Evaluation of the effects of ketamine on spinal anesthesia with levobupivacaine or ropivacaine

  • Authors:
    • Yan Zhang
    • Hong Lin
    • Wen‑Bo Yi
  • View Affiliations

  • Published online on: August 10, 2016     https://doi.org/10.3892/etm.2016.3587
  • Pages: 2290-2296
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Spinal anesthesia or regional anesthesia is a potent anesthetic procedure. Additional modalities have been sought to increase the duration of block in spinal anesthesia. Ketamine is an N‑methyl‑D‑aspartate (NMDA) receptor blocker that has an anesthetic effect when injected intrathecally and has a synergic effect with bupivacaine. Ketamine also has potent analgesic properties. The present study investigated the effect of intrathecally administered ketamine on spinal anesthesia with levobupivacaine or ropivacaine. Sprague‑Dawley rats at post‑natal day 21 were exposed to spinal anesthesia with 0.5% levobupivacaine or 0.5% ropivacaine. Separate groups of rats were treated with intrathecal ketamine at a 5 or 10 mg/kg bodyweight dose along with ropivacaine or levobupivacaine. The thermal and mechanical withdrawal latencies of the animals were determined using hot plate and von Frey filaments, respectively. A rotarod apparatus was employed to assess the capacity of the rats to rotate the spindle at 24 h following anesthesia. The gait of the rat pups was also assessed. Intrathecal administration of ketamine resulted in dense blocks and extended the duration of spinal blocks as evidenced by thermal latencies and responses to von Frey filaments. The latency to fall was shorter in rats exposed to ketamine along with ropivacaine or levobupivacaine spinal anesthesia. The gait parameters were also more disturbed upon ketamine administration. In conclusion, ketamine administration with ropivacaine or levobupivacaine increased the intensity and duration of spinal blockade, thereby increasing the anesthetic effects.
View Figures
View References

Related Articles

Journal Cover

October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Lin H and Yi WB: Evaluation of the effects of ketamine on spinal anesthesia with levobupivacaine or ropivacaine. Exp Ther Med 12: 2290-2296, 2016
APA
Zhang, Y., Lin, H., & Yi, W. (2016). Evaluation of the effects of ketamine on spinal anesthesia with levobupivacaine or ropivacaine. Experimental and Therapeutic Medicine, 12, 2290-2296. https://doi.org/10.3892/etm.2016.3587
MLA
Zhang, Y., Lin, H., Yi, W."Evaluation of the effects of ketamine on spinal anesthesia with levobupivacaine or ropivacaine". Experimental and Therapeutic Medicine 12.4 (2016): 2290-2296.
Chicago
Zhang, Y., Lin, H., Yi, W."Evaluation of the effects of ketamine on spinal anesthesia with levobupivacaine or ropivacaine". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2290-2296. https://doi.org/10.3892/etm.2016.3587