Gene mutations in Cushing's disease (Review)

  • Authors:
    • Qi Xiong
    • Wei Ge
  • View Affiliations

  • Published online on: July 29, 2016     https://doi.org/10.3892/br.2016.729
  • Pages: 277-282
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Abstract

Cushing's disease (CD) is a severe (and potentially fatal) disease caused by adrenocorticotropic hormone (ACTH)-secreting adenomas of the pituitary gland (often termed pituitary adenomas). The majority of ACTH‑secreting corticotroph tumors are sporadic and CD rarely appears as a familial disorder, thus, the genetic mechanisms underlying CD are poorly understood. Studies have reported that various mutated genes are associated with CD, such as those in menin 1, aryl hydrocarbon receptor‑interacting protein and the nuclear receptor subfamily 3 group C member 1. Recently it was identified that ubiquitin‑specific protease 8 mutations contribute to CD, which was significant towards elucidating the genetic mechanisms of CD. The present study reviews the associated gene mutations in CD patients.
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September-2016
Volume 5 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Xiong Q and Xiong Q: Gene mutations in Cushing's disease (Review). Biomed Rep 5: 277-282, 2016
APA
Xiong, Q., & Xiong, Q. (2016). Gene mutations in Cushing's disease (Review). Biomedical Reports, 5, 277-282. https://doi.org/10.3892/br.2016.729
MLA
Xiong, Q., Ge, W."Gene mutations in Cushing's disease (Review)". Biomedical Reports 5.3 (2016): 277-282.
Chicago
Xiong, Q., Ge, W."Gene mutations in Cushing's disease (Review)". Biomedical Reports 5, no. 3 (2016): 277-282. https://doi.org/10.3892/br.2016.729