Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report

  • Authors:
    • Chunkui Zhou
    • Lijun Zhu
    • Shaokuan Fang
  • View Affiliations

  • Published online on: August 12, 2016     https://doi.org/10.3892/etm.2016.3594
  • Pages: 2227-2229
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Herpes simplex virus (HSV) is the most common cause of acute viral encephalitis. Acute retinal necrosis (ARN) is a rapidly progressing and potentially blinding eye disease that may be induced by HSV. The present case study reports the very rare case of a patient with herpes simplex encephalitis (HSE) combined with acute retinal necrosis (ARN). A 47‑year‑old woman was admitted to hospital with persistent high fever and somnolence for 5 days. Magnetic resonance imaging showed abnormal signals in the right medial temporal lobes, and HSV-1 was identified in the serum and cerebrospinal fluid. Five days later, despite treatment with intravenous acyclovir and partial improvement in consciousness, the patient suddenly developed blurred vision and bilateral visual pain. Fundus fluorescence angiography revealed bilateral vessel obstruction and flaky reduced fluorescence. ARN was diagnosed clinically. Dexamethasone was administered as an anti-inflammatory adjunct to intravenous acyclovir therapy. The visual acuity of the patient was reduced to mere light perception a further 4 days later. The present case indicates that HSE may be complicated with ARN, causing a reduction in visual acuity to mere light perception within a very short time.

Introduction

Herpes simplex encephalitis (HSE) is associated with high mortality and morbidity rates (1). Relapses and new infections at anatomically different sites, including the eye, may occur due to reactivation and neuronal translocation of the causative agent, herpes simplex virus (HSV) (2). HSE may be a risk factor for the development of acute retinal necrosis (ARN), a rapidly progressing and potentially blinding eye disease induced by HSV (2). ARN was initially described as a rapidly progressive unilateral necrotizing retinitis in 1971 by Urayama et al (3). The prevalence of the disease is equal in both sexes and it typically occurs between the fifth and seventh decades of life (4). To prevent a poor outcome, ARN requires aggressive management (5). Although several case reports have described the occurrence of ARN after herpetic encephalitis (6), ARN following HSE is rare (7). In the present case report, the case of a healthy woman with bilateral ARN that occurred in combination with HSE following treatment with intravenous acyclovir is described.

Case report

A 47-year-old woman was admitted to the First Teaching Hospital of Jilin University (Changchun, China) in October 2013 with persistent high fever and somnolence for 5 days. Magnetic resonance imaging (MRI) showed abnormal signals in the right medial temporal lobes (Fig. 1). The history of the patient included frequent oral herpes lesions and infection of the upper respiratory tract. Therefore, viral encephalitis was suspected and treatment with intravenous acyclovir (10 mg/kg) was initiated and continued every 8 h. HSV-1 was identified in the patient's serum and cerebrospinal fluid by polymerase chain reaction (PCR), which was performed in our clinical laboratory. Examination of the cerebrospinal fluid also showed that the patient's glucose levels remained at a normal level (2.7 mmol/l; normal range, 2.5–4.4 mmol/l), while the monocyte count was elevated (2.7×107/l; normal range, 0–5×106/l). An electroencephalogram revealed intermittent rhythmic slowing in the bilateral hemispheres.

Five days after admission, the patient's consciousness was slightly improved, but she suddenly developed blurred vision and visual pain bilaterally. Dexamethasone (15 mg/day; Jilin Aodong Pharmaceutical Group Co., Ltd., Jilin, China) was administered intravenously for 15 days as an anti-inflammatory adjunct to intravenous acyclovir therapy. A further 4 days later, only light perception remained in both eyes. Examination of the left eye revealed extensive vitritis and retinal thickening with advanced retinal necrosis in the peripheral and central retina. The optic disc was swollen along with an inferior retinal detachment, extending to the macula. Extensive retinal vasculitis and hemorrhage were observed. Ultrasound examination showed a thickened temporal wall in the right eye (Fig. 2). Fundus fluorescence angiography (FFA) was conducted in the hospital ophthalmology department, and revealed bilateral vessel obstruction and a large amount of low fluorescence, with a flaky appearance, in the background (Fig. 3). HSE complicated with ARN was considered clinically, marked by weak light perception. HSV-1 was also detected through vitreous tap with PCR analysis and this confirmed the diagnosis. Following diagnosis, the patient was treated with intravenously administered acyclovir and dexamethasone, and mere light perception remained in each eye.

Informed consent was obtained from the patient for the publication of the present case study.

Discussion

The characteristics of ARN syndrome are anterior segment inflammation, along with periorbital pain, and a loss of vision due to vitreous opacification, necrotizing retinitis and, occasionally, optic neuropathy (8). In the past, ARN was only diagnosed clinically. However, as understanding of the pathophysiology of ARN advanced, adjunct laboratory tests were developed. According to the standard clinical criteria of the American Uveitis Society (9), the diagnosis of ARN can be made on the basis of focal, well-demarcated areas of retinal necrosis within the peripheral retina; rapid, circumferential progression of necrosis; and occlusive vasculopathy. PCR is a valuable diagnostic tool for the diagnosis of ARN (10). The patient described in the present case study manifested a classic case of fulminant bilateral ARN. In contrast to recovery from impaired light perception in reported cases of ARN syndrome (11,12), the present patient responded poorly to antiviral and steroidal treatments. The poor visual outcome of this patient may be associated with impairment of the optic nerve in addition to extensive retinal detachment and her possible poor immune status.

HSV is the most common cause of acute viral encephalitis (13). The majority of infections in adults involve HSV-1, and few cases are attributed to HSV-2 (14). HSE typically affects the fronto-temporal lobe (1). The results of MRI and electroencephalography support the diagnosis of HSE in the present patient. The diagnosis of HSE complicated with ARN was supported by clinical findings and analysis of the cerebrospinal fluid and vitreous tap using PCR. The patient's cerebrospinal fluid and vitreous tap tested positive for HSV-1. Furthermore, the patient had a history of oral lesions. Although the majority of cases of HSV-related retinitis are established clinically, the patient's cerebrospinal fluid and vitreous tap tested positive for HSV-1. Several reports have described a retinitis that is consistent with ARN syndrome (6,7,15). However, to the best of our knowledge there have not been any previous reports of fulminant HSE with ARN syndrome in which the visual ability was reduced to mere light perception within 4 days.

The potential of HSV to latently infect neurons within the central nervous system is well established. HSV is reactivated and spread via intra-axonal, trans-synaptic and extracellular mechanisms, resulting in damaging effects on remote and local tissue. The ability of HSV to migrate has been demonstrated in an animal model, where recombinant HSV was injected into the anterior chamber of one eye and retinitis subsequently occurred in the other eye, due to viral migration along the hypothalamus and contralateral optic nerve. It was hypothesized that the virus may have migrated from the suprachiasmatic nucleus to the retina by retrograde axonal transport along the optic nerve (16). Vandercam et al (17) described a case with an overall interval of 5 weeks (from 14 days to 2 months) between encephalitis and ARN. In the present patient, encephalitis occurred ~1 week prior to the symptoms of retinal disease. It is hypothesized that activated virus in the medial temporal lobes may have been transported to the retina axonally via the optic nerve, resulting in ARN.

Acknowledgements

The authors thank Dr. He for his excellent assistance in ophthalmology in the present study.

References

1 

Whitley RJ: Herpes simplex virus infections of the central nervous system: A review. Am J Med. 85:61–67. 1988.PubMed/NCBI

2 

Ganatra JB, Chandler D, Santos C, Kuppermann B and Margolis TP: Viral causes of the acute retinal necrosis syndrome. Am J Ophthalmol. 129:166–172. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Urayama A, Yamad N, Sasaki T, et al: Unilateral acute uveitis with retinal periretinal arteritis and detachment. Jpn J clin Ophthalmol. 25:607–619. 1971.

4 

Bodaghi B, Rozenberg F, Cassoux N, Fardeau C and LeHoang P: Nonnecrotizing herpetic retinopathies masquerading as severe posterior uveitis. Ophthalmology. 110:1737–1743. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Palay DA, Sternberg P Jr, Davis J, Lewis H, Holland GN, Mieler WF, Jabs DA and Drews C: Decrease in the risk of bilateral acute retinal necrosis by acyclovir therapy. Am J Ophthalmol. 112:250–255. 1991. View Article : Google Scholar : PubMed/NCBI

6 

Gain P, Chiquet C, Thuret G, Drouet E and Antoine JC: Herpes simplex virus type 1 encephalitis associated with acute retinal necrosis syndrome in an immunocompetent patient. Acta Ophthalmol Scand. 80:546–549. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Tada Y, Negoro K, Morimatsu M, Makino H and Nishida T: Findings in a patient with herpes simplex viral meningitis associated with acute retinal necrosis syndrome. AJNR Am J Neuroradiol. 22:1300–1302. 2001.PubMed/NCBI

8 

Sergott RC, Belmont JB, Savino PJ, Fischer DH, Bosley TM and Schatz NJ: Optic nerve involvement in the acute retinal necrosis syndrome. Arch Ophthalmol. 103:1160–1162. 1985. View Article : Google Scholar : PubMed/NCBI

9 

Holland GN: Executive Committee of the American Uveitis Society: Standard diagnostic criteria for the acute retinal necrosis syndrome. Am J Ophthalmol. 117:663–667. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Tran TH, Rozenberg F, Cassoux N, Rao NA, LeHoang P and Bodaghi B: Polymerase chain reaction analysis of aqueous humour samples in necrotizing retinitis. Br J Ophthalmol. 87:79–83. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Kianersi F, Masjedi A and Ghanbari H: Acute retinal necrosis after herpetic encephalitis. Case Rep Ophthalmol. 1:85–89. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Hirota K, Akimoto M and Katsura T: Bilateral acute retinal necrosis after herpetic meningitis. Clin Ophthalmol. 6:551–553. 2012.PubMed/NCBI

13 

Burk J and Miller JR: Infections of the nervous systemMerritt's Textbook of Neurology. Rowland LP: Williams and Wilkins; Baltimore, MD: pp. 1546–159. 1995

14 

Whitley RJ: Herpes simples virusFields Virology. Fields BN, Knipe DM and Howley PM: 3rd. Lippincott-Raven Publishers; Philadelphia: pp. 2323–2330. 1996

15 

Pepose JS, Kreiger AE, Tomiyasu U, Cancilla PA and Foos RY: Immunocytologic localization of herpes simplex type 1 viral antigens in herpetic retinitis and encephalitis in an adult. Ophthalmology. 92:160–166. 1985. View Article : Google Scholar : PubMed/NCBI

16 

Vann VR and Atherton SS: Neural spread of herpes simplex virus after anterior chamber inoculation. Invest Ophthalmol Vis Sci. 32:2462–2472. 1991.PubMed/NCBI

17 

Vandercam T, Hintzen RQ, de Boer JH and Van der Lelij A: Herpetic encephalitis is a risk factor for acute retinal necrosis. Neurology. 71:1268–1274. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

Journal Cover

October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhou C, Zhu L and Fang S: Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report. Exp Ther Med 12: 2227-2229, 2016
APA
Zhou, C., Zhu, L., & Fang, S. (2016). Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report. Experimental and Therapeutic Medicine, 12, 2227-2229. https://doi.org/10.3892/etm.2016.3594
MLA
Zhou, C., Zhu, L., Fang, S."Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report". Experimental and Therapeutic Medicine 12.4 (2016): 2227-2229.
Chicago
Zhou, C., Zhu, L., Fang, S."Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2227-2229. https://doi.org/10.3892/etm.2016.3594