Status epilepticus: Using antioxidant agents as alternative therapies (Review)

Carmona‑Aparicio,Liliana; Zavala‑Tecuapetla,Cecilia; González‑Trujano,María   Eva; Sampieri,Aristides Iii; Montesinos‑Correa,Hortencia; Granados‑Rojas,Leticia; Floriano‑Sánchez,Esaú; Coballase‑Urrutía,Elvia; Cárdenas‑Rodríguez,Noemí

doi:10.3892/etm.2016.3609

Status epilepticus: Using antioxidant agents as alternative therapies (Review)

Authors:
- Liliana Carmona‑Aparicio
- Cecilia Zavala‑Tecuapetla
- María Eva González‑Trujano
- Aristides Iii Sampieri
- Hortencia Montesinos‑Correa
- Leticia Granados‑Rojas
- Esaú Floriano‑Sánchez
- Elvia Coballase‑Urrutía
- Noemí Cárdenas‑Rodríguez
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Affiliations: Laboratory of Neurosciences, National Institute of Pediatrics, Mexico City 04530, Mexico, Laboratory of Physiology of The Reticular Formation Reticular, National Institute of Neurology and Neurosurgery, Mexico City 14269, Mexico, Laboratory of Neuropharmacology of Natural Products, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico, Department of Comparative Biology, Faculty of Sciences, National Autonomous University of Mexico, Mexico City 04150, Mexico, Services of Endocrinology, National Institute of Pediatrics, Mexico City 04530, Mexico, Military School of Graduate of Health, Multidisciplinary Research Laboratory, Secretariat of National Defense, Mexico City 11270, Mexico
Published online on: August 23, 2016 https://doi.org/10.3892/etm.2016.3609
Pages: 1957-1962

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Abstract

The epileptic state, or status epilepticus (SE), is the most serious situation manifested by individuals with epilepsy, and SE events can lead to neuronal damage. An understanding of the molecular, biochemical and physiopathological mechanisms involved in this type of neurological disease will enable the identification of specific central targets, through which novel agents may act and be useful as SE therapies. Currently, studies have focused on the association between oxidative stress and SE, the most severe epileptic condition. A number of these studies have suggested the use of antioxidant compounds as alternative therapies or adjuvant treatments for the epileptic state.

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