Protective effect of a novel antifungal peptide derived from human chromogranin a on the immunity of mice infected with Candida krusei

  • Authors:
    • Ruifang Li
    • Lin Zhang
    • Huiru Zhang
    • Yanjie Yi
    • Le Wang
    • Liang Chen
    • Lan Zhang
  • View Affiliations

  • Published online on: March 30, 2017     https://doi.org/10.3892/etm.2017.4290
  • Pages: 2429-2434
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Abstract

Invasive fungal infections threat the life of immunocompromised patients. Chromogranin A N‑46 (CGA-N46), corresponding to the 31st to 76th amino acids of the N‑terminus of human chromogranin A, is an antifungal peptide. In order to elucidate the antifungal effects of CGA‑N46 in vivo, we studied its effects on cell‑mediated immunity in Candida krusei‑infected mice. The results showed that the treatment with CGA‑N46 increased the average body weight and decreased the mortality of the immunocompromised mice model infected with Candida krusei. The spleen and thymus indices of treated mice has markedly increased compared with that of the control group (P<0.05), and the immune cell levels in peripheral blood also increased significantly (P<0.05). The immuno‑modulatory effect of CGA‑N46 (60 mg/kg/day) was found to be comparable to that of terbinafine. Additionally, CGA‑N46 could alleviate or eliminate histopathological symptoms in the liver, spleen, kidney, and lung tissues. In conclusion, the present study suggests that CGA‑N46 may offer a new strategy for antifungal therapeutic option. This study is an essential step in elucidating the effect of CGA‑N46 in vivo.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li R, Zhang L, Zhang H, Yi Y, Wang L, Chen L and Zhang L: Protective effect of a novel antifungal peptide derived from human chromogranin a on the immunity of mice infected with Candida krusei. Exp Ther Med 13: 2429-2434, 2017
APA
Li, R., Zhang, L., Zhang, H., Yi, Y., Wang, L., Chen, L., & Zhang, L. (2017). Protective effect of a novel antifungal peptide derived from human chromogranin a on the immunity of mice infected with Candida krusei. Experimental and Therapeutic Medicine, 13, 2429-2434. https://doi.org/10.3892/etm.2017.4290
MLA
Li, R., Zhang, L., Zhang, H., Yi, Y., Wang, L., Chen, L., Zhang, L."Protective effect of a novel antifungal peptide derived from human chromogranin a on the immunity of mice infected with Candida krusei". Experimental and Therapeutic Medicine 13.5 (2017): 2429-2434.
Chicago
Li, R., Zhang, L., Zhang, H., Yi, Y., Wang, L., Chen, L., Zhang, L."Protective effect of a novel antifungal peptide derived from human chromogranin a on the immunity of mice infected with Candida krusei". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2429-2434. https://doi.org/10.3892/etm.2017.4290