Open Access

Raman spectrum: A potential biomarker for embryo assessment during in vitro fertilization

  • Authors:
    • Jiayi Ding
    • Tian Xu
    • Xiaofang Tan
    • Hua Jin
    • Jun Shao
    • Haibo Li
  • View Affiliations

  • Published online on: February 23, 2017     https://doi.org/10.3892/etm.2017.4160
  • Pages: 1789-1792
  • Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the study was to investigate whether Raman spectrum is consistent with the morphological scoring of the embryo of day 3 during in vitro fertilization (IVF). The spent culture media of embryo of day 3 from 10 patients were collected and analyzed. The samples were analyzed using Raman spectroscopy and graded according to the standard embryo scoring system simultaneously. Data showed that the Raman spectra obtained from the droplet of media were useful, as they can act as the characteristic signature for protein and amino acids. The Raman biospectroscopy-based metabonomics profiling of spent media was consistent with the result of conventional morphological evaluation. In conclusion, this technology offers great potential for the development of tools allowing rapid non-invasive assessment of the quality of embryo of day 3 during IVF.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ding J, Xu T, Tan X, Jin H, Shao J and Li H: Raman spectrum: A potential biomarker for embryo assessment during in vitro fertilization. Exp Ther Med 13: 1789-1792, 2017
APA
Ding, J., Xu, T., Tan, X., Jin, H., Shao, J., & Li, H. (2017). Raman spectrum: A potential biomarker for embryo assessment during in vitro fertilization. Experimental and Therapeutic Medicine, 13, 1789-1792. https://doi.org/10.3892/etm.2017.4160
MLA
Ding, J., Xu, T., Tan, X., Jin, H., Shao, J., Li, H."Raman spectrum: A potential biomarker for embryo assessment during in vitro fertilization". Experimental and Therapeutic Medicine 13.5 (2017): 1789-1792.
Chicago
Ding, J., Xu, T., Tan, X., Jin, H., Shao, J., Li, H."Raman spectrum: A potential biomarker for embryo assessment during in vitro fertilization". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1789-1792. https://doi.org/10.3892/etm.2017.4160