Treatment of condyloma acuminata in pregnant women with cryotherapy combined with proanthocyanidins: Outcome and safety

Yang,Li‑Juan; Zhu,Dong‑Ning; Dang,Yan‑Ling; Zhao,Xiong

doi:10.3892/etm.2016.3207

Treatment of condyloma acuminata in pregnant women with cryotherapy combined with proanthocyanidins: Outcome and safety

Authors:
- Li‑Juan Yang
- Dong‑Ning Zhu
- Yan‑Ling Dang
- Xiong Zhao
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Affiliations: Department of Dermatology, Maternal and Child Health Hospital of Shaanxi, Xi'an, Shaanxi 710003, P.R. China, Department of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China
Published online on: March 30, 2016 https://doi.org/10.3892/etm.2016.3207
Pages: 2391-2394

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Abstract

Patients with condyloma acuminata (CA) during pregnancy represent a special risk group. The outcomes of many treatment methods for such cases are not satisfactory. The purpose of the present study was to evaluate the treatment outcome and safety of cryotherapy combined with proanthocyanidins (PCs) for CA in pregnant women. In this study, 46 pregnant women with CA were treated with cryotherapy combined with PCs. The lesions were sprayed with liquid nitrogen until the color of the wart changed from flesh colored to purple. A PC‑containing formulation was then sprayed onto a non‑woven fabric or single‑layer gauze and applied to the affected area. The PC treatment was applied for 20 min, 2 or 3 times per day. All patients were followed up at 1 and 3 months. No visible warts remained after the cryotherapy and PC treatment. At the 1‑month follow‑up, only 1 case of recurrence was identified. At 3 months, 5 cases of recurrence were identified, and the recurrence rate was 10.9%. The satisfaction rate of the patients was 94% at 1 month and 87% at 3 months after treatment. All pregnancies resulted in healthy live births without delivery complications. Cryotherapy combined with PCs is indicated to be a safe and effective procedure and may serve as a treatment option for pregnant women with CA.

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