but also alters the densities of the gut endocrine cells. The interaction between ingested foodstuffs and the gastrointestinal endocrine cells can be utilized for the clinical management of gastrointestinal and metabolic diseases, such as irritable bowel syndrome, obesity and diabetes.
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June-2016
Volume 4 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
El‑Salhy M, Mazzawi T, Hausken T and Hatlebakk JG: Interaction between diet and gastrointestinal endocrine cells (Review). Biomed Rep 4: 651-656, 2016
APA
El‑Salhy, M., Mazzawi, T., Hausken, T., & Hatlebakk, J.G. (2016). Interaction between diet and gastrointestinal endocrine cells (Review). Biomedical Reports, 4, 651-656. https://doi.org/10.3892/br.2016.649
MLA
El‑Salhy, M., Mazzawi, T., Hausken, T., Hatlebakk, J. G."Interaction between diet and gastrointestinal endocrine cells (Review)". Biomedical Reports 4.6 (2016): 651-656.
Chicago
El‑Salhy, M., Mazzawi, T., Hausken, T., Hatlebakk, J. G."Interaction between diet and gastrointestinal endocrine cells (Review)". Biomedical Reports 4, no. 6 (2016): 651-656. https://doi.org/10.3892/br.2016.649